8WQD
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5TRY
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![BU of 5try by Molmil](/molmil-images/mine/5try) | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206 | Descriptor: | (2~{S})-~{N}-[(2~{S})-3-methoxy-1-(naphthalen-1-ylmethylamino)-1-oxidanylidene-propan-2-yl]-4-oxidanylidene-2-(3-phenylpropanoylamino)-4-piperidin-1-yl-butanamide, Proteasome subunit alpha, Proteasome subunit beta | Authors: | Hsu, H.-C, Fan, H, Singh, P.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | Deposit date: | 2016-10-27 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.000008 Å) | Cite: | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry, 56, 2017
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5TOU
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![BU of 5tou by Molmil](/molmil-images/mine/5tou) | STRUCTURE OF C-PHYCOCYANIN FROM ARCTIC PSEUDANABAENA SP. LW0831 | Descriptor: | PHYCOCYANOBILIN, Phycocyanin alpha-1 subunit, Phycocyanin beta-1 subunit | Authors: | Wang, Q.M, Li, C.Y, Su, H.N, Zhang, Y.Z, Xie, B.B. | Deposit date: | 2016-10-18 | Release date: | 2017-03-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structural insights into the cold adaptation of the photosynthetic pigment-protein C-phycocyanin from an Arctic cyanobacterium Biochim. Biophys. Acta, 1858, 2017
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5TZG
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![BU of 5tzg by Molmil](/molmil-images/mine/5tzg) | Structure of the BldD CTD(D116A)-(c-di-GMP)2, form 2 | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein, ZINC ION | Authors: | Schumacher, M.A. | Deposit date: | 2016-11-21 | Release date: | 2017-04-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res., 45, 2017
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7CLZ
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6PTD
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![BU of 6ptd by Molmil](/molmil-images/mine/6ptd) | PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C MUTANT H32L | Descriptor: | PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C | Authors: | Heinz, D.W. | Deposit date: | 1997-07-18 | Release date: | 1998-01-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry, 36, 1997
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8WQI
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5W4S
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5E4F
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6LDP
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![BU of 6ldp by Molmil](/molmil-images/mine/6ldp) | Structure of CDK5R1-bound FEM1C | Descriptor: | Protein fem-1 homolog C,Peptide from Cyclin-dependent kinase 5 activator 1, SULFATE ION | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-22 | Release date: | 2020-10-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6UYD
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![BU of 6uyd by Molmil](/molmil-images/mine/6uyd) | Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | Authors: | Tzarum, N, Wilson, I.A, Zhu, J. | Deposit date: | 2019-11-13 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
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7MWC
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![BU of 7mwc by Molmil](/molmil-images/mine/7mwc) | ERAP1 binds peptide C-terminus of a LPF sequence (AAAAFKARKF) | Descriptor: | Endoplasmic reticulum aminopeptidase 1,LPF sequence | Authors: | Guo, H.C, Sui, L. | Deposit date: | 2021-05-16 | Release date: | 2021-07-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | ERAP1 binds peptide C-termini of different sequences and/or lengths by a common recognition mechanism. Immunobiology, 226, 2021
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6UYM
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![BU of 6uym by Molmil](/molmil-images/mine/6uym) | Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v6 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | Authors: | Tzarum, N, Wilson, I.A, Zhu, J. | Deposit date: | 2019-11-13 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.848 Å) | Cite: | Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
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7MWB
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![BU of 7mwb by Molmil](/molmil-images/mine/7mwb) | ERAP1 binds peptide C-terminus of a SPF sequence (FKARKF) | Descriptor: | Endoplasmic reticulum aminopeptidase 1,SPF Sequence | Authors: | Guo, H.C, Sui, L. | Deposit date: | 2021-05-16 | Release date: | 2021-07-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | ERAP1 binds peptide C-termini of different sequences and/or lengths by a common recognition mechanism. Immunobiology, 226, 2021
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6UYF
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![BU of 6uyf by Molmil](/molmil-images/mine/6uyf) | Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 6a bound to broadly neutralizing antibody AR3B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | Authors: | Tzarum, N, Wilson, I.A, Zhu, J. | Deposit date: | 2019-11-13 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
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7JYA
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![BU of 7jya by Molmil](/molmil-images/mine/7jya) | Crystal structure of E3 ligase in complex with peptide | Descriptor: | ASN-ARG-ARG-ARG-ARG-TRP-ARG-GLU-ARG-GLN-ARG, Protein fem-1 homolog C, UNKNOWN ATOM OR ION | Authors: | Yan, X, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Dong, C, Structural Genomics Consortium (SGC) | Deposit date: | 2020-08-30 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Molecular basis for ubiquitin ligase CRL2 FEM1C -mediated recognition of C-degron. Nat.Chem.Biol., 17, 2021
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6UYG
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![BU of 6uyg by Molmil](/molmil-images/mine/6uyg) | Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3A and non neutralizing antibody E1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | Authors: | Tzarum, N, Wilson, I.A, Zhu, J. | Deposit date: | 2019-11-13 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.375 Å) | Cite: | Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
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7Y3A
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![BU of 7y3a by Molmil](/molmil-images/mine/7y3a) | Crystal structure of TRIM7 bound to 2C | Descriptor: | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-2C | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y3B
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![BU of 7y3b by Molmil](/molmil-images/mine/7y3b) | Crystal structure of TRIM7 bound to GN1 | Descriptor: | E3 ubiquitin-protein ligase TRIM7,TRIM7-GN1 | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y3C
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![BU of 7y3c by Molmil](/molmil-images/mine/7y3c) | Crystal structure of TRIM7 bound to RACO-1 | Descriptor: | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-RACO-1 | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
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6VIZ
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![BU of 6viz by Molmil](/molmil-images/mine/6viz) | BRD4_Bromodomain1 complex with pyrrolopyridone compound 27 | Descriptor: | 4-[2-(2,6-dimethylphenoxy)-5-(ethylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Longenecker, K.L, Park, C.H, Qiu, W. | Deposit date: | 2020-01-14 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.391 Å) | Cite: | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
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5G0C
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![BU of 5g0c by Molmil](/molmil-images/mine/5g0c) | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C | Descriptor: | CARBONIC ANHYDRASE 2, ETHANOL, SODIUM ION, ... | Authors: | Mujumdar, P, Supuran, C.T, Peat, T.S, Poulsen, S.A. | Deposit date: | 2016-03-17 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition and Protein X-Ray Structures of Psammaplin C. J.Med.Chem., 59, 2016
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5TZF
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![BU of 5tzf by Molmil](/molmil-images/mine/5tzf) | Structure of the BldD CTD(D116A)-(c-di-GMP)2 intermediate, form 1 | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | Authors: | Schumacher, M.A. | Deposit date: | 2016-11-21 | Release date: | 2017-04-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res., 45, 2017
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5GSK
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![BU of 5gsk by Molmil](/molmil-images/mine/5gsk) | Crystal structure of duplex DNA3 in complex with Hg(II) and Sr(II) | Descriptor: | DNA (5'-D(*GP*GP*TP*CP*GP*TP*CP*C)-3'), MERCURY (II) ION, STRONTIUM ION | Authors: | Liu, H.H, Wang, R, Yao, Q.Q, Cheng, Y.Q, Yang, C, Luo, Q, Wu, B.X, Li, J.X, Ma, J.B, Sheng, J, Gan, J.H. | Deposit date: | 2016-08-16 | Release date: | 2017-02-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex Nucleic Acids Res., 45, 2017
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5TRG
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![BU of 5trg by Molmil](/molmil-images/mine/5trg) | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2 | Descriptor: | N,N-diethyl-N~2~-[(2E)-3-phenylprop-2-enoyl]-L-asparaginyl-4-fluoro-N-[(naphthalen-1-yl)methyl]-L-phenylalaninamide, Proteasome subunit alpha, Proteasome subunit beta | Authors: | Hsu, H.-C, Fan, H, Singh, R.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | Deposit date: | 2016-10-26 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.804 Å) | Cite: | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry, 56, 2017
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