2IPZ
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![BU of 2ipz by Molmil](/molmil-images/mine/2ipz) | A Parallel Coiled-Coil Tetramer with Offset Helices | Descriptor: | GLYCEROL, General control protein GCN4, ISOPROPYL ALCOHOL | Authors: | Liu, J, Lu, M. | Deposit date: | 2006-10-12 | Release date: | 2007-01-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A Parallel Coiled-Coil Tetramer with Offset Helices. Biochemistry, 45, 2006
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2V57
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![BU of 2v57 by Molmil](/molmil-images/mine/2v57) | Crystal structure of the TetR-like transcriptional regulator LfrR from Mycobacterium smegmatis in complex with proflavine | Descriptor: | ISOPROPYL ALCOHOL, PROFLAVIN, SULFATE ION, ... | Authors: | Bellinzoni, M, Buroni, S, Riccardi, G, De Rossi, E, Alzari, P.M. | Deposit date: | 2008-10-02 | Release date: | 2009-10-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Plasticity and Distinct Drug-Binding Modes of Lfrr, a Mycobacterial Efflux Pump Regulator. J.Bacteriol., 191, 2009
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7R3H
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![BU of 7r3h by Molmil](/molmil-images/mine/7r3h) | |
6ZUI
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![BU of 6zui by Molmil](/molmil-images/mine/6zui) | Crystal structure of the Cys-Ser mutant of the cpYFP-based biosensor for hypochlorous acid | Descriptor: | HTH-type transcriptional repressor NemR,Green fluorescent protein,Green fluorescent protein,HTH-type transcriptional repressor NemR | Authors: | Tossounian, M.A, Van Molle, I, Messens, J. | Deposit date: | 2020-07-23 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.200082 Å) | Cite: | Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives. Nat Commun, 13, 2022
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5YEG
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![BU of 5yeg by Molmil](/molmil-images/mine/5yeg) | Crystal structure of CTCF ZFs4-8-Hs5-1a complex | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*TP*AP*AP*CP*CP*AP*GP*CP*AP*GP*AP*GP*GP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*CP*CP*TP*CP*TP*GP*CP*TP*GP*GP*TP*TP*AP*AP*AP*G)-3'), Transcriptional repressor CTCF, ... | Authors: | Yin, M, Wang, J, Wang, M, Li, X. | Deposit date: | 2017-09-17 | Release date: | 2017-11-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites Cell Res., 27, 2017
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4U0V
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![BU of 4u0v by Molmil](/molmil-images/mine/4u0v) | |
3JSP
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![BU of 3jsp by Molmil](/molmil-images/mine/3jsp) | |
4U0W
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![BU of 4u0w by Molmil](/molmil-images/mine/4u0w) | |
4U0Y
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![BU of 4u0y by Molmil](/molmil-images/mine/4u0y) | |
6KCR
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![BU of 6kcr by Molmil](/molmil-images/mine/6kcr) | |
5J1U
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![BU of 5j1u by Molmil](/molmil-images/mine/5j1u) | Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-(furan-3-ylmethyl)pyrrolidine-1-carboxamide at 1.80A resolution | Descriptor: | EthR, N-[(furan-3-yl)methyl]pyrrolidine-1-carboxamide | Authors: | Blaszczyk, M, Surade, S, Nikiforov, P.O, Abell, C, Blundell, T.L. | Deposit date: | 2016-03-29 | Release date: | 2017-04-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. ACS Chem. Biol., 12, 2017
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5J1Y
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![BU of 5j1y by Molmil](/molmil-images/mine/5j1y) | Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution | Descriptor: | 3-[(3S)-oxolan-3-yl]-1-(pyrrolidin-1-yl)propan-1-one, EthR | Authors: | Blaszczyk, M, Surade, S, Nikiforov, P.O, Abell, C, Blundell, T.L. | Deposit date: | 2016-03-29 | Release date: | 2017-04-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. ACS Chem. Biol., 12, 2017
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5J3L
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![BU of 5j3l by Molmil](/molmil-images/mine/5j3l) | Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution | Descriptor: | 1-[(2-cyclopentylethyl)sulfonyl]pyrrolidine, HTH-type transcriptional regulator EthR | Authors: | Blaszczyk, M, Surade, S, Nikiforov, P.O, Abell, C, Blundell, T.L. | Deposit date: | 2016-03-31 | Release date: | 2017-03-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. ACS Chem. Biol., 12, 2017
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5MJE
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![BU of 5mje by Molmil](/molmil-images/mine/5mje) | Crystal structure of the HigB2 toxin in complex with Nb8 | Descriptor: | Cytotoxic translational repressor of toxin-antitoxin stability system, DI(HYDROXYETHYL)ETHER, Nanobody 8, ... | Authors: | Hadzi, S, Loris, R. | Deposit date: | 2016-11-30 | Release date: | 2017-04-05 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.599 Å) | Cite: | Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a beta-strand sliding mechanism. Nucleic Acids Res., 45, 2017
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5J1R
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![BU of 5j1r by Molmil](/molmil-images/mine/5j1r) | Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 3-(furan-3-yl)-1-(pyrrolidin-1-yl)propan-1-one at 1.92A resolution | Descriptor: | 3-(furan-3-yl)-1-(pyrrolidin-1-yl)propan-1-one, EthR | Authors: | Blaszczyk, M, Surade, S, Nikiforov, P.O, Abell, C, Blundell, T.L. | Deposit date: | 2016-03-29 | Release date: | 2017-03-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. ACS Chem. Biol., 12, 2017
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5N1I
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![BU of 5n1i by Molmil](/molmil-images/mine/5n1i) | |
2UXN
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![BU of 2uxn by Molmil](/molmil-images/mine/2uxn) | Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation | Descriptor: | CHLORIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Yang, M, Culhane, J.C, Szewczuk, L.M, Gocke, C.B, Brautigam, C.A, Tomchick, D.R, Machius, M, Cole, P.A, Yu, H. | Deposit date: | 2007-03-28 | Release date: | 2007-05-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation. Nat.Struct.Mol.Biol., 14, 2007
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1VPW
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![BU of 1vpw by Molmil](/molmil-images/mine/1vpw) | STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PURINE REPRESSOR | Authors: | Arvidson, D.N, Lu, F, Faber, C, Zalkin, H, Brennan, R.G. | Deposit date: | 1998-02-27 | Release date: | 1998-06-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of PurR mutant L54M shows an alternative route to DNA kinking. Nat.Struct.Biol., 5, 1998
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2VKV
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![BU of 2vkv by Molmil](/molmil-images/mine/2vkv) | TetR (BD) variant L17G with reverse phenotype | Descriptor: | 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, ... | Authors: | Resch, M, Striegl, H, Henssler, E.M, Sevvana, M, Egerer-Sieber, C, Schiltz, E, Hillen, W, Muller, Y.A. | Deposit date: | 2008-01-02 | Release date: | 2008-07-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | A Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr. Nucleic Acids Res., 36, 2008
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8R7Y
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![BU of 8r7y by Molmil](/molmil-images/mine/8r7y) | Deoxyribonucleoside regulator DeoR in complex with the DNA operator | Descriptor: | Deoxyribonucleoside regulator, OL18 DNA operator, strand 1, ... | Authors: | Pachl, P, Soltysova, M, Rezacova, P. | Deposit date: | 2023-11-27 | Release date: | 2024-06-19 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function. Nucleic Acids Res., 52, 2024
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6FAS
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![BU of 6fas by Molmil](/molmil-images/mine/6fas) | Crystal structure of VAL1 B3 domain in complex with cognate DNA | Descriptor: | B3 domain-containing transcription repressor VAL1, DNA (5'-D(*AP*GP*CP*CP*AP*TP*GP*CP*AP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*TP*GP*CP*AP*TP*GP*GP*CP*T)-3') | Authors: | Sasnauskas, G. | Deposit date: | 2017-12-17 | Release date: | 2018-04-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of DNA target recognition by the B3 domain of Arabidopsis epigenome reader VAL1. Nucleic Acids Res., 46, 2018
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5MWO
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![BU of 5mwo by Molmil](/molmil-images/mine/5mwo) | Structure of Mycobacterium Tuberculosis Transcriptional Regulatory Repressor Protein (EthR) in complex with fragment 7E8. | Descriptor: | (5-methyl-1-benzothiophen-2-yl)methanol, 1,2-ETHANEDIOL, HTH-type transcriptional regulator EthR | Authors: | Mendes, V, Chan, D.S.-H, Thomas, S.E, McConnell, B, Matak-Vinkovic, D, Coyne, A.G, Abell, C, Blundell, T.L. | Deposit date: | 2017-01-18 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.962 Å) | Cite: | Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry. Angew. Chem. Int. Ed. Engl., 56, 2017
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5MXK
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![BU of 5mxk by Molmil](/molmil-images/mine/5mxk) | Structure of Mycobacterium Tuberculosis Transcriptional Regulatory Repressor Protein (EthR) in complex with fragment 7G9. | Descriptor: | 1,2-ETHANEDIOL, HTH-type transcriptional regulator EthR, ~{N}-(5-oxidanylidene-7,8-dihydro-6~{H}-naphthalen-2-yl)ethanamide | Authors: | Mendes, V, Chan, D.S.-H, Thomas, S.E, McConnell, B, Matak-Vinkovic, D, Coyne, A.G, Abell, C, Blundell, T.L. | Deposit date: | 2017-01-23 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.932 Å) | Cite: | Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry. Angew. Chem. Int. Ed. Engl., 56, 2017
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6VYP
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![BU of 6vyp by Molmil](/molmil-images/mine/6vyp) | Crystal structure of the LSD1/CoREST histone demethylase bound to its nucleosome substrate | Descriptor: | DNA (191-MER), FLAVIN-ADENINE DINUCLEOTIDE, Histone H2A type 1, ... | Authors: | Kim, S, Zhu, J, Eek, P, Yennawar, N, Song, T. | Deposit date: | 2020-02-27 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.99 Å) | Cite: | Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate. Mol.Cell, 78, 2020
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2HGV
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![BU of 2hgv by Molmil](/molmil-images/mine/2hgv) | |