5FUE

Crystal structure of Schistosoma mansoni HDAC8 complexed with 3- benzamido-benzohydroxamate

Summary for 5FUE

Entry DOI	10.2210/pdb5fue/pdb
Descriptor	HISTONE DEACETYLASE 8, ZINC ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywords	hydrolase, platyhelminths, inhibition, histone, deacetylation
Biological source	SCHISTOSOMA MANSONI
Total number of polymer chains	4
Total formula weight	204565.20
Authors	Marek, M.,Romier, C. (deposition date: 2016-01-26, release date: 2016-03-09, Last modification date: 2016-04-06)
Primary citation	Heimburg, T.,Chakrabarti, A.,Lancelot, J.,Marek, M.,Melesina, J.,Hauser, A.T.,Shaik, T.B.,Duclaud, S.,Robaa, D.,Erdmann, F.,Schmidt, M.,Romier, C.,Pierce, R.J.,Jung, M.,Sippl, W. Structure-Based Design and Synthesis of Novel Inhibitors Targeting Hdac8 from Schistosoma Mansoni for the Treatment of Schistosomiasis. J.Med.Chem., 59:2423-, 2016 Cited by PubMed: 26937828 DOI: 10.1021/ACS.JMEDCHEM.5B01478 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.199 Å)

Structure validation