2YDG
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![BU of 2ydg by Molmil](/molmil-images/mine/2ydg) | Ascorbate co-crystallized HEWL. | Descriptor: | ASCORBIC ACID, Lysozyme C, SODIUM ION | Authors: | De la Mora, E, Carmichael, I, Garman, E.F. | Deposit date: | 2011-03-19 | Release date: | 2011-07-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Effective Scavenging at Cryotemperatures: Further Increasing the Dose Tolerance of Protein Crystals. J.Synchrotron.Radiat., 18, 2011
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2VUR
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![BU of 2vur by Molmil](/molmil-images/mine/2vur) | Chemical dissection of the link between Streptozotocin, O-GlcNAc and pancreatic cell death | Descriptor: | 2-deoxy-2-{[(2-hydroxy-1-methylhydrazino)carbonyl]amino}-beta-D-glucopyranose, O-GLCNACASE NAGJ, SULFATE ION | Authors: | Pathak, S, Dorfmueller, H.C, Borodkin, V.S, van Aalten, D.M.F. | Deposit date: | 2008-05-29 | Release date: | 2009-02-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Chemical Dissection of the Link between Streptozotocin, O-Glcnac, and Pancreatic Cell Death. Chem.Biol., 15, 2008
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2Y92
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![BU of 2y92 by Molmil](/molmil-images/mine/2y92) | Crystal structure of MAL adaptor protein | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN, | Authors: | Valkov, E, Stamp, A, Martin, J.L, Kobe, B. | Deposit date: | 2011-02-11 | Release date: | 2011-09-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection. Proc.Natl.Acad.Sci.USA, 108, 2011
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3J9L
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![BU of 3j9l by Molmil](/molmil-images/mine/3j9l) | Structure of Dark apoptosome from Drosophila melanogaster | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apaf-1 related killer DARK | Authors: | Pang, Y, Bai, X, Yan, C, Hao, Q, Chen, Z, Wang, J, Scheres, S.H.W, Shi, Y. | Deposit date: | 2015-02-04 | Release date: | 2015-02-25 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila. Genes Dev., 29, 2015
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2YBN
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![BU of 2ybn by Molmil](/molmil-images/mine/2ybn) | |
2W1X
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![BU of 2w1x by Molmil](/molmil-images/mine/2w1x) | The interdependence of wavelength, redundancy and dose in sulfur SAD experiments: 1.284 A wavelength 360 images data | Descriptor: | CHLORIDE ION, LYSOZYME C, SODIUM ION | Authors: | Cianci, M, Helliwell, J.R, Suzuki, A. | Deposit date: | 2008-10-21 | Release date: | 2008-11-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Interdependence of Wavelength, Redundancy and Dose in Sulfur Sad Experiments. Acta Crystallogr.,Sect.D, 64, 2008
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2J3F
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![BU of 2j3f by Molmil](/molmil-images/mine/2j3f) | L-ficolin complexed to N-acetyl-D-galactosamine | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Garlatti, V, Gaboriaud, C. | Deposit date: | 2006-08-21 | Release date: | 2007-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J., 26, 2007
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2Y8D
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![BU of 2y8d by Molmil](/molmil-images/mine/2y8d) | STRUCTURE OF DBL6 EPSILON DOMAIN FROM VAR2CSA STRAIN FCR3 | Descriptor: | 2-AMINO-ETHANETHIOL, BENZAMIDINE, ERYTHROCYTE MEMBRANE PROTEIN 1 | Authors: | Gangnard, S, Ramboarina, S, Lewit-Bentley, A, Bentley, G.A. | Deposit date: | 2011-02-04 | Release date: | 2012-02-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structural and Immunological Correlations between the Variable Blocks of the Var2Csa Domain Dbl6Epsilon from Two Plasmodium Falciparum Parasite Lines. J.Mol.Biol., 425, 2013
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2W0D
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![BU of 2w0d by Molmil](/molmil-images/mine/2w0d) | Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases. | Descriptor: | ACETATE ION, CALCIUM ION, CHLORIDE ION, ... | Authors: | Isaksson, J, Nystrom, S, Derbyshire, D.J, Wallberg, H, Agback, T, Kovacs, H, Bertini, I, Felli, I.C. | Deposit date: | 2008-08-13 | Release date: | 2009-03-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? a Case Study of Metalloproteinases. J.Med.Chem., 52, 2009
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2VNN
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![BU of 2vnn by Molmil](/molmil-images/mine/2vnn) | Human BACE-1 in complex with 7-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-1- methyl-3,4-dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9- carboxamide 2,2-dioxide | Descriptor: | BETA-SECRETASE 1, N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-7-ethyl-1-methyl-3,4-dihydro-1H-[1,2,5]thiadiazepino[3,4,5-hi]indole-9-carboxamide 2,2-dioxide | Authors: | Charrier, N, Clarke, B, Cutler, L, Demont, E, Dingwall, C, Dunsdon, R, East, P, Hawkins, J, Howes, C, Hussain, I, Jeffrey, P, Maile, G, Matico, R, Mosley, J, Naylor, A, OBrien, A, Redshaw, S, Rowland, P, Soleil, V, Smith, K.J, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Wayne, G. | Deposit date: | 2008-02-05 | Release date: | 2008-05-20 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Second Generation of Hydroxyethylamine Bace-1 Inhibitors: Optimizing Potency and Oral Bioavailability. J.Med.Chem., 51, 2008
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2W3B
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![BU of 2w3b by Molmil](/molmil-images/mine/2w3b) | HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686) | Descriptor: | 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, FOLIC ACID, ... | Authors: | Leung, A.K.W, Reynolds, R.C, Borhani, D.W. | Deposit date: | 2008-11-11 | Release date: | 2009-11-17 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate To be Published
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2YBL
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![BU of 2ybl by Molmil](/molmil-images/mine/2ybl) | |
2J1X
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2J10
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![BU of 2j10 by Molmil](/molmil-images/mine/2j10) | p53 tetramerization domain mutant T329F Q331K | Descriptor: | CELLULAR TUMOR ANTIGEN P53 | Authors: | Carbajo, R.J, Mora, P, Sanchez del Pino, M.M, Perez-Paya, E, Pineda-Lucena, A. | Deposit date: | 2006-08-08 | Release date: | 2007-08-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach. Proteins, 71, 2008
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2J5W
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![BU of 2j5w by Molmil](/molmil-images/mine/2j5w) | Ceruloplasmin revisited: structural and functional roles of various metal cation binding sites | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CERULOPLASMIN, ... | Authors: | Bento, I, Peixoto, C, Zaitsev, V.N, Lindley, P.F. | Deposit date: | 2006-09-19 | Release date: | 2007-02-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ceruloplasmin Revisited: Structural and Functional Roles of Various Metal Cation-Binding Sites. Acta Crystallogr.,Sect.D, 63, 2007
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2IUH
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![BU of 2iuh by Molmil](/molmil-images/mine/2iuh) | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide | Descriptor: | C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT | Authors: | Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. | Deposit date: | 2006-06-03 | Release date: | 2006-06-06 | Last modified: | 2021-04-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
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2IUL
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![BU of 2iul by Molmil](/molmil-images/mine/2iul) | Human tACE g13 mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ANGIOTENSIN-CONVERTING ENZYME, ... | Authors: | Watermeyer, J.M, Sewell, B.T, Natesh, R, Corradi, H.R, Acharya, K.R, Sturrock, E.D. | Deposit date: | 2006-06-06 | Release date: | 2006-10-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure of Testis Ace Glycosylation Mutants and Evidence for Conserved Domain Movement. Biochemistry, 45, 2006
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2IVS
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![BU of 2ivs by Molmil](/molmil-images/mine/2ivs) | Crystal structure of non-phosphorylated RET tyrosine kinase domain | Descriptor: | 2',3'- cyclic AMP, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | Authors: | Knowles, P.P, Murray-Rust, J, McDonald, N.Q. | Deposit date: | 2006-06-16 | Release date: | 2006-08-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Chemical Inhibition of the Ret Tyrosine Kinase Domain. J.Biol.Chem., 281, 2006
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2YK0
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![BU of 2yk0 by Molmil](/molmil-images/mine/2yk0) | Structure of the N-terminal NTS-DBL1-alpha and CIDR-gamma double domain of the PfEMP1 protein from Plasmodium falciparum varO strain. | Descriptor: | ERYTHROCYTE MEMBRANE PROTEIN 1, MAGNESIUM ION, SULFATE ION | Authors: | Lewit-Bentley, A, Juillerat, A, Vigan-Womas, I, Guillotte, M, Hessel, A, Raynal, B, Mercereau-Puijalon, O, Bentley, G.A. | Deposit date: | 2011-05-25 | Release date: | 2012-05-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for the Abo Blood-Group Dependence of Plasmodium Falciparum Rosetting. Plos Pathog., 8, 2012
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3BAG
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![BU of 3bag by Molmil](/molmil-images/mine/3bag) | |
3BEI
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![BU of 3bei by Molmil](/molmil-images/mine/3bei) | Crystal structure of the slow form of thrombin in a self_inhibited conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Prothrombin | Authors: | Gandhi, P.S, Chen, Z, Mathews, F.S, Di Cera, E. | Deposit date: | 2007-11-19 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3JYH
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![BU of 3jyh by Molmil](/molmil-images/mine/3jyh) | Human dipeptidyl peptidase DPP7 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl-peptidase 2, ... | Authors: | Dobrovetsky, E, Dong, A, Seitova, A, Crombett, L, Paganon, S, Cossar, D, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Hassel, A, Shewchuk, L, Bochkarev, A, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-21 | Release date: | 2009-10-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Human dipeptidyl peptidase DPP7 To be Published
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3BGG
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![BU of 3bgg by Molmil](/molmil-images/mine/3bgg) | Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP | Descriptor: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Uridine 5'-monophosphate synthase | Authors: | Liu, Y, Tang, H.L, Wang, X.Y, Kotra, L.P, Pai, E.F. | Deposit date: | 2007-11-26 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP To be Published
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3BHV
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![BU of 3bhv by Molmil](/molmil-images/mine/3bhv) | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B | Descriptor: | 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol, Cell division protein kinase 2, Cyclin-A2, ... | Authors: | Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. | Deposit date: | 2007-11-29 | Release date: | 2008-02-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
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3BIM
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![BU of 3bim by Molmil](/molmil-images/mine/3bim) | |