3K22

Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide

Summary for 3K22

• Entry DOI: 10.2210/pdb3k22/pdb
• Related: 3K23
• Descriptor: Glucocorticoid receptor, Transcriptional Intermediary Factor 2, N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]amino}-1H-indazol-1-yl)benzamide, ... (5 entities in total)
• Functional Keywords: glucocorticoid receptor, steroid hormone receptor, nuclear receptor, gr, glucocorticoids, alpha helical sandwich, meta-channel, alternative initiation, chromatin regulator, disease mutation, dna-binding, isopeptide bond, lipid-binding, metal-binding, nucleus, phosphoprotein, pseudohermaphroditism, receptor, steroid-binding, transcription, transcription regulation, zinc-finger
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 64756.99

Authors

Biggadike, K.B.,McLay, I.M.,Madauss, K.P.,Williams, S.P.,Bledsoe, R.K. (deposition date: 2009-09-29, release date: 2010-08-11, Last modification date: 2024-03-13)

• Primary citation: Biggadike, K.,Bledsoe, R.K.,Coe, D.M.,Cooper, T.W.,House, D.,Iannone, M.A.,Macdonald, S.J.,Madauss, K.P.,McLay, I.M.,Shipley, T.J.,Taylor, S.J.,Tran, T.B.,Uings, I.J.,Weller, V.,Williams, S.P.; Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.; Proc.Natl.Acad.Sci.USA, 106:18114-18119, 2009; PubMed: 19822747; DOI: 10.1073/pnas.0909125106

Experimental method

X-RAY DIFFRACTION (2.1 Å)