Glucocorticoid Receptor with Bound D-prolinamide 11

Summary for 3K23

DescriptorGlucocorticoid receptor, Nuclear receptor coactivator 2, 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide, ... (4 entities in total)
Functional Keywordsglucocorticoid receptor, steroid hormone receptor, nuclear receptor, gr, glucocorticoids, alpha helical sandwich, meta-channel, alternative initiation, chromatin regulator, disease mutation, dna-binding, metal-binding, nucleus, pseudohermaphroditism, receptor, steroid-binding, transcription, transcription regulation, zinc-finger, activator
Biological sourceHomo sapiens (human)
Cellular locationIsoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus  P04150
Nucleus Q15596
Total number of polymer chains6
Total molecular weight96360.85
Biggadike, K.B.,McLay, I.M.,Madauss, K.P.,Williams, S.P.,Bledsoe, R.K. (deposition date: 2009-09-29, release date: 2009-10-27, Last modification date: 2017-11-01)
Primary citation
Biggadike, K.,Bledsoe, R.K.,Coe, D.M.,Cooper, T.W.,House, D.,Iannone, M.A.,Macdonald, S.J.,Madauss, K.P.,McLay, I.M.,Shipley, T.J.,Taylor, S.J.,Tran, T.B.,Uings, I.J.,Weller, V.,Williams, S.P.
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Proc.Natl.Acad.Sci.USA, 106:18114-18119, 2009
PubMed: 19822747 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0909125106
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.238141.9%4.2%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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