3K23

Glucocorticoid Receptor with Bound D-prolinamide 11

Summary for 3K23

• Entry DOI: 10.2210/pdb3k23/pdb
• Related: 3K22
• Descriptor: Glucocorticoid receptor, Nuclear receptor coactivator 2, 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide, ... (4 entities in total)
• Functional Keywords: glucocorticoid receptor, steroid hormone receptor, nuclear receptor, gr, glucocorticoids, alpha helical sandwich, meta-channel, alternative initiation, chromatin regulator, disease mutation, dna-binding, metal-binding, nucleus, pseudohermaphroditism, receptor, steroid-binding, transcription, transcription regulation, zinc-finger, activator
• Biological source: Homo sapiens (human)
• Cellular location: Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150; Nucleus: Q15596
• Total number of polymer chains: 6
• Total formula weight: 96360.85

Authors

Biggadike, K.B.,McLay, I.M.,Madauss, K.P.,Williams, S.P.,Bledsoe, R.K. (deposition date: 2009-09-29, release date: 2009-10-27, Last modification date: 2024-04-03)

• Primary citation: Biggadike, K.,Bledsoe, R.K.,Coe, D.M.,Cooper, T.W.,House, D.,Iannone, M.A.,Macdonald, S.J.,Madauss, K.P.,McLay, I.M.,Shipley, T.J.,Taylor, S.J.,Tran, T.B.,Uings, I.J.,Weller, V.,Williams, S.P.; Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.; Proc.Natl.Acad.Sci.USA, 106:18114-18119, 2009; PubMed: 19822747; DOI: 10.1073/pnas.0909125106

Experimental method

X-RAY DIFFRACTION (3 Å)