8SI8
Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in closed state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0051262 | biological_process | protein tetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0051262 | biological_process | protein tetramerization |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0051262 | biological_process | protein tetramerization |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0051262 | biological_process | protein tetramerization |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:37156763, ECO:0007744|PDB:8SI2 |
| Chain | Residue | Details |
| A | ALA851-VAL876 | |
| B | ALA851-VAL876 | |
| C | ALA851-VAL876 | |
| D | ALA851-VAL876 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | LYS877-PRO882 | |
| C | GLY944-HIS956 | |
| C | PRO1024-HIS1025 | |
| C | GLY1067-GLY1069 | |
| D | LYS877-PRO882 | |
| D | GLY944-HIS956 | |
| D | PRO1024-HIS1025 | |
| D | GLY1067-GLY1069 | |
| A | GLY944-HIS956 | |
| A | PRO1024-HIS1025 | |
| A | GLY1067-GLY1069 | |
| B | LYS877-PRO882 | |
| B | GLY944-HIS956 | |
| B | PRO1024-HIS1025 | |
| B | GLY1067-GLY1069 | |
| C | LYS877-PRO882 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:37156763, ECO:0007744|PDB:8SI2 |
| Chain | Residue | Details |
| A | SER883-VAL904 | |
| B | SER883-VAL904 | |
| C | SER883-VAL904 | |
| D | SER883-VAL904 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 144 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | PHE905-TYR923 | |
| A | ALA981-ASN999 | |
| B | PHE905-TYR923 | |
| B | ALA981-ASN999 | |
| C | PHE905-TYR923 | |
| C | ALA981-ASN999 | |
| D | PHE905-TYR923 | |
| D | ALA981-ASN999 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 76 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:37156763, ECO:0007744|PDB:8SI2 |
| Chain | Residue | Details |
| A | PHE924-PHE943 | |
| B | PHE924-PHE943 | |
| C | PHE924-PHE943 | |
| D | PHE924-PHE943 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 92 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:37156763, ECO:0007744|PDB:8SI2 |
| Chain | Residue | Details |
| A | VAL957-LEU980 | |
| B | VAL957-LEU980 | |
| C | VAL957-LEU980 | |
| D | VAL957-LEU980 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 92 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:37156763, ECO:0007744|PDB:8SI2 |
| Chain | Residue | Details |
| A | MET1000-TYR1023 | |
| B | MET1000-TYR1023 | |
| C | MET1000-TYR1023 | |
| D | MET1000-TYR1023 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 160 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:37156763, ECO:0007744|PDB:8SI2 |
| Chain | Residue | Details |
| A | GLU1026-CYS1066 | |
| B | GLU1026-CYS1066 | |
| C | GLU1026-CYS1066 | |
| D | GLU1026-CYS1066 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 112 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:37156763, ECO:0007744|PDB:8SI2 |
| Chain | Residue | Details |
| A | THR1070-GLN1098 | |
| B | THR1070-GLN1098 | |
| C | THR1070-GLN1098 | |
| D | THR1070-GLN1098 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96QT4 |
| Chain | Residue | Details |
| A | SER101 | |
| C | SER1191 | |
| C | SER1193 | |
| C | SER1258 | |
| D | SER101 | |
| D | SER1191 | |
| D | SER1193 | |
| D | SER1258 | |
| A | SER1191 | |
| A | SER1193 | |
| A | SER1258 | |
| B | SER101 | |
| B | SER1191 | |
| B | SER1193 | |
| B | SER1258 | |
| C | SER101 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q96QT4 |
| Chain | Residue | Details |
| A | THR1163 | |
| A | THR1265 | |
| B | THR1163 | |
| B | THR1265 | |
| C | THR1163 | |
| C | THR1265 | |
| D | THR1163 | |
| D | THR1265 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:22222377 |
| Chain | Residue | Details |
| A | SER1224 | |
| B | SER1224 | |
| C | SER1224 | |
| D | SER1224 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER1255 | |
| B | SER1255 | |
| C | SER1255 | |
| D | SER1255 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 12 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q96QT4 |
| Chain | Residue | Details |
| A | CYS1143 | |
| D | CYS1143 | |
| D | CYS1144 | |
| D | CYS1146 | |
| A | CYS1144 | |
| A | CYS1146 | |
| B | CYS1143 | |
| B | CYS1144 | |
| B | CYS1146 | |
| C | CYS1143 | |
| C | CYS1144 | |
| C | CYS1146 |
