8QFW
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![BU of 8qfw by Molmil](/molmil-images/mine/8qfw) | Murine pyridoxal phosphatase in complex with 7,8-dihydroxyflavone | Descriptor: | 7,8-bis(oxidanyl)-2-phenyl-chromen-4-one, CITRIC ACID, Chronophin, ... | Authors: | Schindelin, H, Gohla, A. | Deposit date: | 2023-09-05 | Release date: | 2024-06-12 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase. Elife, 13, 2024
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5NZC
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8S8A
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![BU of 8s8a by Molmil](/molmil-images/mine/8s8a) | Human pyridoxal phosphatase in complex with 7,8-dihydroxyflavone without phosphate | Descriptor: | 7,8-bis(oxidanyl)-2-phenyl-chromen-4-one, CHLORIDE ION, Chronophin, ... | Authors: | Brenner, M, Gohla, A, Schindelin, H. | Deposit date: | 2024-03-06 | Release date: | 2024-06-12 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase. Elife, 13, 2024
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3E2B
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![BU of 3e2b by Molmil](/molmil-images/mine/3e2b) | Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow | Descriptor: | ACETATE ION, Dynein light chain 1, cytoplasmic, ... | Authors: | Benison, G, Barbar, E, Karplus, P.A. | Deposit date: | 2008-08-05 | Release date: | 2008-08-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The interplay of ligand binding and quaternary structure in the diverse interactions of dynein light chain LC8. J.Mol.Biol., 384, 2008
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3NCT
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![BU of 3nct by Molmil](/molmil-images/mine/3nct) | X-ray crystal structure of the bacterial conjugation factor PsiB, a negative regulator of reca | Descriptor: | Protein psiB | Authors: | Petrova, V, Satyshur, K.A, George, N.P, McCaslin, D, Cox, M.M, Keck, J.L. | Deposit date: | 2010-06-05 | Release date: | 2010-07-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray crystal structure of the bacterial conjugation factor PsiB, a negative regulator of RecA. J.Biol.Chem., 285, 2010
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3FCU
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![BU of 3fcu by Molmil](/molmil-images/mine/3fcu) | Structure of headpiece of integrin aIIBb3 in open conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, CALCIUM ION, ... | Authors: | Zhu, J, Luo, B.-H, Xiao, T, Zhang, C, Nishida, N, Springer, T.A. | Deposit date: | 2008-11-22 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol.Cell, 32, 2008
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3O0G
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![BU of 3o0g by Molmil](/molmil-images/mine/3o0g) | Crystal Structure of Cdk5:p25 in complex with an ATP analogue | Descriptor: | Cell division protein kinase 5, Cyclin-dependent kinase 5 activator 1, {4-amino-2-[(4-chlorophenyl)amino]-1,3-thiazol-5-yl}(3-nitrophenyl)methanone | Authors: | Mapelli, M. | Deposit date: | 2010-07-19 | Release date: | 2011-01-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Defining Cdk5 ligand chemical space with small molecule inhibitors of Tau phosphorylation Chem.Biol., 12, 2005
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7YGW
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![BU of 7ygw by Molmil](/molmil-images/mine/7ygw) | Crystal structure of the Zn2+-bound EFhd1/Swiprosin-2 | Descriptor: | EF-hand domain-containing protein D1, GLYCEROL, ZINC ION | Authors: | Mun, S.A, Park, J, Kang, J.Y, Park, T, Jin, M, Yang, J, Eom, S.H. | Deposit date: | 2022-07-12 | Release date: | 2023-03-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural and biochemical insights into Zn 2+ -bound EF-hand proteins, EFhd1 and EFhd2. Iucrj, 10, 2023
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7YGV
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![BU of 7ygv by Molmil](/molmil-images/mine/7ygv) | Crystal structure of the Ca2+-bound EFhd1/Swiprosin-2 | Descriptor: | CALCIUM ION, EF-hand domain-containing protein D1, GLYCEROL, ... | Authors: | Mun, S.A, Park, J, Kang, J.Y, Park, T, Jin, M, Ynag, J, Eom, S.H. | Deposit date: | 2022-07-12 | Release date: | 2023-03-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and biochemical insights into Zn 2+ -bound EF-hand proteins, EFhd1 and EFhd2. Iucrj, 10, 2023
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7YGY
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![BU of 7ygy by Molmil](/molmil-images/mine/7ygy) | Crystal structure of the Zn2+-bound EFhd2/Swiprosin-1 | Descriptor: | EF-hand domain-containing protein D2, ZINC ION | Authors: | Mun, S.A, Park, J, Kang, J.Y, Park, T, Jin, M, Yang, J, Eom, S.H. | Deposit date: | 2022-07-12 | Release date: | 2023-03-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and biochemical insights into Zn 2+ -bound EF-hand proteins, EFhd1 and EFhd2. Iucrj, 10, 2023
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6XML
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![BU of 6xml by Molmil](/molmil-images/mine/6xml) | Human aldolase A I98C | Descriptor: | Fructose-bisphosphate aldolase A, GLYCEROL, PHOSPHATE ION | Authors: | Meneely, K.M, Brewer, K, Lamb, A.L. | Deposit date: | 2020-06-30 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population. Protein Sci., 31, 2022
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6XMO
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![BU of 6xmo by Molmil](/molmil-images/mine/6xmo) | Human aldolase A I98F | Descriptor: | Fructose-bisphosphate aldolase A, GLYCEROL, PHOSPHATE ION | Authors: | Meneely, K.M, Lamb, A.L. | Deposit date: | 2020-06-30 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population. Protein Sci., 31, 2022
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6XMH
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![BU of 6xmh by Molmil](/molmil-images/mine/6xmh) | Human aldolase A wild type | Descriptor: | Fructose-bisphosphate aldolase A, GLYCEROL, PHOSPHATE ION | Authors: | Meneely, K.M, Lamb, A.L. | Deposit date: | 2020-06-30 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population. Protein Sci., 31, 2022
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6XMM
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![BU of 6xmm by Molmil](/molmil-images/mine/6xmm) | Human aldolase A I98S | Descriptor: | Fructose-bisphosphate aldolase A, GLYCEROL, PHOSPHATE ION | Authors: | Meneely, K.M, Brewer, K, Lamb, A.L. | Deposit date: | 2020-06-30 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population. Protein Sci., 31, 2022
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8XM7
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![BU of 8xm7 by Molmil](/molmil-images/mine/8xm7) | Cryo-EM structure of the RhoG/DOCK5/ELMO1/Rac1 complex: RhoG/DOCK5/ELMO1 focused map | Descriptor: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. | Deposit date: | 2023-12-27 | Release date: | 2024-06-26 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.91 Å) | Cite: | RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. J.Biol.Chem., 300, 2024
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1YIB
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![BU of 1yib by Molmil](/molmil-images/mine/1yib) | Crystal Structure of the Human EB1 C-terminal Dimerization Domain | Descriptor: | Microtubule-associated protein RP/EB family member 1 | Authors: | Slep, K.C, Rogers, S.L, Elliott, S.L, Ohkura, H, Kolodziej, P.A, Vale, R.D. | Deposit date: | 2005-01-11 | Release date: | 2005-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end J.Cell Biol., 168, 2005
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1YIG
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![BU of 1yig by Molmil](/molmil-images/mine/1yig) | Crystal Structure of the Human EB1 C-terminal Dimerization Domain | Descriptor: | Microtubule-associated protein RP/EB family member 1 | Authors: | Slep, K.C, Rogers, S.L, Elliott, S.L, Ohkura, H, Kolodziej, P.A, Vale, R.D. | Deposit date: | 2005-01-11 | Release date: | 2005-03-08 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end J.Cell Biol., 168, 2005
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6SB2
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![BU of 6sb2 by Molmil](/molmil-images/mine/6sb2) | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | Deposit date: | 2019-07-18 | Release date: | 2019-10-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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6SB0
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![BU of 6sb0 by Molmil](/molmil-images/mine/6sb0) | cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | Deposit date: | 2019-07-18 | Release date: | 2019-10-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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7TD3
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![BU of 7td3 by Molmil](/molmil-images/mine/7td3) | Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | Deposit date: | 2021-12-30 | Release date: | 2022-02-09 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD4
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![BU of 7td4 by Molmil](/molmil-images/mine/7td4) | Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod | Descriptor: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | Deposit date: | 2021-12-30 | Release date: | 2022-02-09 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7SWI
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![BU of 7swi by Molmil](/molmil-images/mine/7swi) | cTnC-TnI chimera complexed with A2 | Descriptor: | 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3R,4S)-7-fluoro-4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, Troponin C, slow skeletal and cardiac muscles,Troponin I, ... | Authors: | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | Deposit date: | 2021-11-19 | Release date: | 2022-04-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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7T6B
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![BU of 7t6b by Molmil](/molmil-images/mine/7t6b) | Structure of S1PR2-heterotrimeric G13 signaling complex | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Li, X, Chen, H. | Deposit date: | 2021-12-13 | Release date: | 2022-04-06 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structure of S1PR2-heterotrimeric G 13 signaling complex. Sci Adv, 8, 2022
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7SVC
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![BU of 7svc by Molmil](/molmil-images/mine/7svc) | NMR structure of cTnC-TnI chimera bound to calcium and A2 | Descriptor: | 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3R,4S)-7-fluoro-4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, CALCIUM ION, Troponin C, ... | Authors: | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | Deposit date: | 2021-11-18 | Release date: | 2022-04-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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7SUP
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![BU of 7sup by Molmil](/molmil-images/mine/7sup) | NMR structure of cTnC-TnI chimera bound to calcium and A1 | Descriptor: | 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3S)-7-fluoro-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, CALCIUM ION, Troponin C, ... | Authors: | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | Deposit date: | 2021-11-17 | Release date: | 2022-04-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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