6MKB
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![BU of 6mkb by Molmil](/molmil-images/mine/6mkb) | Crystal structure of murine 4-1BB ligand | Descriptor: | SODIUM ION, SULFATE ION, Tumor necrosis factor ligand superfamily member 9, ... | Authors: | Bitra, A, Zajonc, D.M, Doukov, T. | Deposit date: | 2018-09-25 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding. J. Biol. Chem., 294, 2019
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7NX0
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![BU of 7nx0 by Molmil](/molmil-images/mine/7nx0) | LTK:ALKAL1 complex stabilized by a Nanobody | Descriptor: | ALK and LTK ligand 1, Leukocyte tyrosine kinase receptor, Nb3.16, ... | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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8GR6
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![BU of 8gr6 by Molmil](/molmil-images/mine/8gr6) | Crystal Structure of pilus-specific Sortase C from Streptococcus sanguinis | Descriptor: | 1,2-ETHANEDIOL, SODIUM ION, Sortase-like protein, ... | Authors: | Yadav, S, Parijat, P, Krishnan, V. | Deposit date: | 2022-09-01 | Release date: | 2023-06-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Crystal structure of the pilus-specific sortase from early colonizing oral Streptococcus sanguinis captures an active open-lid conformation. Int.J.Biol.Macromol., 243, 2023
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6MIY
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![BU of 6miy by Molmil](/molmil-images/mine/6miy) | Crystal structure of the mCD1d/xxa (JJ239)/iNKTCR ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | Authors: | Zajonc, D.M, Bitra, A, Janssens, J. | Deposit date: | 2018-09-20 | Release date: | 2019-01-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | 4"-O-Alkylated alpha-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies. ChemMedChem, 14, 2019
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6MJJ
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![BU of 6mjj by Molmil](/molmil-images/mine/6mjj) | Crystal structure of the mCD1d/xxm (JJ290) /iNKTCR ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zajonc, D.M, Bitra, A, Janssens, J. | Deposit date: | 2018-09-21 | Release date: | 2019-01-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | 4"-O-Alkylated alpha-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies. ChemMedChem, 14, 2019
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7O8A
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![BU of 7o8a by Molmil](/molmil-images/mine/7o8a) | diFe-sulerythrin reduced with Na-dithionite | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, FE (III) ION, ... | Authors: | Jeoung, J.-H, Dobbek, H. | Deposit date: | 2021-04-15 | Release date: | 2021-12-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Bimetallic Mn, Fe, Co, and Ni Sites in a Four-Helix Bundle Protein: Metal Binding, Structure, and Peroxide Activation. Inorg.Chem., 60, 2021
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7O9O
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7NTO
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![BU of 7nto by Molmil](/molmil-images/mine/7nto) | The structure of RRM domain of human TRMT2A at 1.23 A resolution | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ... | Authors: | Witzenberger, M, Janowski, R, Davydova, E, Niessing, D. | Deposit date: | 2021-03-10 | Release date: | 2022-01-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. Comput Struct Biotechnol J, 20, 2022
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1PE4
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![BU of 1pe4 by Molmil](/molmil-images/mine/1pe4) | SOLUTION STRUCTURE OF TOXIN CN12 FROM CENTRUROIDES NOXIUS ALFA SCORPION TOXIN ACTING ON SODIUM CHANNELS. NMR STRUCTURE | Descriptor: | Neurotoxin Cn11 | Authors: | Del Rio-Portilla, F, Hernandez-Marin, E, Pimienta, G, Coronas, F.V, Zamudio, F.Z, Rodrguez de la Vega, R.C, Wanke, E, Possani, L.D. | Deposit date: | 2003-05-21 | Release date: | 2004-05-25 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity. Eur.J.Biochem., 271, 2004
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7O0C
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![BU of 7o0c by Molmil](/molmil-images/mine/7o0c) | Human phosphomannomutase 2 (PMM2) wild-type in apo state | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Phosphomannomutase 2, ... | Authors: | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | Deposit date: | 2021-03-26 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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7O4G
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![BU of 7o4g by Molmil](/molmil-images/mine/7o4g) | Human phosphomannomutase 2 (PMM2) wild-type soaked with the activator glucose 1,6-bisphosphate | Descriptor: | 1,6-di-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | Authors: | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | Deposit date: | 2021-04-06 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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7O5Z
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![BU of 7o5z by Molmil](/molmil-images/mine/7o5z) | Human phosphomannomutase 2 (PMM2) with mutation T237M in apo state | Descriptor: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | Deposit date: | 2021-04-09 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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7O58
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![BU of 7o58 by Molmil](/molmil-images/mine/7o58) | Human phosphomannomutase 2 (PMM2) with mutation T237M in complex with the activator glucose 1,6-bisphosphate | Descriptor: | 1,6-di-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | Authors: | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | Deposit date: | 2021-04-08 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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7OEY
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![BU of 7oey by Molmil](/molmil-images/mine/7oey) | Neisseria gonnorhoeae variant E93Q at 1.35 angstrom resolution | Descriptor: | GLYCEROL, SODIUM ION, SUCCINIC ACID, ... | Authors: | Rabe von Pappenheim, F, Wensien, M, Tittmann, K. | Deposit date: | 2021-05-04 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Widespread occurrence of covalent lysine-cysteine redox switches in proteins. Nat.Chem.Biol., 18, 2022
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7OJE
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![BU of 7oje by Molmil](/molmil-images/mine/7oje) | Crystal structure of the covalent complex between Tribolium castaneum deubiquitinase ZUP and Ubiquitin-PA | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Lys-63-specific deubiquitinase ZUFSP, ... | Authors: | Pichlo, C, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2021-05-14 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nat Commun, 13, 2022
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8GPC
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![BU of 8gpc by Molmil](/molmil-images/mine/8gpc) | Crystal structure of NDM-1 at pH5.5 (Succinate) in complex with hydrolyzed ampicillin | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Metallo beta lactamase NDM-1, SODIUM ION, ... | Authors: | Shi, X, Dai, Y, Zhang, Q, Liu, W. | Deposit date: | 2022-08-26 | Release date: | 2023-08-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Interplay between the beta-lactam side chain and an active-site mobile loop of NDM-1 in penicillin hydrolysis as a potential target for mechanism-based inhibitor design. Int.J.Biol.Macromol., 262, 2024
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8IZJ
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7OIY
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![BU of 7oiy by Molmil](/molmil-images/mine/7oiy) | Crystal structure of the ZUFSP family member Mug105 | Descriptor: | SODIUM ION, Ubiquitin carboxyl-terminal hydrolase mug105 | Authors: | Pichlo, C, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2021-05-12 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nat Commun, 13, 2022
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7OIN
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![BU of 7oin by Molmil](/molmil-images/mine/7oin) | Crystal structure of LSSmScarlet - a genetically encoded red fluorescent protein with a large Stokes shift | Descriptor: | LSSmScarlet - Genetically Encoded Red Fluorescent Proteins with a Large Stokes Shift, SODIUM ION, SULFATE ION | Authors: | Boyko, K.M, Nikolaeva, A.Y, Dorovatovskii, P.V, Subach, O.M, Vlaskina, A.V, Agapova, Y.K, Ivashkina, O.I, Popov, V.O, Subach, F.V. | Deposit date: | 2021-05-12 | Release date: | 2022-02-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | LSSmScarlet, dCyRFP2s, dCyOFP2s and CRISPRed2s, Genetically Encoded Red Fluorescent Proteins with a Large Stokes Shift. Int J Mol Sci, 22, 2021
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8GKA
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![BU of 8gka by Molmil](/molmil-images/mine/8gka) | Human TRPV3 tetramer structure, closed conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | Authors: | Lansky, S, Betancourt, J.M, Scheuring, S. | Deposit date: | 2023-03-17 | Release date: | 2023-09-06 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | A pentameric TRPV3 channel with a dilated pore. Nature, 621, 2023
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7NXU
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![BU of 7nxu by Molmil](/molmil-images/mine/7nxu) | Crystal structure of the tick-borne encephalitis virus NS3 helicase in complex with ADP-Pi | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, NS3 helicase domain, ... | Authors: | Anindita, P.D, Grinkevich, P, Franta, Z. | Deposit date: | 2021-03-19 | Release date: | 2022-02-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanistic insight into the RNA-stimulated ATPase activity of tick-borne encephalitis virus helicase. J.Biol.Chem., 298, 2022
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7NTQ
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![BU of 7ntq by Molmil](/molmil-images/mine/7ntq) | Crystal structure of the SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, FORMIC ACID, ... | Authors: | Dupre, E, Villeret, V, Hanoulle, X. | Deposit date: | 2021-03-10 | Release date: | 2022-03-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.495 Å) | Cite: | Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses. Eur.J.Med.Chem., 250, 2023
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7OI2
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![BU of 7oi2 by Molmil](/molmil-images/mine/7oi2) | SaFtsz complexed with GDP (NaCl purification) | Descriptor: | 1,2-ETHANEDIOL, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu Morales, J.M. | Deposit date: | 2021-05-11 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics. Plos Biol., 20, 2022
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7NTT
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7NTW
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![BU of 7ntw by Molmil](/molmil-images/mine/7ntw) | |