5FUE
Crystal structure of Schistosoma mansoni HDAC8 complexed with 3- benzamido-benzohydroxamate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0004407 | molecular_function | histone deacetylase activity |
A | 0005634 | cellular_component | nucleus |
A | 0006338 | biological_process | chromatin remodeling |
A | 0046872 | molecular_function | metal ion binding |
B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
B | 0004407 | molecular_function | histone deacetylase activity |
B | 0005634 | cellular_component | nucleus |
B | 0006338 | biological_process | chromatin remodeling |
B | 0046872 | molecular_function | metal ion binding |
C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
C | 0004407 | molecular_function | histone deacetylase activity |
C | 0005634 | cellular_component | nucleus |
C | 0006338 | biological_process | chromatin remodeling |
C | 0046872 | molecular_function | metal ion binding |
D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
D | 0004407 | molecular_function | histone deacetylase activity |
D | 0005634 | cellular_component | nucleus |
D | 0006338 | biological_process | chromatin remodeling |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 500 |
Chain | Residue |
A | ASP186 |
A | HIS188 |
A | ASP285 |
A | UV4700 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 600 |
Chain | Residue |
A | ASP184 |
A | ASP186 |
A | HIS188 |
A | SER207 |
A | VAL208 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 601 |
Chain | Residue |
A | PHE197 |
A | SER200 |
A | VAL203 |
A | SER243 |
A | HOH2089 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE UV4 A 700 |
Chain | Residue |
A | LYS20 |
A | HIS141 |
A | HIS142 |
A | ASP186 |
A | HIS188 |
A | PHE216 |
A | ASP285 |
A | HIS292 |
A | GLY339 |
A | TYR341 |
A | ZN500 |
B | ASP50 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL A 800 |
Chain | Residue |
A | HIS188 |
A | HIS189 |
A | HIS210 |
A | ALA211 |
A | SER212 |
A | PHE215 |
A | PHE216 |
A | PRO217 |
A | GLY218 |
A | THR219 |
A | HOH2094 |
site_id | AC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 801 |
Chain | Residue |
A | HIS189 |
A | GLU194 |
A | THR219 |
A | GLY220 |
A | THR221 |
A | ASN223 |
A | PHE233 |
A | LEU234 |
A | ASN246 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 500 |
Chain | Residue |
B | ASP186 |
B | HIS188 |
B | ASP285 |
B | UV4700 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 600 |
Chain | Residue |
B | ASP184 |
B | ASP186 |
B | HIS188 |
B | SER207 |
B | VAL208 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 601 |
Chain | Residue |
B | PHE197 |
B | SER200 |
B | VAL203 |
B | SER243 |
B | HOH2068 |
site_id | BC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UV4 B 700 |
Chain | Residue |
A | ASP50 |
B | LYS20 |
B | HIS141 |
B | HIS142 |
B | GLY150 |
B | ASP186 |
B | HIS188 |
B | PHE216 |
B | ASP285 |
B | HIS292 |
B | GLY339 |
B | TYR341 |
B | ZN500 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 801 |
Chain | Residue |
B | HIS189 |
B | GLU194 |
B | GLY220 |
B | THR221 |
B | PHE233 |
B | LEU234 |
B | ASN246 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMF B 900 |
Chain | Residue |
B | TYR7 |
B | MET29 |
B | ASP30 |
B | ILE38 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMF B 901 |
Chain | Residue |
B | TYR301 |
B | ARG352 |
B | GLU359 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 500 |
Chain | Residue |
C | ASP186 |
C | HIS188 |
C | ASP285 |
C | UV4700 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K C 600 |
Chain | Residue |
C | ASP184 |
C | ASP186 |
C | HIS188 |
C | SER207 |
C | VAL208 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K C 601 |
Chain | Residue |
C | SER243 |
C | HOH2061 |
C | PHE197 |
C | SER200 |
C | VAL203 |
site_id | BC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE UV4 C 700 |
Chain | Residue |
C | LYS20 |
C | HIS141 |
C | HIS142 |
C | ASP186 |
C | HIS188 |
C | ASP285 |
C | PRO291 |
C | HIS292 |
C | GLY339 |
C | TYR341 |
C | ZN500 |
D | ASP50 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL C 800 |
Chain | Residue |
C | HIS189 |
C | GLU194 |
C | GLY220 |
C | THR221 |
C | PHE233 |
C | LEU234 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL C 801 |
Chain | Residue |
C | CYS15 |
C | PHE21 |
C | ARG24 |
C | TYR25 |
C | TYR110 |
C | TRP136 |
C | GLY137 |
C | HOH2009 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL C 802 |
Chain | Residue |
A | THR85 |
C | TYR35 |
C | LYS36 |
C | GLU40 |
C | LYS365 |
C | MET366 |
C | THR367 |
C | HOH2107 |
site_id | CC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMF C 900 |
Chain | Residue |
C | TYR7 |
C | MET29 |
C | ASP30 |
C | ILE38 |
site_id | CC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMF C 901 |
Chain | Residue |
C | TYR301 |
C | ARG352 |
C | LEU356 |
C | GLU359 |
C | MET366 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 500 |
Chain | Residue |
D | ASP186 |
D | HIS188 |
D | ASP285 |
D | UV4700 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K D 600 |
Chain | Residue |
D | ASP184 |
D | ASP186 |
D | HIS188 |
D | SER207 |
D | VAL208 |
site_id | CC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K D 601 |
Chain | Residue |
D | PHE197 |
D | SER200 |
D | VAL203 |
D | SER243 |
D | HOH2073 |
site_id | CC8 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE UV4 D 700 |
Chain | Residue |
C | ASP50 |
D | LYS20 |
D | HIS141 |
D | HIS142 |
D | ASP186 |
D | HIS188 |
D | ASP285 |
D | HIS292 |
D | GLY339 |
D | TYR341 |
D | ZN500 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL D 800 |
Chain | Residue |
D | TYR11 |
D | PRO46 |
D | GLN48 |
D | GLN116 |
site_id | DC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL D 801 |
Chain | Residue |
D | HIS189 |
D | GLU194 |
D | THR219 |
D | GLY220 |
D | THR221 |
D | ASN223 |
D | LEU234 |
site_id | DC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL D 803 |
Chain | Residue |
C | PRO291 |
C | HIS292 |
D | ASP50 |
D | SER51 |
D | SER53 |
D | ARG54 |
D | HOH2025 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMF D 901 |
Chain | Residue |
D | TYR301 |
D | ARG352 |
D | GLU359 |
D | MET366 |
D | ILE368 |