4Q0A

Vitamin D Receptor complex with lithocholic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4OA C 501

Chain	Residue
C	TYR175
C	HOH634
C	HOH641
C	LEU261
C	VAL262
C	SER303
C	SER306
C	TRP314
C	LEU338
C	HOH602
C	HOH628

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 4OA C 502

Chain	Residue
C	ASP181
C	ARG184
C	PHE185
C	ARG186
C	SER263
C	GLN267
C	MET438
C	GLN439
C	HOH613
C	HOH637
C	HOH668
C	HOH672

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"UniProtKB","id":"P13053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"UniProtKB","id":"P11473","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17218092","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HC4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

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