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2KUO
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BU of 2kuo by Molmil
Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response
Descriptor: Aprataxin and PNK-like factor, ZINC ION
Authors:Li, G.Y, McCulloch, R.D, Fenton, A, Cheung, M, Meng, L, Ikura, M, Koch, C.A.
Deposit date:2010-02-23
Release date:2010-05-05
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure and identification of ADP-ribose recognition motifs of aprataxin PNK-like factor (APLF) required for the interaction with sites of DNA damage response
To be Published
2KUU
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BU of 2kuu by Molmil
Solution Structure of K10 TLS RNA (GC mutant in upper helix)
Descriptor: K10 TLS RNA
Authors:Bullock, S.L, Ringel, I, Ish-Horowicz, D, Lukavsky, P.J.
Deposit date:2010-03-01
Release date:2010-05-19
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A'-form RNA helices are required for cytoplasmic mRNA transport in Drosophila.
Nat.Struct.Mol.Biol., 17, 2010
2PU2
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BU of 2pu2 by Molmil
AmpC beta-lactamase with bound Phthalamide inhibitor
Descriptor: 2-[(1R)-1-CARBOXY-2-(4-HYDROXYPHENYL)ETHYL]-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2007-05-08
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
J.Med.Chem., 51, 2008
2HPT
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BU of 2hpt by Molmil
Crystal Structure of E. coli PepN (Aminopeptidase N)in complex with Bestatin
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Aminopeptidase N, GLYCEROL, ...
Authors:Addlagatta, A, Matthews, B.W, Gay, L.
Deposit date:2006-07-17
Release date:2006-08-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2P23
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BU of 2p23 by Molmil
Crystal structure of human FGF19
Descriptor: Fibroblast growth factor 19
Authors:Mohammadi, M.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
4NH4
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BU of 4nh4 by Molmil
Structure of the binary complex of a zingiber officinale double bond reductase in complex with NADP
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Zingiber officinale double bond reductase
Authors:Langlois D'Estaintot, B, Buratto, J, Granier, T, Gallois, B, Willis, M.A, Sang, Y, Flores-Sanchez, I.J, Gang, D.R.
Deposit date:2013-11-04
Release date:2014-11-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of zingiber officinale double bond reductase
To be Published
1QAW
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BU of 1qaw by Molmil
Regulatory Features of the TRP Operon and the Crystal Structure of the TRP RNA-Binding Attenuation Protein from Bacillus Stearothermophilus.
Descriptor: TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN
Authors:Chen, X.-P, Antson, A.A, Yang, M, Baumann, C, Dodson, E.J, Dodson, G.G, Gollnick, P.
Deposit date:1999-03-31
Release date:1999-04-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulatory features of the trp operon and the crystal structure of the trp RNA-binding attenuation protein from Bacillus stearothermophilus.
J.Mol.Biol., 289, 1999
2H3L
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BU of 2h3l by Molmil
Crystal Structure of ERBIN PDZ
Descriptor: LAP2 protein
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
4MKA
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BU of 4mka by Molmil
Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 13 (N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide)
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1-oxo-1H-isochromen-7-yl}methanesulfonamide, ...
Authors:Harris, S.F, Wong, A.
Deposit date:2013-09-04
Release date:2013-10-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B.
J.Med.Chem., 56, 2013
2KNZ
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BU of 2knz by Molmil
NMR structure of CIP75 UBA domain
Descriptor: Ubiquilin-4
Authors:Kieken, F, Spagnol, G, Su, V, Lau, A.F, Sorgen, P.L.
Deposit date:2009-09-08
Release date:2010-03-16
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR structure note: UBA domain of CIP75.
J.Biomol.Nmr, 46, 2010
2KQE
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BU of 2kqe by Molmil
Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine
Descriptor: ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ...
Authors:Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
Deposit date:2009-11-04
Release date:2010-01-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
3OKI
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BU of 3oki by Molmil
Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide
Descriptor: (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-25
Release date:2010-12-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
Bioorg.Med.Chem.Lett., 21, 2010
3OMM
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BU of 3omm by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-27
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
1XAC
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BU of 1xac by Molmil
CHIMERA ISOPROPYLMALATE DEHYDROGENASE BETWEEN BACILLUS SUBTILIS (M) AND THERMUS THERMOPHILUS (T) FROM N-TERMINAL: 20% T MIDDLE 20% M RESIDUAL 60% T, MUTATED AT S82R. LOW TEMPERATURE (100K) STRUCTURE.
Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE 2T2M6T S82R
Authors:Nagata, C, Moriyama, H, Tanaka, N.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme.
Acta Crystallogr.,Sect.D, 52, 1996
1XAD
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BU of 1xad by Molmil
CHIMERA ISOPROPYLMALATE DEHYDROGENASE BETWEEN BACILLUS SUBTILIS (M) AND THERMUS THERMOPHILUS (T) FROM N-TERMINAL: 20% T MIDDLE 20% M RESIDUAL 60% T, MUTATED AT S82R. LOW TEMPERATURE (150K) STRUCTURE.
Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE 2T2M6T S82R
Authors:Nagata, C, Moriyama, H, Tanaka, N.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme.
Acta Crystallogr.,Sect.D, 52, 1996
3OOK
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BU of 3ook by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-31
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
2KYK
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BU of 2kyk by Molmil
The sandwich region between two LMP2A PY motif regulates the interaction between AIP4WW2domain and PY motif
Descriptor: E3 ubiquitin-protein ligase Itchy homolog
Authors:Seo, M, Park, S, Seok, S, Kim, J, Cha, M, Lee, B.
Deposit date:2010-05-28
Release date:2011-06-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:The sandwich region between two LMP2A PY motif regulates the interaction between AIP4WW2domain and PY motif
To be Published
2KUW
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BU of 2kuw by Molmil
Solution Structure of K10 TLS RNA (A-form mutant in lower helix)
Descriptor: K10 TLS RNA
Authors:Bullock, S.L, Ringel, I, Ish-Horowicz, D, Lukavsky, P.J.
Deposit date:2010-03-01
Release date:2010-05-19
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A'-form RNA helices are required for cytoplasmic mRNA transport in Drosophila.
Nat.Struct.Mol.Biol., 17, 2010
2KY6
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BU of 2ky6 by Molmil
Structure of ARC92VBD/MED25ACID
Descriptor: Mediator of RNA polymerase II transcription subunit 25
Authors:Milbradt, A.G, Sun, Z.J, Selenko, P, Takeuchi, K, Naar, A.M, Wagner, G.
Deposit date:2010-05-14
Release date:2011-03-09
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure of the VP16 transactivator target in the Mediator.
Nat.Struct.Mol.Biol., 18, 2011
3OKH
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BU of 3okh by Molmil
Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid
Descriptor: 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-25
Release date:2010-12-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
Bioorg.Med.Chem.Lett., 21, 2010
3OMK
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BU of 3omk by Molmil
Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide
Descriptor: (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-27
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
3AL3
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BU of 3al3 by Molmil
Crystal Structure of TopBP1 BRCT7/8-BACH1 peptide complex
Descriptor: DNA topoisomerase 2-binding protein 1, FORMIC ACID, Peptide of Fanconi anemia group J protein
Authors:Leung, C.C, Glover, J.N.
Deposit date:2010-07-22
Release date:2010-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control
J.Biol.Chem., 286, 2011
2H28
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BU of 2h28 by Molmil
Crystal structure of YeeU from E. coli. Northeast Structural Genomics target ER304
Descriptor: CHLORIDE ION, GLYCEROL, Hypothetical protein yeeU, ...
Authors:Arbing, M, Su, M, Benach, J, Karpowich, N.K, Jiang, M, Xiao, R, Cunningham, K, Ma, L.-C, Chen, C.X, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-05-18
Release date:2006-07-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems.
Structure, 18, 2010
2KR9
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BU of 2kr9 by Molmil
Kalirin DH1 NMR structure
Descriptor: Kalirin
Authors:Gorbatyuk, V.Y, Schiller, M.R, Hoch, J.C.
Deposit date:2009-12-10
Release date:2010-12-15
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:The solution NMR structure of the first Dbl domain of RhoGEF Kalirin.
To be Published
2KRK
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BU of 2krk by Molmil
Solution NMR Structure of 26S protease regulatory subunit 8 from H.sapiens, Northeast Structural Genomics Consortium Target Target HR3102A
Descriptor: 26S protease regulatory subunit 8
Authors:Liu, G, Janjua, J, Xiao, R, Ciccosanti, C, Shastry, R, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Solution NMR Structure of 26S protease regulatory subunit 8 from H.sapiens, Northeast Structural Genomics Consortium Target HR3102A
To be Published

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