3U4R
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![BU of 3u4r by Molmil](/molmil-images/mine/3u4r) | Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides | Descriptor: | 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-N-({3-[(methylsulfonyl)amino]phenyl}sulfonyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, RNA-directed RNA polymerase | Authors: | Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannagrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | Deposit date: | 2011-10-10 | Release date: | 2011-12-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
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3U4O
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![BU of 3u4o by Molmil](/molmil-images/mine/3u4o) | Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides | Descriptor: | 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase | Authors: | Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannigrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | Deposit date: | 2011-10-10 | Release date: | 2011-12-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
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8PPV
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![BU of 8ppv by Molmil](/molmil-images/mine/8ppv) | Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches | Descriptor: | DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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8PPT
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![BU of 8ppt by Molmil](/molmil-images/mine/8ppt) | Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch | Descriptor: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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3VNV
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![BU of 3vnv by Molmil](/molmil-images/mine/3vnv) | Complex structure of viral RNA polymerase II | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2012-01-18 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Mechanism for template-independent terminal adenylation activity of Q beta replicase Structure, 20, 2012
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1FQZ
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![BU of 1fqz by Molmil](/molmil-images/mine/1fqz) | NMR VALIDATED MODEL OF DOMAIN IIID OF HEPATITIS C VIRUS INTERNAL RIBOSOME ENTRY SITE | Descriptor: | HEPATITIS C VIRUS IRES DOMAIN IIID | Authors: | Klinck, R, Westhof, E, Walker, S, Afshar, M, Collier, A, Aboul-ela, F. | Deposit date: | 2000-09-07 | Release date: | 2001-01-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A potential RNA drug target in the hepatitis C virus internal ribosomal entry site. RNA, 6, 2000
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8PPU
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![BU of 8ppu by Molmil](/molmil-images/mine/8ppu) | Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing three consecutive mismatches | Descriptor: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(C7R)P*(PST)P*(PST)P*(PST))-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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5N2G
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![BU of 5n2g by Molmil](/molmil-images/mine/5n2g) | Structure of the E9 DNA polymerase from vaccinia virus in complex with manganese | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Tarbouriech, N, Burmeister, W.P, Iseni, F. | Deposit date: | 2017-02-07 | Release date: | 2017-11-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding. Nat Commun, 8, 2017
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3W5P
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![BU of 3w5p by Molmil](/molmil-images/mine/3w5p) | Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives | Descriptor: | (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | Authors: | Masuno, H, Ikura, T, Ito, N. | Deposit date: | 2013-02-05 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
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3W5Q
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![BU of 3w5q by Molmil](/molmil-images/mine/3w5q) | Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives | Descriptor: | (5beta,9beta)-3-oxocholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | Authors: | Masuno, H, Ikura, T, Ito, N. | Deposit date: | 2013-02-05 | Release date: | 2013-06-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
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3W5R
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![BU of 3w5r by Molmil](/molmil-images/mine/3w5r) | Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives | Descriptor: | (3beta,5beta,9beta)-3-(acetyloxy)cholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | Authors: | Masuno, H, Ikura, T, Ito, N. | Deposit date: | 2013-02-06 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
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2LTO
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![BU of 2lto by Molmil](/molmil-images/mine/2lto) | TDRD3 complex | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, Tudor domain-containing protein 3 | Authors: | Sikorsky, T. | Deposit date: | 2012-05-30 | Release date: | 2013-01-16 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Recognition of asymmetrically dimethylated arginine by TDRD3. Nucleic Acids Res., 40, 2012
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3AGQ
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![BU of 3agq by Molmil](/molmil-images/mine/3agq) | Structure of viral polymerase form II | Descriptor: | Elongation factor Ts, Elongation factor Tu 1, LINKER, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2010-04-06 | Release date: | 2010-09-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts Proc.Natl.Acad.Sci.USA, 107, 2010
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6ZV3
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![BU of 6zv3 by Molmil](/molmil-images/mine/6zv3) | TFIIS N-terminal domain (TND) from human MED26 | Descriptor: | Mediator of RNA polymerase II transcription subunit 26 | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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4BJI
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![BU of 4bji by Molmil](/molmil-images/mine/4bji) | Sfc1-DBD | Descriptor: | TRANSCRIPTION FACTOR TAU SUBUNIT SFC1 | Authors: | Taylor, N.M.I, Baudin, F, von Scheven, G, Muller, C.W. | Deposit date: | 2013-04-18 | Release date: | 2013-07-31 | Last modified: | 2013-11-06 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | RNA Polymerase III-Specific General Transcription Factor Iiic Contains a Heterodimer Resembling Tfiif RAP30/RAP74. Nucleic Acids Res., 41, 2013
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8HPP
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![BU of 8hpp by Molmil](/molmil-images/mine/8hpp) | Crystal structure of human INTS3 with SAGE1 | Descriptor: | Integrator complex subunit 3, Sarcoma antigen 1 | Authors: | Deng, W, Wu, J, Lei, M. | Deposit date: | 2022-12-12 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Cancer-testis antigen SAGE1 is a pan-cancer master regulator of RNA polymerase II To Be Published
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2MOW
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![BU of 2mow by Molmil](/molmil-images/mine/2mow) | |
3W5T
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![BU of 3w5t by Molmil](/molmil-images/mine/3w5t) | Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives | Descriptor: | (3beta,5beta,9beta)-3-(propanoyloxy)cholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | Authors: | Masuno, H, Ikura, T, Ito, N. | Deposit date: | 2013-02-06 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
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2CLX
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![BU of 2clx by Molmil](/molmil-images/mine/2clx) | 4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects | Descriptor: | 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, CELL DIVISION PROTEIN KINASE 2 | Authors: | Krystof, V, Cankar, P, Frysova, I, Slouka, J, Kontopidis, G, Dzubak, P, Hajduch, M, Deazevedo, W.F, Paprskarova, M, Orsag, M, Rolcik, J, Latr, A, Fischer, P.M, Strnad, M. | Deposit date: | 2006-05-02 | Release date: | 2006-11-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 4-Arylazo-3,5-Diamino-1H-Pyrazole Cdk Inhibitors: Sar Study, Crystal Structure in Complex with Cdk2, Selectivity, and Cellular Effects J.Med.Chem., 49, 2006
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5TYZ
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![BU of 5tyz by Molmil](/molmil-images/mine/5tyz) | DNA Polymerase Mu Product Complex, Mn2+ (960 min) | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Jamsen, J.A, Wilson, S.H. | Deposit date: | 2016-11-21 | Release date: | 2017-08-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.977 Å) | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TYW
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![BU of 5tyw by Molmil](/molmil-images/mine/5tyw) | DNA Polymerase Mu Reactant Complex, Mn2+ (10 min) | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Jamsen, J.A, Wilson, S.H. | Deposit date: | 2016-11-21 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TYU
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![BU of 5tyu by Molmil](/molmil-images/mine/5tyu) | DNA Polymerase Mu Reactant Complex, Mn2+ (4 min) | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Jamsen, J.A, Wilson, S.H. | Deposit date: | 2016-11-21 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.048 Å) | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TYX
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![BU of 5tyx by Molmil](/molmil-images/mine/5tyx) | DNA Polymerase Mu Product Complex, Mn2+ (15 min) | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | Authors: | Jamsen, J.A, Wilson, S.H. | Deposit date: | 2016-11-21 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.948 Å) | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TYV
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![BU of 5tyv by Molmil](/molmil-images/mine/5tyv) | DNA Polymerase Mu Reactant Complex, Mn2+ (7.5 min) | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | Authors: | Jamsen, J.A, Wilson, S.H. | Deposit date: | 2016-11-21 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TYY
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![BU of 5tyy by Molmil](/molmil-images/mine/5tyy) | DNA Polymerase Mu Product Complex, Mn2+ (60 min) | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Jamsen, J.A, Wilson, S.H. | Deposit date: | 2016-11-21 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.931 Å) | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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