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3IMT

Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromophenol

Summary for 3IMT
Entry DOI10.2210/pdb3imt/pdb
Related2QGB 2QGC 2QGD 2QGE 3ESO 3ESP 3IMR 3IMS 3IMU 3IMV 3IMW
DescriptorTransthyretin, 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromophenol (3 entities in total)
Functional Keywordshormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28292.82
Authors
Connelly, S.,Wilson, I. (deposition date: 2009-08-11, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citationChoi, S.,Reixach, N.,Connelly, S.,Johnson, S.M.,Wilson, I.A.,Kelly, J.W.
A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc., 132:1359-1370, 2010
Cited by
PubMed: 20043671
DOI: 10.1021/ja908562q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

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