3K22
Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Glucocorticoid receptor | polymer | 259 | 29985.8 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B, D (H, D) | Transcriptional Intermediary Factor 2 | polymer | 12 | 1478.8 | 2 | UniProt (by SIFTS) (Q15596) | ||
| 3 | E, G (A, B) | N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]amino}-1H-indazol-1-yl)benzamide | non-polymer | 517.4 | 2 | Chemie (JZS) | |||
| 4 | F, H, I (A, B) | hexyl beta-D-glucopyranoside | non-polymer | 264.3 | 3 | Chemie (JZR) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, B: 521 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Tyr 602 | Phe 602 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62929.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1827.8 | |
| All* | Total formula weight | 64757.0 |
