3K22
Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Glucocorticoid receptor | polymer | 259 | 29985.8 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B, D (H, D) | Transcriptional Intermediary Factor 2 | polymer | 12 | 1478.8 | 2 | UniProt (by SIFTS) (Q15596) | ||
| 3 | E, G (A, B) | N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]amino}-1H-indazol-1-yl)benzamide | non-polymer | 517.4 | 2 | Chemie (JZS) PubChem (46840169) | |||
| 4 | F, H, I (A, B) | hexyl beta-D-glucopyranoside | non-polymer | 264.3 | 3 | Chemie (JZR) PubChem (17753866) PubChem (25323117) PubChem (26470594) PubChem (67411650) PubChem (67413670) PubChem (69135463) PubChem (57031297) PubChem (171355) PubChem (67409435) PubChem (67410024) PubChem (67410681) PubChem (67410683) PubChem (67411125) PubChem (67412168) PubChem (67412175) PubChem (69572815) PubChem (69647610) PubChem (71317242) PubChem (181215) PubChem (92223463) PubChem (447027) PubChem (95162434) PubChem (95162435) PubChem (101527252) PubChem (118908285) PubChem (118908318) PubChem (4462283) PubChem (11288533) PubChem (12986433) PubChem (14656368) PubChem (174070873) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, B: 521 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Tyr 602 | Phe 602 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62929.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1827.8 | |
| All* | Total formula weight | 64757.0 |
