7CWB
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7CWC
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6C3G
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1RHG
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7UNL
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![BU of 7unl by Molmil](/molmil-images/mine/7unl) | Human TMEM175 in an open state | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2022-04-11 | Release date: | 2022-06-01 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
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7TZJ
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![BU of 7tzj by Molmil](/molmil-images/mine/7tzj) | SARS CoV-2 PLpro in complex with inhibitor 3k | Descriptor: | DIMETHYL SULFOXIDE, N-[(3-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Papain-like protease, ... | Authors: | Calleja, D.J, Klemm, T, Lechtenberg, B.C, Kuchel, N.W, Lessene, G, Komander, D. | Deposit date: | 2022-02-15 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors. Front Chem, 10, 2022
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6RT0
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![BU of 6rt0 by Molmil](/molmil-images/mine/6rt0) | cryo-em structure of alpha-synuclein fibril polymorph 2A | Descriptor: | Alpha-synuclein | Authors: | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | Deposit date: | 2019-05-22 | Release date: | 2019-06-26 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
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7TVH
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6DHY
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7AB7
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![BU of 7ab7 by Molmil](/molmil-images/mine/7ab7) | Structure of Chloroflexus aggregans flavin based fluorescent protein (CagFbFP) I52T Q148K variant | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Multi-sensor hybrid histidine kinase, ... | Authors: | Remeeva, A, Nazarenko, V, Kovalev, K, Gushchin, I. | Deposit date: | 2020-09-06 | Release date: | 2021-04-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins. J.Biol.Chem., 296, 2021
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7AB6
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![BU of 7ab6 by Molmil](/molmil-images/mine/7ab6) | Structure of Chloroflexus aggregans flavin based fluorescent protein (CagFbFP) I52T variant | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Multi-sensor hybrid histidine kinase, ... | Authors: | Remeeva, A, Nazarenko, V, Kovalev, K, Gushchin, I. | Deposit date: | 2020-09-06 | Release date: | 2021-04-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins. J.Biol.Chem., 296, 2021
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7ABY
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![BU of 7aby by Molmil](/molmil-images/mine/7aby) | Crystal structure of iLOV-Q489K mutant | Descriptor: | ACETATE ION, FLAVIN MONONUCLEOTIDE, Phototropin-2 | Authors: | Granzin, J, Batra-Safferling, R. | Deposit date: | 2020-09-09 | Release date: | 2021-04-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins. J.Biol.Chem., 296, 2021
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6DHZ
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3N07
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![BU of 3n07 by Molmil](/molmil-images/mine/3n07) | Structure of putative 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Vibrio cholerae | Descriptor: | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, MAGNESIUM ION | Authors: | Liu, W, Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2010-05-13 | Release date: | 2010-08-04 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis. Biochemistry, 52, 2013
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1TJ7
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![BU of 1tj7 by Molmil](/molmil-images/mine/1tj7) | Structure determination and refinement at 2.44 A resolution of Argininosuccinate lyase from E. coli | Descriptor: | Argininosuccinate lyase, GLYCEROL, PHOSPHATE ION | Authors: | Bhaumik, P, Koski, M.K, Bergman, U, Wierenga, R.K. | Deposit date: | 2004-06-03 | Release date: | 2004-10-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli. Acta Crystallogr.,Sect.D, 60, 2004
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1TJL
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![BU of 1tjl by Molmil](/molmil-images/mine/1tjl) | Crystal structure of transcription factor DksA from E. coli | Descriptor: | DnaK suppressor protein, ZINC ION | Authors: | Perederina, A, Svetlov, V, Vassylyeva, M.N, Artsimovitch, I, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-06-06 | Release date: | 2004-09-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription Cell(Cambridge,Mass.), 118, 2004
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1VND
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![BU of 1vnd by Molmil](/molmil-images/mine/1vnd) | VND/NK-2 PROTEIN (HOMEODOMAIN), NMR | Descriptor: | VND/NK-2 PROTEIN | Authors: | Tsao, D.H.H, Gruschus, J.M, Wang, L.-H, Nirenberg, M, Ferretti, J.A. | Deposit date: | 1996-05-22 | Release date: | 1996-11-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The three-dimensional solution structure of the NK-2 homeodomain from Drosophila. J.Mol.Biol., 251, 1995
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7A9B
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![BU of 7a9b by Molmil](/molmil-images/mine/7a9b) | Crystal structure of Shank1 PDZ domain with ARAP3-derived peptide | Descriptor: | 1,2-ETHANEDIOL, SH3 and multiple ankyrin repeat domains protein 1,Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | Authors: | Mariam McAuley, M, Ali, M, Ivarsson, Y, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | Deposit date: | 2020-09-01 | Release date: | 2020-10-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Shank1 PDZ domain with ARAP3-derived peptide to be published
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6AK2
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![BU of 6ak2 by Molmil](/molmil-images/mine/6ak2) | Crystal structure of the syntenin PDZ1 domain in complex with the peptide inhibitor KSL-128018 | Descriptor: | Syntenin-1, peptide inhibitor KSL-128018 | Authors: | Jin, Z.Y, Park, J.H, Yun, J.H, Haugaard-Kedstrom, L.M, Lee, W.T. | Deposit date: | 2018-08-29 | Release date: | 2019-09-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.868 Å) | Cite: | A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J.Med.Chem., 64, 2021
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6I6E
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6EJT
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6AMI
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6I69
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8Q5K
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![BU of 8q5k by Molmil](/molmil-images/mine/8q5k) | PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand 2t : 2-(4-(3-((6-chloro-1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[(2~{S})-3-[[6-chloranyl-1-(2-methoxyethyl)benzimidazol-2-yl]amino]-2-oxidanyl-propoxy]phenyl]ethanenitrile, Multiple virulence factor regulator MvfR | Authors: | Markham-Lee, Z.J, Emsley, J. | Deposit date: | 2023-08-09 | Release date: | 2024-01-17 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Design, Synthesis, and Evaluation of New 1 H -Benzo[ d ]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections. J.Med.Chem., 67, 2024
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8FQ7
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![BU of 8fq7 by Molmil](/molmil-images/mine/8fq7) | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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