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6GR3
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BU of 6gr3 by Molmil
Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with AMPPNP
Descriptor: AMP PHOSPHORAMIDATE, Heat shock protein HSP 90-alpha, MAGNESIUM ION
Authors:Tassone, G, Pozzi, C, Mangani, S, Botta, M.
Deposit date:2018-06-08
Release date:2018-10-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
4YAZ
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BU of 4yaz by Molmil
3',3'-cGAMP riboswitch bound with 3',3'-cGAMP
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Ren, A.M, Patel, D.J, Rajashankar, R.K.
Deposit date:2015-02-18
Release date:2015-04-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Molecular Discrimination by a 3',3'-cGAMP Sensing Riboswitch.
Cell Rep, 11, 2015
4YB1
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BU of 4yb1 by Molmil
20A Mutant c-di-GMP Vc2 Riboswitch bound with 3',3'-cGAMP
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, MAGNESIUM ION, RNA (91-MER), ...
Authors:Ren, A.M, Patel, D.J, Rajashankar, R.K.
Deposit date:2015-02-18
Release date:2015-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.081 Å)
Cite:Structural Basis for Molecular Discrimination by a 3',3'-cGAMP Sensing Riboswitch.
Cell Rep, 11, 2015
6EA8
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BU of 6ea8 by Molmil
Structure of VACV poxin in pre-reactive state with nonhydrolyzable 2'3' cGAMP
Descriptor: (2S,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-dihydroxy-2,10-disulfanyloctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, O-[(1R,2R,3R)-5-{[(S)-{[(2R,3R,4R,5R)-2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydro furan-3-yl]oxy}(sulfanyl)phosphoryl]oxy}-1-(6-amino-9H-purin-9-yl)-1,2-dihydroxypentan-3-yl] dihydrogen (R)-phosphorothioate, Protein B2
Authors:Eaglesham, J.B, Kranzusch, P.J.
Deposit date:2018-08-02
Release date:2019-02-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
Nature, 566, 2019
2OOX
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BU of 2oox by Molmil
Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Hypothetical protein C1556.08c in chromosome I, SNF1-like protein kinase ssp2, ...
Authors:Townley, R, Shapiro, L.
Deposit date:2007-01-26
Release date:2007-02-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase.
Science, 315, 2007
3QOP
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BU of 3qop by Molmil
Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL
Authors:Knapp, J, White, M.A, Lee, J.C.
Deposit date:2011-02-10
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Domain-Domain Flexibility Leads to Allostery within the Camp Receptor Protein (Crp)
To be Published
6EP0
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BU of 6ep0 by Molmil
Enterococcus faecalis FIC protein in complex with AMP and calcium ion.
Descriptor: ADENOSINE MONOPHOSPHATE, CALCIUM ION, CHLORIDE ION, ...
Authors:Veyron, S, Cherfils, J.
Deposit date:2017-10-10
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins.
Nat Commun, 10, 2019
2QRC
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BU of 2qrc by Molmil
Crystal structure of the adenylate sensor from AMP-activated protein kinase in complex with ADP and AMP
Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Protein C1556.08c, ...
Authors:Jin, X, Townley, R, Shapiro, L.
Deposit date:2007-07-28
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Insight into AMPK Regulation: ADP Comes into Play.
Structure, 15, 2007
1LOI
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BU of 1loi by Molmil
N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES
Descriptor: CYCLIC 3',5'-AMP SPECIFIC PHOSPHODIESTERASE RD1
Authors:Smith, K.J, Scotland, G, Beattie, J, Trayer, I.P, Houslay, M.D.
Deposit date:1996-05-21
Release date:1997-05-15
Last modified:2024-10-23
Method:SOLUTION NMR
Cite:Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs.
J.Biol.Chem., 271, 1996
5AHW
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BU of 5ahw by Molmil
Crystal structure of universal stress protein MSMEG_3811 in complex with cAMP
Descriptor: (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CHLORIDE ION, ...
Authors:Adolph, R.S, Kleinboelting, S, Weyand, M, Steegborn, C.
Deposit date:2015-02-10
Release date:2015-04-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A Universal Stress Protein (Usp) in Mycobacteria Binds Camp
J.Biol.Chem., 290, 2015
4FBP
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BU of 4fbp by Molmil
CONFORMATIONAL TRANSITION OF FRUCTOSE-1,6-BISPHOSPHATASE: STRUCTURE COMPARISON BETWEEN THE AMP COMPLEX (T FORM) AND THE FRUCTOSE 6-PHOSPHATE COMPLEX (R FORM)
Descriptor: ADENOSINE MONOPHOSPHATE, FRUCTOSE 1,6-BISPHOSPHATASE
Authors:Ke, H, Zhang, Y, Liang, J.-Y, Lipscomb, W.N.
Deposit date:1991-02-11
Release date:1992-07-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational transition of fructose-1,6-bisphosphatase: structure comparison between the AMP complex (T form) and the fructose 6-phosphate complex (R form).
Biochemistry, 30, 1991
1RY2
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BU of 1ry2 by Molmil
Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, acetyl-coenzyme A synthetase 1
Authors:Jogl, G, Tong, L.
Deposit date:2003-12-19
Release date:2004-03-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP
Biochemistry, 43, 2004
5W10
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BU of 5w10 by Molmil
Lcd1 GAF domain in complex with cAMP ligand
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cGMP-specific phosphodiesterase
Authors:Guzzo, C.R, Maciel, N.K, Barbosa, A.S, Farah, C.S.
Deposit date:2017-06-01
Release date:2017-06-28
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and Enzymatic Characterization of a cAMP-Dependent Diguanylate Cyclase from Pathogenic Leptospira Species.
J. Mol. Biol., 429, 2017
2RIF
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BU of 2rif by Molmil
CBS domain protein PAE2072 from Pyrobaculum aerophilum complexed with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, CESIUM ION, Conserved protein with 2 CBS domains
Authors:Lee, T.M, King, N.P, Sawaya, M.R, Cascio, D, Yeates, T.O.
Deposit date:2007-10-10
Release date:2008-06-17
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures and Functional Implications of an AMP-Binding Cystathionine beta-Synthase Domain Protein from a Hyperthermophilic Archaeon.
J.Mol.Biol., 380, 2008
3U0Z
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BU of 3u0z by Molmil
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
Deposit date:2011-09-29
Release date:2011-10-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
6DT1
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BU of 6dt1 by Molmil
Crystal structure of the ligase from bacteriophage T4 complexed with DNA intermediate
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ...
Authors:Shi, K, Aihara, H.
Deposit date:2018-06-14
Release date:2018-09-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
Nucleic Acids Res., 46, 2018
5CFM
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BU of 5cfm by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p]
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CITRATE ANION, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
3U11
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BU of 3u11 by Molmil
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
Deposit date:2011-09-29
Release date:2011-10-26
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
4DG2
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BU of 4dg2 by Molmil
Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20
Descriptor: MYRISTIC ACID, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha
Authors:Bastidas, A.C, Steichen, J.M, Taylor, S.S.
Deposit date:2012-01-24
Release date:2012-06-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase.
J.Mol.Biol., 422, 2012
3U10
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BU of 3u10 by Molmil
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
Deposit date:2011-09-29
Release date:2011-10-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
4DG0
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BU of 4dg0 by Molmil
Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP
Descriptor: MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Bastidas, A.C, Steichen, J.M, Taylor, S.S.
Deposit date:2012-01-24
Release date:2012-06-06
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase.
J.Mol.Biol., 422, 2012
4DFX
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BU of 4dfx by Molmil
Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP
Descriptor: GLYCEROL, MAGNESIUM ION, MYRISTIC ACID, ...
Authors:Bastidas, A.C, Steichen, J.M, Taylor, S.S.
Deposit date:2012-01-24
Release date:2012-06-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase.
J.Mol.Biol., 422, 2012
4LEZ
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BU of 4lez by Molmil
Structure of mouse cGAS bound to an 18bp DNA and cGAS product
Descriptor: 18bp dsDNA, Cyclic GMP-AMP synthase, ZINC ION, ...
Authors:Li, P.
Deposit date:2013-06-26
Release date:2013-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
Immunity, 39, 2013
8BIK
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BU of 8bik by Molmil
Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455
Descriptor: (3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-[[6-chloranyl-5-[4-[4-[[dimethyl(oxidanyl)-$l^{4}-sulfanyl]amino]phenyl]phenyl]-3~{H}-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]furan-3-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ...
Authors:Schimpl, M, Mather, K.M, Boland, M.L, Rivers, E.L, Srivastava, A, Hemsley, P, Robinson, J, Wan, P.T, Hansen, J, Read, J.A, Trevaskis, J.L, Smith, D.M.
Deposit date:2022-11-02
Release date:2024-05-15
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Direct beta 1/ beta 2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis
Biorxiv, 2024
4K8V
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BU of 4k8v by Molmil
Structure of cyclic GMP-AMP Synthase (cGAS)
Descriptor: Cyclic GMP-AMP synthase, ZINC ION
Authors:Gao, P, Wu, Y, Patel, D.J.
Deposit date:2013-04-18
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013

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