3E5V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3e5v by Molmil](/molmil-images/mine/3e5v) | Crystal Structure Analysis of eqFP611 Double Mutant T122R, N143S | Descriptor: | Red fluorescent protein eqFP611 | Authors: | Nar, H, Nienhaus, K, Nienhaus, U, Wiedenmann, J. | Deposit date: | 2008-08-14 | Release date: | 2008-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611. J.Am.Chem.Soc., 130, 2008
|
|
3IW5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3iw5 by Molmil](/molmil-images/mine/3iw5) | Human p38 MAP Kinase in Complex with an Indole Derivative | Descriptor: | Mitogen-activated protein kinase 14, N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide, octyl beta-D-glucopyranoside | Authors: | Gruetter, C, Simard, J.R, Rauh, D. | Deposit date: | 2009-09-02 | Release date: | 2009-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
|
|
3EHV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ehv by Molmil](/molmil-images/mine/3ehv) | |
2RQ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rq1 by Molmil](/molmil-images/mine/2rq1) | |
2R93
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2r93 by Molmil](/molmil-images/mine/2r93) | Elongation complex of RNA polymerase II with a hepatitis delta virus-derived RNA stem loop | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Lehmann, E, Brueckner, F, Cramer, P. | Deposit date: | 2007-09-12 | Release date: | 2007-11-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Molecular basis of RNA-dependent RNA polymerase II activity. Nature, 450, 2007
|
|
3ENS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ens by Molmil](/molmil-images/mine/3ens) | |
3IK9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ik9 by Molmil](/molmil-images/mine/3ik9) | Human GST A1-1-GIMF with GSDHN | Descriptor: | (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid, Glutathione S-transferase A1 | Authors: | Balogh, L.M, Le Trong, I, Atkins, W.M, Stenkamp, R.E. | Deposit date: | 2009-08-05 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. Biochemistry, 49, 2010
|
|
2RD6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rd6 by Molmil](/molmil-images/mine/2rd6) | PARP complexed with A861695 | Descriptor: | (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, Poly [ADP-ribose] polymerase 1 | Authors: | Park, C.H. | Deposit date: | 2007-09-21 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | PARP complexed with A861695 To be Published
|
|
3IM4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3im4 by Molmil](/molmil-images/mine/3im4) | Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2 | Descriptor: | Dual specificity A kinase-anchoring protein 2, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit | Authors: | Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. | Deposit date: | 2009-08-09 | Release date: | 2010-02-02 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.285 Å) | Cite: | Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity Structure, 18, 2010
|
|
2REA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rea by Molmil](/molmil-images/mine/2rea) | |
3IMT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3imt by Molmil](/molmil-images/mine/3imt) | Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromophenol | Descriptor: | 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromophenol, Transthyretin | Authors: | Connelly, S, Wilson, I. | Deposit date: | 2009-08-11 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
|
|
3EKZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ekz by Molmil](/molmil-images/mine/3ekz) | Structural Characterization of tetrameric Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase - substrate binding and catalysis mechanism of a class IIa bacterial aldolase | Descriptor: | 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase, SN-GLYCEROL-3-PHOSPHATE, ... | Authors: | Pegan, S, Rukseree, K, Franzblau, S.G, Mesecar, A.D. | Deposit date: | 2008-09-19 | Release date: | 2009-02-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis J.Mol.Biol., 386, 2009
|
|
2RG8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rg8 by Molmil](/molmil-images/mine/2rg8) | |
3EP4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ep4 by Molmil](/molmil-images/mine/3ep4) | Human AdoMetDC E256Q mutant with no putrescine bound | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRUVIC ACID, S-adenosylmethionine decarboxylase alpha chain, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
|
|
3IC0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ic0 by Molmil](/molmil-images/mine/3ic0) | Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298 | Descriptor: | 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | Authors: | Safo, M.K, Musayev, F.N, Gandhi, A.K, Jorge, P. | Deposit date: | 2009-07-17 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and in Vitro Chracterization of Pridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents To be Published
|
|
3ITZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3itz by Molmil](/molmil-images/mine/3itz) | |
2R64
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2r64 by Molmil](/molmil-images/mine/2r64) | Crystal structure of a 3-aminoindazole compound with CDK2 | Descriptor: | Cell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE | Authors: | Lee, J, Choi, H, Kim, K.H, Jeong, S, Park, J.W, Baek, C.S, Lee, S.H. | Deposit date: | 2007-09-05 | Release date: | 2008-09-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
|
|
3E5W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3e5w by Molmil](/molmil-images/mine/3e5w) | Crystal Structure Analysis of FP611 | Descriptor: | Red fluorescent protein eqFP611 | Authors: | Nienhaus, K, Nar, H, Heilker, R, Wiedenmann, J, Nienhaus, G.U. | Deposit date: | 2008-08-14 | Release date: | 2008-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611. J.Am.Chem.Soc., 130, 2008
|
|
3I7L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i7l by Molmil](/molmil-images/mine/3i7l) | Crystal Structure of DDB1 in Complex with the H-Box Motif of DDB2 | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2 | Authors: | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | Deposit date: | 2009-07-08 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
|
|
3E5S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3e5s by Molmil](/molmil-images/mine/3e5s) | |
3IFW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ifw by Molmil](/molmil-images/mine/3ifw) | |
3IA3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ia3 by Molmil](/molmil-images/mine/3ia3) | |
3EDZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3edz by Molmil](/molmil-images/mine/3edz) | Crystal structure of catalytic domain of TACE with hydroxamate inhibitor | Descriptor: | ADAM 17, CITRIC ACID, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... | Authors: | Mazzola, R.D, Zhu, Z, Sinning, L, McKittrick, B, Lavey, B, Spitler, J, Kozlowski, J, Neng-Yang, S, Zhou, G, Guo, Z, Orth, P, Madison, V, Sun, J, Lundell, D, Niu, X. | Deposit date: | 2008-09-03 | Release date: | 2008-09-23 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg.Med.Chem.Lett., 18, 2008
|
|
3EFG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3efg by Molmil](/molmil-images/mine/3efg) | Structure of SlyX protein from Xanthomonas campestris pv. campestris str. ATCC 33913 | Descriptor: | 1,2-ETHANEDIOL, Protein slyX homolog | Authors: | Cuff, M.E, Xu, X, Cui, H, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-09-08 | Release date: | 2008-12-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of SlyX protein from Xanthomonas campestris pv. campestris str. ATCC 33913 TO BE PUBLISHED
|
|
3II6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ii6 by Molmil](/molmil-images/mine/3ii6) | |