2BWW
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![BU of 2bww by Molmil](/molmil-images/mine/2bww) | His350Ala Escherichia coli Aminopeptidase P | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, AMINOPEPTIDASE P, CITRATE ANION, ... | Authors: | Graham, S.C, Guss, J.M. | Deposit date: | 2005-07-19 | Release date: | 2006-01-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Kinetic and Crystallographic Analysis of Mutant Escherichia Coli Aminopeptidase P: Insights Into Substrate Recognition and the Mechanism of Catalysis. Biochemistry, 45, 2006
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3FM3
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![BU of 3fm3 by Molmil](/molmil-images/mine/3fm3) | Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 | Descriptor: | FE (III) ION, Methionine aminopeptidase 2, SULFATE ION | Authors: | Alvarado, J.J, Russell, M, Zhang, A, Adams, J, Toro, R, Burley, S.K, Weiss, L.M, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-12-19 | Release date: | 2009-01-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Mol.Biochem.Parasitol., 168, 2009
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3FMQ
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![BU of 3fmq by Molmil](/molmil-images/mine/3fmq) | Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor fumagillin bound | Descriptor: | FE (III) ION, FUMAGILLIN, Methionine aminopeptidase 2, ... | Authors: | Alvarado, J.J, Russell, M, Zhang, A, Adams, J, Toro, R, Burley, S.K, Weiss, L.M, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-12-22 | Release date: | 2009-01-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Mol.Biochem.Parasitol., 168, 2009
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2BWT
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![BU of 2bwt by Molmil](/molmil-images/mine/2bwt) | Asp260Ala Escherichia coli Aminopeptidase P | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CITRATE ANION, MAGNESIUM ION, ... | Authors: | Graham, S.C, Guss, J.M. | Deposit date: | 2005-07-19 | Release date: | 2006-01-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Kinetic and Crystallographic Analysis of Mutant Escherichia Coli Aminopeptidase P: Insights Into Substrate Recognition and the Mechanism of Catalysis. Biochemistry, 45, 2006
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2BH3
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![BU of 2bh3 by Molmil](/molmil-images/mine/2bh3) | Zn substituted E. coli Aminopeptidase P in complex with product | Descriptor: | CITRATE ANION, LEUCINE, MAGNESIUM ION, ... | Authors: | Graham, S.C, Bond, C.S, Freeman, H.C, Guss, J.M. | Deposit date: | 2005-01-07 | Release date: | 2005-09-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Functional Implications of Metal Ion Selection in Aminopeptidase P, a Metalloprotease with a Dinuclear Metal Center. Biochemistry, 44, 2005
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2EA2
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![BU of 2ea2 by Molmil](/molmil-images/mine/2ea2) | h-MetAP2 complexed with A773812 | Descriptor: | 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2 | Authors: | Park, C.H. | Deposit date: | 2007-01-30 | Release date: | 2008-02-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids Bioorg.Med.Chem.Lett., 17, 2007
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2BB7
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![BU of 2bb7 by Molmil](/molmil-images/mine/2bb7) | |
2B3L
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![BU of 2b3l by Molmil](/molmil-images/mine/2b3l) | Crystal structure of type I human methionine aminopeptidase in the apo form | Descriptor: | ACETIC ACID, GLYCEROL, Methionine aminopeptidase 1, ... | Authors: | Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. | Deposit date: | 2005-09-20 | Release date: | 2005-11-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,). Biochemistry, 44, 2005
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3FMR
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![BU of 3fmr by Molmil](/molmil-images/mine/3fmr) | Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor TNP470 bound | Descriptor: | (1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate, FE (III) ION, Methionine aminopeptidase 2, ... | Authors: | Alvarado, J.J, Russell, M, Zhang, A, Adams, J, Toro, R, Burley, S.K, Weiss, L.M, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-12-22 | Release date: | 2009-01-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Mol.Biochem.Parasitol., 168, 2009
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1GCE
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![BU of 1gce by Molmil](/molmil-images/mine/1gce) | STRUCTURE OF THE BETA-LACTAMASE OF ENTEROBACTER CLOACAE GC1 | Descriptor: | BETA-LACTAMASE | Authors: | Crichlow, G.V, Kuzin, A.P, Nukaga, M, Sawai, T, Knox, J.R. | Deposit date: | 1999-05-17 | Release date: | 1999-08-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the extended-spectrum class C beta-lactamase of Enterobacter cloacae GC1, a natural mutant with a tandem tripeptide insertion. Biochemistry, 38, 1999
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2B3K
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![BU of 2b3k by Molmil](/molmil-images/mine/2b3k) | Crystal structure of Human Methionine Aminopeptidase Type I in the holo form | Descriptor: | ACETATE ION, COBALT (II) ION, GLYCEROL, ... | Authors: | Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. | Deposit date: | 2005-09-20 | Release date: | 2005-11-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,). Biochemistry, 44, 2005
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2B3H
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![BU of 2b3h by Molmil](/molmil-images/mine/2b3h) | Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site | Descriptor: | CHLORIDE ION, COBALT (II) ION, GLYCEROL, ... | Authors: | Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. | Deposit date: | 2005-09-20 | Release date: | 2005-11-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,). Biochemistry, 44, 2005
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3EBI
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![BU of 3ebi by Molmil](/molmil-images/mine/3ebi) | Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog | Descriptor: | (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, GLYCEROL, M1 family aminopeptidase, ... | Authors: | McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C. | Deposit date: | 2008-08-27 | Release date: | 2009-01-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106, 2009
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2EVC
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![BU of 2evc by Molmil](/molmil-images/mine/2evc) | |
2EWB
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![BU of 2ewb by Molmil](/molmil-images/mine/2ewb) | The crystal structure of Bovine Lens Leucine Aminopeptidase in complex with zofenoprilat | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CARBONATE ION, Cytosol aminopeptidase, ... | Authors: | Alterio, V, Pedone, C, De Simone, G. | Deposit date: | 2005-11-02 | Release date: | 2006-04-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Metal Ion Substitution in the Catalytic Site Greatly Affects the Binding of Sulfhydryl-Containing Compounds to Leucyl Aminopeptidase. Biochemistry, 45, 2006
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2EVM
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2DFI
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![BU of 2dfi by Molmil](/molmil-images/mine/2dfi) | Crystal structure of Pf-MAP(1-292)-C | Descriptor: | COBALT (II) ION, Methionine aminopeptidase | Authors: | Katagiri, Y, Takano, K, Chon, H, Matsumura, H, Koga, Y, Kanaya, S. | Deposit date: | 2006-03-01 | Release date: | 2007-03-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Conformational contagion in a protein: Structural properties of a chameleon sequence Proteins, 68, 2007
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1GYT
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![BU of 1gyt by Molmil](/molmil-images/mine/1gyt) | E. coli Aminopeptidase A (PepA) | Descriptor: | CARBONATE ION, CHLORIDE ION, CYTOSOL AMINOPEPTIDASE, ... | Authors: | Straeter, N. | Deposit date: | 2002-04-29 | Release date: | 2002-06-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-Ray Structure of Aminopeptidase a from Escherichia Coli and a Model for the Nucleoprotein Complex in Xer Site-Specific Recombination Embo J., 18, 1999
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2EVO
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![BU of 2evo by Molmil](/molmil-images/mine/2evo) | |
2EA4
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![BU of 2ea4 by Molmil](/molmil-images/mine/2ea4) | h-MetAP2 complexed with A797859 | Descriptor: | 2-(2-AMINOETHOXY)-3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2 | Authors: | Park, C.H. | Deposit date: | 2007-01-30 | Release date: | 2008-02-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids Bioorg.Med.Chem.Lett., 17, 2007
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2MAT
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![BU of 2mat by Molmil](/molmil-images/mine/2mat) | E.COLI METHIONINE AMINOPEPTIDASE AT 1.9 ANGSTROM RESOLUTION | Descriptor: | COBALT (II) ION, PROTEIN (METHIONINE AMINOPEPTIDASE), SODIUM ION | Authors: | Lowther, W.T, Orville, A.M, Madden, D.T, Lim, S, Rich, D.H, Matthews, B.W. | Deposit date: | 1999-03-29 | Release date: | 1999-06-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis. Biochemistry, 38, 1999
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2OAZ
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![BU of 2oaz by Molmil](/molmil-images/mine/2oaz) | Human Methionine Aminopeptidase-2 Complexed with SB-587094 | Descriptor: | COBALT (II) ION, N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE, human Methionine Amino Peptidase 2 | Authors: | Marino Jr, J.P, Fisher, P.W, Hofmann, G.A, Kirkpatrick, R, Janson, C.A, Johnson, R.K, Ma, C, Mattern, M, Meek, T.D, Ryan, D, Schulz, C, Smith, W.W, Tew, D.G, Tomazek Jr, T.A, Veber, D.F, Xiong, W.C, Yamamoto, Y, Yamashita, K, Yang, G, Thompson, S.K. | Deposit date: | 2006-12-18 | Release date: | 2007-06-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J.Med.Chem., 50, 2007
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2GGC
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![BU of 2ggc by Molmil](/molmil-images/mine/2ggc) | Novel bacterial methionine aminopeptidase inhibitors | Descriptor: | COBALT (II) ION, METHIONINE, Methionine aminopeptidase, ... | Authors: | Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. | Deposit date: | 2006-03-23 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
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7SZK
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![BU of 7szk by Molmil](/molmil-images/mine/7szk) | Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex | Descriptor: | (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Shin, Y, Murakami, K.S. | Deposit date: | 2021-11-28 | Release date: | 2022-07-13 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
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2HB6
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![BU of 2hb6 by Molmil](/molmil-images/mine/2hb6) | Structure of Caenorhabditis elegans leucine aminopeptidase (LAP1) | Descriptor: | GLYCEROL, Leucine aminopeptidase 1, SODIUM ION, ... | Authors: | Patskovsky, Y, Zhan, C, Wengerter, B.C, Ramagopal, U, Milstein, S, Vidal, M, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-06-13 | Release date: | 2006-08-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Caenorhabditis Elegans Leucine Aminopeptidase To be Published
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