4K8V
Structure of cyclic GMP-AMP Synthase (cGAS)
Summary for 4K8V
Entry DOI | 10.2210/pdb4k8v/pdb |
Related | 4K96 4K97 4K98 4K99 4K9A 4K9B |
Descriptor | Cyclic GMP-AMP synthase, ZINC ION (3 entities in total) |
Functional Keywords | nucleotidyltransferase, dna, transferase |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm, cytosol: Q8C6L5 |
Total number of polymer chains | 4 |
Total formula weight | 170310.12 |
Authors | Gao, P.,Wu, Y.,Patel, D.J. (deposition date: 2013-04-18, release date: 2013-05-15, Last modification date: 2024-02-28) |
Primary citation | Gao, P.,Ascano, M.,Wu, Y.,Barchet, W.,Gaffney, B.L.,Zillinger, T.,Serganov, A.A.,Liu, Y.,Jones, R.A.,Hartmann, G.,Tuschl, T.,Patel, D.J. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153:1094-1107, 2013 Cited by PubMed: 23647843DOI: 10.1016/j.cell.2013.04.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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