2IVS

Crystal structure of non-phosphorylated RET tyrosine kinase domain

Summary for 2IVS

Entry DOI	10.2210/pdb2ivs/pdb
Related	2IVT 2IVU 2IVV
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, FORMIC ACID, 2',3'- cyclic AMP, ... (4 entities in total)
Functional Keywords	nucleotide-binding, hirschsprung disease, phosphorylation, disease mutation, phosphotransferase, tyrosine-protein kinase, chromosomal translocation, polymorphism, gdnf receptor, transmembrane, proto-oncogene, tyrosine kinase, ret, kinase, membrane, atp-binding, transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	72351.03
Authors	Knowles, P.P.,Murray-Rust, J.,McDonald, N.Q. (deposition date: 2006-06-16, release date: 2006-08-14, Last modification date: 2023-12-13)
Primary citation	Knowles, P.P.,Murray-Rust, J.,Kjaer, S.,Scott, R.P.,Hanrahan, S.,Santoro, M.,Ibanez, C.F.,McDonald, N.Q. Structure and Chemical Inhibition of the Ret Tyrosine Kinase Domain. J.Biol.Chem., 281:33577-33587, 2006 Cited by PubMed: 16928683 DOI: 10.1074/JBC.M605604200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation