7D9N
Crystal structure of a non-canonic progeria mutation S143F at lamin A/C and its structural implication to the premature aging
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lamin-A/C | polymer | 204 | 23665.5 | 2 | UniProt (P02545) Pfam (PF00038) | Homo sapiens (Human) | 70 kDa lamin,Renal carcinoma antigen NY-REN-32 |
Sequence modifications
A, B: 27 - 229 (UniProt: P02545)
| PDB | External Database | Details |
|---|---|---|
| Phe 143 | Ser 143 | engineered mutation |
| Ala 230 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47331.0 | |
| All* | Total formula weight | 47331.0 |
