PDB: 8717 resultsInfo pagesStatus searchChemie searchBIRD

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7LP7	The crystal structure of the wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000983476 Descriptor: (phenylmethyl) (2~{S})-2-[5-oxidanyl-6-oxidanylidene-4-(2-pyridin-4-ylethylcarbamoyl)-1~{H}-pyrimidin-2-yl]pyrrolidine-1-carboxylate, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. Deposit date: 2021-02-11 Release date: 2022-02-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of the wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000983476 To Be Published
3DOG	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1 Descriptor: (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol, Cell division protein kinase 2, Cyclin-A2, ... Authors: Echalier, A, Endicott, J. Deposit date: 2008-07-04 Release date: 2008-09-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.7 Å) Cite: N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine. Mol.Cancer Ther., 7, 2008
6EUV	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787) Descriptor: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2 Authors: Cusack, S, Lethier, M. Deposit date: 2017-10-31 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6IC9	Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser7 Descriptor: PHD finger protein 3, TYR-SEP-PRO-THR-SER-PRO-SEP-TYR-SEP-PRO-THR-SER-PRO Authors: Grishkovskaya, I, Djinovic-Carugo, K, Slade, D. Deposit date: 2018-12-03 Release date: 2020-07-15 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (1.748 Å) Cite: PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC Nat Commun, 12, 2021
7KNR	The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988558 Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Jayaraman, S, White, S.W. Deposit date: 2020-11-05 Release date: 2021-11-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988558 To Be Published
7KNY	The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988528 Descriptor: 2-(2-fluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Jayaraman, S, White, S.W. Deposit date: 2020-11-06 Release date: 2021-11-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988528 To Be Published
7KOP	The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with SJ000988539 Descriptor: 2-(2-fluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Seetharaman, J, White, S.W. Deposit date: 2020-11-09 Release date: 2021-11-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.33 Å) Cite: The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with SJ000988539 To Be Published
6HR2	Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB Descriptor: (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... Authors: Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. Deposit date: 2018-09-26 Release date: 2019-06-12 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.76 Å) Cite: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
6HAX	Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB Descriptor: (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. Deposit date: 2018-08-09 Release date: 2019-06-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.35 Å) Cite: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
6IC8	Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2 Descriptor: PHD finger protein 3, TYR-SEP-PRO-THR-SER-PRO-SER-TYR-SEP-PRO-THR Authors: Grishkovskaya, I, Djinovic-Carugo, K, Slade, D. Deposit date: 2018-12-02 Release date: 2020-07-15 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (1.929 Å) Cite: PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC Nat Commun, 12, 2021
6HAY	Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB Descriptor: (2~{S},4~{R})-~{N}-[[2-[2-[2-[2-[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. Deposit date: 2018-08-09 Release date: 2019-06-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.24 Å) Cite: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
4J04	Crystal structure of hcv ns5b polymerase in complex with 4-CHLORO-2-{[(2,4,5-TRICHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID Descriptor: 4-chloro-2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}benzoic acid, Genome polyprotein, MANGANESE (II) ION Authors: Coulombe, R. Deposit date: 2013-01-30 Release date: 2013-04-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
7V2Z	ZIKV NS3helicase in complex with ssRNA and ATP-Mn2+ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Core protein, MANGANESE (II) ION, ... Authors: Lin, M.M, Yang, H.T. Deposit date: 2021-08-10 Release date: 2022-08-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.10101676 Å) Cite: Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis. Acs Infect Dis., 8, 2022
3MAQ	Crystal structure of E.coli Pol II-normal DNA-dGTP ternary complex Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*CP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... Authors: Yang, W, Wang, F. Deposit date: 2010-03-24 Release date: 2010-04-07 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insight into translesion synthesis by DNA Pol II Cell(Cambridge,Mass.), 139, 2009
6XKI	Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A analog Descriptor: (3S,6Z,8E,11S,15R)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ... Authors: Liang, J, Naineni, S.K, Pelletier, J, Nagar, B. Deposit date: 2020-06-26 Release date: 2021-01-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A. Cell Chem Biol, 28, 2021
3K57	Crystal structure of E.coli Pol II-normal DNA-dATP ternary complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*G*TP*AP*TP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*G)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), ... Authors: Yang, W, Wang, F. Deposit date: 2009-10-06 Release date: 2010-02-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Structural insight into translesion synthesis by DNA Pol II Cell(Cambridge,Mass.), 139, 2009
3K58	Crystal structure of E.coli Pol II-normal DNA-dTTP ternary complex Descriptor: DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*AP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), DNA polymerase II, ... Authors: Yang, W, Wang, F. Deposit date: 2009-10-06 Release date: 2010-02-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural insight into translesion synthesis by DNA Pol II Cell(Cambridge,Mass.), 139, 2009
3K5L	Crystal structure of E.coli Pol II-abasic DNA-dATP Lt(0, 3) ternary complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*TP*(3DR)P*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... Authors: Yang, W, Wang, F. Deposit date: 2009-10-07 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
2JLX	Dengue virus 4 NS3 helicase in complex with ssRNA and ADP-Vanadate Descriptor: 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. Deposit date: 2008-09-15 Release date: 2008-11-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
2JLY	Dengue virus 4 NS3 helicase in complex with ssRNA and ADP-Phosphate Descriptor: 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... Authors: Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. Deposit date: 2008-09-15 Release date: 2008-11-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
2JLV	Dengue virus 4 NS3 helicase in complex with ssRNA and AMPPNP Descriptor: 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', CHLORIDE ION, GLYCEROL, ... Authors: Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. Deposit date: 2008-09-15 Release date: 2008-11-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein Embo J., 27, 2008
2JLZ	Dengue virus 4 NS3 helicase in complex with ssRNA and ADP Descriptor: 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. Deposit date: 2008-09-15 Release date: 2008-11-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
2ZVK	Crystal structure of PCNA in complex with DNA polymerase eta fragment Descriptor: DNA polymerase eta, Proliferating cell nuclear antigen Authors: Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. Deposit date: 2008-11-11 Release date: 2009-02-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
2ZVM	Crystal structure of PCNA in complex with DNA polymerase iota fragment Descriptor: DNA polymerase iota, Proliferating cell nuclear antigen Authors: Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. Deposit date: 2008-11-11 Release date: 2009-02-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
2ZVL	Crystal structure of PCNA in complex with DNA polymerase kappa fragment Descriptor: DNA polymerase kappa, Proliferating cell nuclear antigen, SULFATE ION, ... Authors: Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. Deposit date: 2008-11-11 Release date: 2009-02-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009

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