3K23
Glucocorticoid Receptor with Bound D-prolinamide 11
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Glucocorticoid receptor | polymer | 259 | 29985.8 | 3 | UniProt (P04150) Pfam (PF00104) In PDB | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
2 | D, E, F | Nuclear receptor coactivator 2 | polymer | 12 | 1478.8 | 3 | UniProt (Q15596) In PDB | NCoA-2, Transcriptional intermediary factor 2, hTIF2 | |
3 | A, B, C | 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide | non-polymer | 655.7 | 3 | Chemie (JZN) | |||
4 | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B, C: 521 - 777 (UniProt: P04150)
PDB | External Database | Details |
---|---|---|
Gly 519 | - | expression tag |
Ser 520 | - | expression tag |
Tyr 602 | Phe 602 | engineered mutation |
Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 94393.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1967.0 | |
All* | Total formula weight | 96360.8 |