3K23
Glucocorticoid Receptor with Bound D-prolinamide 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, B, C) | Glucocorticoid receptor | polymer | 259 | 29985.8 | 3 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B, D, F (D, E, F) | Nuclear receptor coactivator 2 | polymer | 12 | 1478.8 | 3 | UniProt (Q15596) | NCoA-2, Transcriptional intermediary factor 2, hTIF2 | |
| 3 | G, H, I (A, B, C) | 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide | non-polymer | 655.7 | 3 | Chemie (JZN) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B, C: 521 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Tyr 602 | Phe 602 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 94393.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1967.0 | |
| All* | Total formula weight | 96360.8 |
