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8SI8
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BU of 8si8 by Molmil
Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in closed state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, ...
Authors:Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-04-14
Release date:2023-05-17
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Structural mechanisms of TRPM7 activation and inhibition.
Nat Commun, 14, 2023
8SI5
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BU of 8si5 by Molmil
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-8aH-4,8-methanobis[1]benzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ...
Authors:Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-04-14
Release date:2023-05-17
Method:ELECTRON MICROSCOPY (2.17 Å)
Cite:Structural mechanisms of TRPM7 activation and inhibition.
Nat Commun, 14, 2023
8SI6
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BU of 8si6 by Molmil
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in closed state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-8aH-4,8-methanobis[1]benzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ...
Authors:Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-04-14
Release date:2023-05-17
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Structural mechanisms of TRPM7 activation and inhibition.
Nat Commun, 14, 2023
8FOA
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BU of 8foa by Molmil
Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2022-12-30
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023
8FOB
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BU of 8fob by Molmil
Cryo-EM structure of human TRPV6 in the open state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ...
Authors:Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2022-12-30
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (2.71 Å)
Cite:Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023
7X6C
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BU of 7x6c by Molmil
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1
Descriptor: (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ...
Authors:Won, J, Jeong, H, Lee, H.H.
Deposit date:2022-03-07
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Nat Commun, 14, 2023
8SF0
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BU of 8sf0 by Molmil
Cryo-EM Structure of RyR1 + cAMP (Local Refinement of TMD)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEN
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BU of 8sen by Molmil
Cryo-EM Structure of RyR1
Descriptor: Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEW
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BU of 8sew by Molmil
Cryo-EM Structure of RyR1 + ADP (Local Refinement of TMD)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEX
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BU of 8sex by Molmil
Cryo-EM Structure of RyR1 + AMP (Local Refinement of TMD)
Descriptor: ADENOSINE MONOPHOSPHATE, Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SER
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BU of 8ser by Molmil
Cryo-EM Structure of RyR1 + Adenosine
Descriptor: ADENOSINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SES
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BU of 8ses by Molmil
Cryo-EM Structure of RyR1 + Adenine
Descriptor: ADENINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.98 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEP
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BU of 8sep by Molmil
Cryo-EM Structure of RyR1 + ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEO
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BU of 8seo by Molmil
Cryo-EM Structure of RyR1 + ATP-gamma-S
Descriptor: Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ...
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEZ
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BU of 8sez by Molmil
Cryo-EM Structure of RyR1 + Adenine (Local Refinement of TMD)
Descriptor: ADENINE, Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SET
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BU of 8set by Molmil
Cryo-EM Structure of RyR1 + cAMP
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEQ
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BU of 8seq by Molmil
Cryo-EM Structure of RyR1 + AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEY
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BU of 8sey by Molmil
Cryo-EM Structure of RyR1 + Adenosine (Local Refinement of TMD)
Descriptor: ADENOSINE, Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEV
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BU of 8sev by Molmil
Cryo-EM Structure of RyR1 + ATP-gamma-S (Local Refinement of TMD)
Descriptor: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEU
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BU of 8seu by Molmil
Cryo-EM Structure of RyR1 (Local Refinement of TMD)
Descriptor: Ryanodine receptor 1, ZINC ION
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8GVW
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BU of 8gvw by Molmil
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2
Descriptor: (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ...
Authors:Won, J, Jeong, H, Lee, H.H.
Deposit date:2022-09-16
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Nat Commun, 14, 2023
8GVX
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BU of 8gvx by Molmil
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2
Descriptor: (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Won, J, Jeong, H, Lee, H.H.
Deposit date:2022-09-16
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Nat Commun, 14, 2023
8EOI
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BU of 8eoi by Molmil
Structure of a human EMC:human Cav1.2 channel complex in GDN detergent
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L.
Deposit date:2022-10-03
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
8EOG
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BU of 8eog by Molmil
Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine
Descriptor: (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L.
Deposit date:2022-10-03
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
8DRP
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BU of 8drp by Molmil
Focus/local refined map in C4 of signal subtracted RyR1 particles
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, Ryanodine receptor 1, ...
Authors:Haji-Ghassemi, O, Van Petegm, F.
Deposit date:2022-07-21
Release date:2023-05-31
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation.
Sci Adv, 9, 2023

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