8SI8

Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in closed state

Summary for 8SI8

Entry DOI	10.2210/pdb8si8/pdb
Related	8SI2 8SI3 8SI4 8SI5 8SI6 8SI7
EMDB information	40496 40497 40498 40499 40500 40501 40502
Descriptor	Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, ... (6 entities in total)
Functional Keywords	transient receptor potential m family member 7, trp, channel, trpm7, trp channels, membrane protein, magnesium channel, n1098q, inhibitor, ligand, ver155008
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	633014.82
Authors	Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-04-14, release date: 2023-05-17, Last modification date: 2023-05-24)
Primary citation	Nadezhdin, K.D.,Correia, L.,Narangoda, C.,Patel, D.S.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I. Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14:2639-2639, 2023 Cited by PubMed: 37156763 DOI: 10.1038/s41467-023-38362-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.99 Å)

Structure validation