2OAZ
Human Methionine Aminopeptidase-2 Complexed with SB-587094
Summary for 2OAZ
Entry DOI | 10.2210/pdb2oaz/pdb |
Descriptor | human Methionine Amino Peptidase 2, COBALT (II) ION, N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE, ... (4 entities in total) |
Functional Keywords | metap2, methionine, amino peptidase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41818.34 |
Authors | Marino Jr., J.P.,Fisher, P.W.,Hofmann, G.A.,Kirkpatrick, R.,Janson, C.A.,Johnson, R.K.,Ma, C.,Mattern, M.,Meek, T.D.,Ryan, D.,Schulz, C.,Smith, W.W.,Tew, D.G.,Tomazek Jr., T.A.,Veber, D.F.,Xiong, W.C.,Yamamoto, Y.,Yamashita, K.,Yang, G.,Thompson, S.K. (deposition date: 2006-12-18, release date: 2007-06-19, Last modification date: 2023-12-27) |
Primary citation | Marino, J.P.,Fisher, P.W.,Hofmann, G.A.,Kirkpatrick, R.B.,Janson, C.A.,Johnson, R.K.,Ma, C.,Mattern, M.,Meek, T.D.,Ryan, M.D.,Schulz, C.,Smith, W.W.,Tew, D.G.,Tomazek, T.A.,Veber, D.F.,Xiong, W.C.,Yamamoto, Y.,Yamashita, K.,Yang, G.,Thompson, S.K. Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J.Med.Chem., 50:3777-3785, 2007 Cited by PubMed: 17636946DOI: 10.1021/jm061182w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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