5T5T
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![BU of 5t5t by Molmil](/molmil-images/mine/5t5t) | AMPK bound to allosteric activator | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | Authors: | Calabrese, M.F, Kurumbail, R.G. | Deposit date: | 2016-08-31 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.46 Å) | Cite: | Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J. Pharmacol. Exp. Ther., 361, 2017
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1RWP
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![BU of 1rwp by Molmil](/molmil-images/mine/1rwp) | |
1BSC
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![BU of 1bsc by Molmil](/molmil-images/mine/1bsc) | |
1RWX
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![BU of 1rwx by Molmil](/molmil-images/mine/1rwx) | |
1BSX
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![BU of 1bsx by Molmil](/molmil-images/mine/1bsx) | STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS | Descriptor: | 3,5,3'TRIIODOTHYRONINE, PROTEIN (GRIP1), PROTEIN (THYROID HORMONE RECEPTOR BETA) | Authors: | Wagner, R.L, Darimont, B.D, Apriletti, J.W, Stallcup, M.R, Kushner, P.J, Baxter, J.D, Fletterick, R.J, Yamamoto, K.R. | Deposit date: | 1998-08-31 | Release date: | 1999-08-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev., 12, 1998
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3K7G
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![BU of 3k7g by Molmil](/molmil-images/mine/3k7g) | Crystal structure of the Indian Hedgehog N-terminal signalling domain | Descriptor: | GLYCEROL, Indian hedgehog protein, SULFATE ION, ... | Authors: | He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. | Deposit date: | 2009-10-13 | Release date: | 2011-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of the Indian Hedgehog N-terminal signalling domain To be Published
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1S7Q
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![BU of 1s7q by Molmil](/molmil-images/mine/1s7q) | Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants | Descriptor: | Beta-2-microglobulin, Glycoprotein 9-residue peptide, H-2 class I histocompatibility antigen, ... | Authors: | Velloso, L.M, Michaelsson, J, Ljunggren, H.G, Schneider, G, Achour, A. | Deposit date: | 2004-01-30 | Release date: | 2004-05-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition. J.Immunol., 172, 2004
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1RZT
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![BU of 1rzt by Molmil](/molmil-images/mine/1rzt) | Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*CP*GP*GP*CP*AP*AP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*G)-3', ... | Authors: | Pedersen, L.C, Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Blanco, L, Kunkel, T.A. | Deposit date: | 2003-12-29 | Release date: | 2004-03-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Mol.Cell, 13, 2004
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1S7X
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![BU of 1s7x by Molmil](/molmil-images/mine/1s7x) | Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants | Descriptor: | Beta-2-microglobulin, Glycoprotein 9-residue peptide, H-2 class I histocompatibility antigen, ... | Authors: | Velloso, L.M, Michaelsson, J, Ljunggren, H.G, Schneider, G, Achour, A. | Deposit date: | 2004-01-30 | Release date: | 2004-05-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition. J.Immunol., 172, 2004
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5SVN
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![BU of 5svn by Molmil](/molmil-images/mine/5svn) | Structure of IDH2 mutant R172K | Descriptor: | DI(HYDROXYETHYL)ETHER, Isocitrate dehydrogenase [NADP], mitochondrial, ... | Authors: | Xie, X, Kulathila, R. | Deposit date: | 2016-08-06 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
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5SVZ
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![BU of 5svz by Molmil](/molmil-images/mine/5svz) | |
1CB0
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![BU of 1cb0 by Molmil](/molmil-images/mine/1cb0) | |
5JRT
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5SV7
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![BU of 5sv7 by Molmil](/molmil-images/mine/5sv7) | The Crystal structure of a chaperone | Descriptor: | Eukaryotic translation initiation factor 2-alpha kinase 3 | Authors: | Wang, P, Li, J, Sha, B. | Deposit date: | 2016-08-04 | Release date: | 2017-03-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.209 Å) | Cite: | The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins. Acta Crystallogr D Struct Biol, 72, 2016
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1SC4
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5TC8
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![BU of 5tc8 by Molmil](/molmil-images/mine/5tc8) | Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-DADMe-Immucillin-A | Descriptor: | (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C. | Deposit date: | 2016-09-14 | Release date: | 2017-10-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | TBA To be published
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5JXD
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![BU of 5jxd by Molmil](/molmil-images/mine/5jxd) | Crystal structure of murine Tnfaip8 C165S mutant | Descriptor: | Tumor necrosis factor alpha-induced protein 8, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Park, J, Kim, M.S, Lee, D, Shin, D.H. | Deposit date: | 2016-05-13 | Release date: | 2017-06-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.029 Å) | Cite: | The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin Sci Rep, 7, 2017
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3KA0
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![BU of 3ka0 by Molmil](/molmil-images/mine/3ka0) | |
4X5V
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![BU of 4x5v by Molmil](/molmil-images/mine/4x5v) | Crystal structure of the post-catalytic nick complex of DNA polymerase lambda with a templating A and incorporated 8-oxo-dGMP | Descriptor: | CITRIC ACID, DNA (5'-D(*CP*AP*GP*TP*AP*CP*(8OG))-3'), DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3'), ... | Authors: | Burak, M.J, Guja, K.E, Garcia-Diaz, M. | Deposit date: | 2014-12-05 | Release date: | 2015-10-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda. Nucleic Acids Res., 43, 2015
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4X61
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![BU of 4x61 by Molmil](/molmil-images/mine/4x61) | Crystal structure of PRMT5:MEP50 with EPZ015666 and SAM | Descriptor: | GLYCEROL, Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
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1U0F
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![BU of 1u0f by Molmil](/molmil-images/mine/1u0f) | Crystal structure of mouse phosphoglucose isomerase in complex with glucose 6-phosphate | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, BETA-MERCAPTOETHANOL, GLUCOSE-6-PHOSPHATE, ... | Authors: | Solomons, J.T.G, Zimmerly, E.M, Burns, S, Krishnamurthy, N, Swan, M.K, Krings, S, Muirhead, H, Chirgwin, J, Davies, C. | Deposit date: | 2004-07-13 | Release date: | 2004-11-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. J.Mol.Biol., 342, 2004
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3JS5
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![BU of 3js5 by Molmil](/molmil-images/mine/3js5) | |
3K23
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![BU of 3k23 by Molmil](/molmil-images/mine/3k23) | Glucocorticoid Receptor with Bound D-prolinamide 11 | Descriptor: | 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide, Glucocorticoid receptor, Nuclear receptor coactivator 2 | Authors: | Biggadike, K.B, McLay, I.M, Madauss, K.P, Williams, S.P, Bledsoe, R.K. | Deposit date: | 2009-09-29 | Release date: | 2009-10-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor. Proc.Natl.Acad.Sci.USA, 106, 2009
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5TM3
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![BU of 5tm3 by Molmil](/molmil-images/mine/5tm3) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 2,3-bis(2-chloro-4-hydroxyphenyl)thiophene 1-oxide | Descriptor: | (1S)-2,3-bis(2-chloro-4-hydroxyphenyl)-1H-1lambda~4~-thiophen-1-one, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. | Deposit date: | 2016-10-12 | Release date: | 2017-01-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
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5TML
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![BU of 5tml by Molmil](/molmil-images/mine/5tml) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC compound, (E)-6-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)hex-5-enoic acid | Descriptor: | 6-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}hex-5-enoic acid, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. | Deposit date: | 2016-10-13 | Release date: | 2017-01-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
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