5JRT

Crystal structure of the human Tankyrase 2 (TNKS2) SAM domain (DH902/924RE)

Summary for 5JRT

Entry DOI	10.2210/pdb5jrt/pdb
Descriptor	Tankyrase-2 (2 entities in total)
Functional Keywords	tankyrase polymerisation wnt signalling poly(adp-ribose)polymerase (parp), transferase, signalling protein, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	1
Total formula weight	8801.16
Authors	Guettler, S.,Mariotti, L.,Cronin, N. (deposition date: 2016-05-06, release date: 2016-08-03, Last modification date: 2016-08-17)
Primary citation	Mariotti, L.,Templeton, C.M.,Ranes, M.,Paracuellos, P.,Cronin, N.,Beuron, F.,Morris, E.,Guettler, S. Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling. Mol.Cell, 63:498-513, 2016 Cited by PubMed: 27494558 DOI: 10.1016/j.molcel.2016.06.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation