4Q0A

Vitamin D Receptor complex with lithocholic acid

Summary for 4Q0A

Related2HC4 2HCD
DescriptorVitamin D3 receptor A, Nuclear receptor coactivator 2, (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, ... (4 entities in total)
Functional Keywordsalpha-helical sandwich, transcription factor, calcitriol binding, dna binding, nucleus, gene regulation
Biological sourceDanio rerio (leopard danio,zebra danio,zebra fish)
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Cellular locationNucleus Q9PTN2 Q15596
Total number of polymer chains2
Total molecular weight36032.31
Authors
Belorusova, A.,Rochel, N. (deposition date: 2014-04-01, release date: 2014-07-02)
Primary citation
Belorusova, A.Y.,Eberhardt, J.,Potier, N.,Stote, R.H.,Dejaegere, A.,Rochel, N.
Structural insights into the molecular mechanism of vitamin d receptor activation by lithocholic Acid involving a new mode of ligand recognition.
J.Med.Chem., 57:4710-4719, 2014
PubMed: 24818857 (PDB entries with the same primary citation)
DOI: 10.1021/jm5002524
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.251801.8%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4q0a
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Molmil generated image of 4q0a
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Molmil generated image of 4q0a
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More Biological unit images

Molmil generated image of 4q0a
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Molmil generated image of 4q0a
rotated about x axis by 90°
Molmil generated image of 4q0a
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4q0a.pdb1.gz [44.04 KB])
Coordinate files for Biological unit (4q0a.pdb2.gz [86.45 KB])