4K8V
Structure of cyclic GMP-AMP Synthase (cGAS)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 601 |
| Chain | Residue |
| C | HIS378 |
| C | CYS384 |
| C | CYS385 |
| C | CYS392 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 601 |
| Chain | Residue |
| A | HIS378 |
| A | CYS384 |
| A | CYS385 |
| A | CYS392 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 601 |
| Chain | Residue |
| B | CYS384 |
| B | CYS385 |
| B | CYS392 |
| B | HIS378 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 601 |
| Chain | Residue |
| D | HIS378 |
| D | CYS384 |
| D | CYS385 |
| D | CYS392 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843 |
| Chain | Residue | Details |
| C | THR197 | |
| A | SER199 | |
| A | GLU211 | |
| A | ASP213 | |
| A | ASP307 | |
| A | GLU371 | |
| A | LYS402 | |
| A | SER420 | |
| B | THR197 | |
| B | SER199 | |
| B | GLU211 | |
| C | SER199 | |
| B | ASP213 | |
| B | ASP307 | |
| B | GLU371 | |
| B | LYS402 | |
| B | SER420 | |
| D | THR197 | |
| D | SER199 | |
| D | GLU211 | |
| D | ASP213 | |
| D | ASP307 | |
| C | GLU211 | |
| D | GLU371 | |
| D | LYS402 | |
| D | SER420 | |
| C | ASP213 | |
| C | ASP307 | |
| C | GLU371 | |
| C | LYS402 | |
| C | SER420 | |
| A | THR197 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24332030, ECO:0007744|PDB:4LEZ |
| Chain | Residue | Details |
| C | GLY290 | |
| D | GLY290 | |
| D | LYS350 | |
| D | ARG364 | |
| C | LYS350 | |
| C | ARG364 | |
| A | GLY290 | |
| A | LYS350 | |
| A | ARG364 | |
| B | GLY290 | |
| B | LYS350 | |
| B | ARG364 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6X59, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
| Chain | Residue | Details |
| C | HIS378 | |
| C | CYS384 | |
| A | HIS378 | |
| A | CYS384 | |
| B | HIS378 | |
| B | CYS384 | |
| D | HIS378 | |
| D | CYS384 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6XJD, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
| Chain | Residue | Details |
| C | CYS385 | |
| A | CYS385 | |
| B | CYS385 | |
| D | CYS385 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911480, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6X5A, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
| Chain | Residue | Details |
| C | CYS392 | |
| A | CYS392 | |
| B | CYS392 | |
| D | CYS392 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Arginine-anchor => ECO:0000269|PubMed:31808743, ECO:0000269|PubMed:32911480, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000 |
| Chain | Residue | Details |
| C | ARG241 | |
| A | ARG241 | |
| B | ARG241 | |
| D | ARG241 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by CASP3 => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| C | ASP307 | |
| A | ASP307 | |
| B | ASP307 | |
| D | ASP307 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:35460603 |
| Chain | Residue | Details |
| C | GLU176 | |
| A | GLU176 | |
| B | GLU176 | |
| D | GLU176 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| C | SER199 | |
| A | SER199 | |
| B | SER199 | |
| D | SER199 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| C | TYR201 | |
| A | TYR201 | |
| B | TYR201 | |
| D | TYR201 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:26829768 |
| Chain | Residue | Details |
| C | GLU272 | |
| A | GLU272 | |
| B | GLU272 | |
| D | GLU272 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CDK1 and PKB => ECO:0000269|PubMed:26440888, ECO:0000269|PubMed:32351706 |
| Chain | Residue | Details |
| C | SER291 | |
| A | SER291 | |
| B | SER291 | |
| D | SER291 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: 5-glutamyl glutamate => ECO:0000269|PubMed:26829768 |
| Chain | Residue | Details |
| C | GLU302 | |
| A | GLU302 | |
| B | GLU302 | |
| D | GLU302 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| C | LYS372 | |
| D | LYS372 | |
| D | LYS382 | |
| D | LYS402 | |
| C | LYS382 | |
| C | LYS402 | |
| A | LYS372 | |
| A | LYS382 | |
| A | LYS402 | |
| B | LYS372 | |
| B | LYS382 | |
| B | LYS402 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:32474700 |
| Chain | Residue | Details |
| C | SER420 | |
| A | SER420 | |
| B | SER420 | |
| D | SER420 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:35210392 |
| Chain | Residue | Details |
| C | LYS491 | |
| A | LYS491 | |
| B | LYS491 | |
| D | LYS491 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 12 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| C | CYS392 | |
| D | CYS392 | |
| D | CYS393 | |
| D | CYS459 | |
| C | CYS393 | |
| C | CYS459 | |
| A | CYS392 | |
| A | CYS393 | |
| A | CYS459 | |
| B | CYS392 | |
| B | CYS393 | |
| B | CYS459 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:27637147 |
| Chain | Residue | Details |
| C | LYS217 | |
| A | LYS217 | |
| B | LYS217 | |
| D | LYS217 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27637147, ECO:0000269|PubMed:32457395 |
| Chain | Residue | Details |
| C | LYS464 | |
| A | LYS464 | |
| B | LYS464 | |
| D | LYS464 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27637147, ECO:0000269|PubMed:32457395 |
| Chain | Residue | Details |
| C | LYS271 | |
| A | LYS271 | |
| B | LYS271 | |
| D | LYS271 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:29426904 |
| Chain | Residue | Details |
| C | LYS335 | |
| A | LYS335 | |
| B | LYS335 | |
| D | LYS335 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| C | LYS372 | |
| A | LYS372 | |
| B | LYS372 | |
| D | LYS372 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:28095500 |
| Chain | Residue | Details |
| C | LYS382 | |
| A | LYS382 | |
| B | LYS382 | |
| D | LYS382 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| C | LYS399 | |
| C | LYS402 | |
| A | LYS399 | |
| A | LYS402 | |
| B | LYS399 | |
| B | LYS402 | |
| D | LYS399 | |
| D | LYS402 |
