7D9N
Crystal structure of a non-canonic progeria mutation S143F at lamin A/C and its structural implication to the premature aging
Summary for 7D9N
Entry DOI | 10.2210/pdb7d9n/pdb |
Descriptor | Lamin-A/C (1 entity in total) |
Functional Keywords | nuclear lamin a/c, lamin s143f, intermediate filament, hgps, structural protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 47331.01 |
Authors | |
Primary citation | Ahn, J.,Jeong, S.,Kang, S.M.,Jo, I.,Park, B.J.,Ha, N.C. Crystal structure of progeria mutant S143F lamin A/C reveals increased hydrophobicity driving nuclear deformation. Commun Biol, 5:267-267, 2022 Cited by PubMed: 35338226DOI: 10.1038/s42003-022-03212-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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