PDB: 8880 resultsInfo pagesStatus searchChemie searchBIRD

---

5G3W	Structure of HDAC like protein from Bordetella Alcaligenes in complex with the photoswitchable inhibitor CEW65 Descriptor: (2E)-N-hydroxy-3-{4-[(E)-phenyldiazenyl]phenyl}prop-2-enamide, DI(HYDROXYETHYL)ETHER, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-05-02 Release date: 2016-11-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. ACS Infect Dis, 3, 2017
5OO1	Cdk2(F80C, C177A) covalent adduct with C37 at F80C Descriptor: Cyclin-dependent kinase 2, ~{N}-(4-pyrimidin-2-ylphenyl)propanamide Authors: Craven, G, Morgan, R.M.L, Mann, D.J. Deposit date: 2017-08-04 Release date: 2018-08-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: High-throughput kinetic analysis for target-directed covalent ligand discovery To be published
5OM0	CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640 Descriptor: 14-3-3 protein sigma,Zinc finger protein GLI1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION Authors: Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. Deposit date: 2017-07-28 Release date: 2017-10-11 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
1RHW	The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila Descriptor: Dynein light chain 1, cytoplasmic Authors: Makokha, M, Huang, Y.J, Montelione, G, Edison, A.S, Barbar, E. Deposit date: 2003-11-14 Release date: 2004-04-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The solution structure of the pH-induced monomer of dynein light-chain LC8 from Drosophila. Protein Sci., 13, 2004
5QSE	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2017168803 Descriptor: (2S)-2-[(3-fluoropyridin-2-yl)(methyl)amino]propan-1-ol, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-25 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: PanDDA analysis group deposition To Be Published
5FUE	Crystal structure of Schistosoma mansoni HDAC8 complexed with 3- benzamido-benzohydroxamate Descriptor: 3-(benzoylamino)-N-oxobenzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... Authors: Marek, M, Romier, C. Deposit date: 2016-01-26 Release date: 2016-03-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.199 Å) Cite: Structure-Based Design and Synthesis of Novel Inhibitors Targeting Hdac8 from Schistosoma Mansoni for the Treatment of Schistosomiasis. J.Med.Chem., 59, 2016
5QSB	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2856434874 Descriptor: 1-{[4-(propan-2-yl)phenyl]methyl}piperidin-4-ol, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-25 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: PanDDA analysis group deposition To Be Published
6HRQ	Crystal structure of Schistosoma mansoni HDAC8 complexed with NCC-149 Descriptor: DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... Authors: Shaik, T.B, Marek, M, Romier, C. Deposit date: 2018-09-28 Release date: 2018-10-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.845 Å) Cite: Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HTI	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 6 Descriptor: GLYCEROL, Histone deacetylase, POTASSIUM ION, ... Authors: Shaik, T.B, Marek, M, Romier, C. Deposit date: 2018-10-04 Release date: 2018-10-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.693 Å) Cite: Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HTT	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 7 Descriptor: DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... Authors: Shaik, T.B, Marek, M, Romier, C. Deposit date: 2018-10-04 Release date: 2018-10-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.748 Å) Cite: Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HSK	Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat Descriptor: 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide, Histone deacetylase 8, POTASSIUM ION, ... Authors: Marek, M, Shaik, T.B, Ramos-Morales, E, Romier, C. Deposit date: 2018-10-01 Release date: 2018-10-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HSZ	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 2 Descriptor: 3-benzamido-4-methyl-~{N}-oxidanyl-benzamide, GLYCEROL, Histone deacetylase, ... Authors: Marek, M, Shaik, T.B, Romier, C. Deposit date: 2018-10-02 Release date: 2018-10-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.374 Å) Cite: Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
5QSH	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2856434868 Descriptor: 1-ethyl-N-(2-fluorophenyl)piperidin-4-amine, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-25 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: PanDDA analysis group deposition To Be Published
5QT0	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z321318226 Descriptor: N-(4-methoxyphenyl)-N'-pyridin-4-ylurea, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-26 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: PanDDA analysis group deposition To Be Published
5QSA	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2856434778 Descriptor: 2-(trifluoromethoxy)benzoic acid, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-25 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: PanDDA analysis group deposition To Be Published
5QSG	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2856434903 Descriptor: N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-25 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.87 Å) Cite: PanDDA analysis group deposition To Be Published
5GPD	Crystal structure of the binding domain of SREBP from fission yeast Descriptor: Sterol regulatory element-binding protein 1 Authors: Gong, X, Qian, H.W, Wu, J.P, Yan, N. Deposit date: 2016-08-01 Release date: 2016-11-23 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.501 Å) Cite: Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization Cell Res., 26, 2016
5GRS	Complex structure of the fission yeast SREBP-SCAP binding domains Descriptor: Sterol regulatory element-binding protein 1, Sterol regulatory element-binding protein cleavage-activating protein Authors: Gong, X, Qian, H.W, Wu, J.P, Yan, N. Deposit date: 2016-08-12 Release date: 2016-12-14 Last modified: 2019-10-23 Method: ELECTRON MICROSCOPY (5.4 Å) Cite: Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization Cell Res., 26, 2016
6JGM	Crystal structure of CDK2 IN complex with Inhibitor NU-6140 Descriptor: 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide, Cyclin-dependent kinase 2 Authors: SumalathaRani, T, Narasimharao, K. Deposit date: 2019-02-14 Release date: 2020-02-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of CDK2 IN complex with Inhibitor NU-6140 To Be Published
1FYH	1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR Descriptor: CHLORIDE ION, Interferon gamma, Interferon gamma receptor 1 Authors: Randal, M, Kossiakoff, A.A. Deposit date: 2000-09-29 Release date: 2000-10-11 Last modified: 2017-06-21 Method: X-RAY DIFFRACTION (2.04 Å) Cite: The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex. Structure, 9, 2001
1RDQ	Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Yang, J, Ten Eyck, L.F, Xuong, N.H, Taylor, S.S. Deposit date: 2003-11-05 Release date: 2004-04-13 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Crystal Structure of a cAMP-dependent Protein Kinase Mutant at 1.26A: New Insights into the Catalytic Mechanism. J.Mol.Biol., 336, 2004
5H6Y	The BPTF Bromodomain Recognising H4K12Cr peptide Descriptor: GLY-KCR-GLY, Nucleosome-remodeling factor subunit BPTF Authors: Wang, Y, Hao, Q. Deposit date: 2016-11-15 Release date: 2017-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: The BPTF Bromodomain Recognising H4K12Cr peptide To Be Published
5QS8	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z1432018343 Descriptor: (2S)-2-[(5-chloro-3-fluoropyridin-2-yl)amino]propan-1-ol, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-25 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.47 Å) Cite: PanDDA analysis group deposition To Be Published
1BH5	HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT Descriptor: LACTOYLGLUTATHIONE LYASE, S-HEXYLGLUTATHIONE, ZINC ION Authors: Cameron, A.D, Jones, T.A. Deposit date: 1998-06-13 Release date: 1998-11-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I. J.Biol.Chem., 273, 1998
5QSJ	PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z198194394 Descriptor: 4-(4-fluorophenyl)piperazine-1-carboxamide, T-box transcription factor T Authors: Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-05-25 Release date: 2019-08-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.49 Å) Cite: PanDDA analysis group deposition To Be Published

<285286287288289290291292293294295296297298299300>