3FMQ

Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor fumagillin bound

Replaces:  3CMK

Summary for 3FMQ

• Entry DOI: 10.2210/pdb3fmq/pdb
• Related: 3FM3 3FMR
• Descriptor: Methionine aminopeptidase 2, FE (III) ION, FUMAGILLIN, ... (5 entities in total)
• Functional Keywords: methionine aminopeptidase type2, metap2, metap2 fumagillin complex, encephalitozoon cuniculi, structural genomics, psi-2, protein structure initiative, new york sgx research center for structural genomics, nysgxrc, aminopeptidase, cobalt, hydrolase, metal-binding, protease
• Biological source: Encephalitozoon cuniculi
• Total number of polymer chains: 2
• Total formula weight: 81491.57

Authors

Alvarado, J.J.,Russell, M.,Zhang, A.,Adams, J.,Toro, R.,Burley, S.K.,Weiss, L.M.,Almo, S.C.,New York SGX Research Center for Structural Genomics (NYSGXRC) (deposition date: 2008-12-22, release date: 2009-01-13, Last modification date: 2023-09-06)

• Primary citation: Alvarado, J.J.,Nemkal, A.,Sauder, J.M.,Russell, M.,Akiyoshi, D.E.,Shi, W.,Almo, S.C.,Weiss, L.M.; Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.; Mol.Biochem.Parasitol., 168:158-167, 2009; PubMed: 19660503; DOI: 10.1016/j.molbiopara.2009.07.008

Experimental method

X-RAY DIFFRACTION (2.5 Å)