1XB4

Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II

Summary for 1XB4

• Entry DOI: 10.2210/pdb1xb4/pdb
• Descriptor: Hypothetical 23.6 kDa protein in YUH1-URA8 intergenic region (2 entities in total)
• Functional Keywords: winged helix, unknown function
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Cytoplasm : P47142
• Total number of polymer chains: 4
• Total formula weight: 94330.60

Authors

Weissenhorn, W.,Wernimont, A.K. (deposition date: 2004-08-27, release date: 2005-03-22, Last modification date: 2024-02-14)

Primary citation

Wernimont, A.K.,Weissenhorn, W.
Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II.
BMC Struct.Biol., 4:10-10, 2004

PubMed Abstract: Down-regulation of plasma membrane receptors via the endocytic pathway involves their monoubiquitylation, transport to endosomal membranes and eventual sorting into multi vesicular bodies (MVB) destined for lysosomal degradation. Successive assemblies of Endosomal Sorting Complexes Required for Transport (ESCRT-I, -II and III) largely mediate sorting of plasma membrane receptors at endosomal membranes, the formation of multivesicular bodies and their release into the endosomal lumen. In addition, the human ESCRT-II has been shown to form a complex with RNA polymerase II elongation factor ELL in order to exert transcriptional control activity.

PubMed: 15579210
DOI: 10.1186/1472-6807-4-10

Experimental method

X-RAY DIFFRACTION (3.1 Å)