8SI5
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open state
Summary for 8SI5
Entry DOI | 10.2210/pdb8si5/pdb |
Related | 8SI2 8SI3 8SI4 |
EMDB information | 40496 40497 40498 40499 |
Descriptor | Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, ... (7 entities in total) |
Functional Keywords | transient receptor potential m family member 7, trp, channel, trpm7, open state, trp channels, membrane protein, magnesium channel, agonist, ligand, naltriben |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 632395.08 |
Authors | Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-04-14, release date: 2023-05-17) |
Primary citation | Nadezhdin, K.D.,Correia, L.,Narangoda, C.,Patel, D.S.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I. Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14:2639-2639, 2023 Cited by PubMed: 37156763DOI: 10.1038/s41467-023-38362-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.17 Å) |
Structure validation
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