4UJ2
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![BU of 4uj2 by Molmil](/molmil-images/mine/4uj2) | Protein Kinase A in complex with an Inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-iodanylphenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... | Authors: | Alam, K.A, Engh, R.A. | Deposit date: | 2015-04-07 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.019 Å) | Cite: | Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
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4UJB
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![BU of 4ujb by Molmil](/molmil-images/mine/4ujb) | Protein Kinase A in complex with an Inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-fluorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... | Authors: | Alam, K.A, Engh, R.A. | Deposit date: | 2015-04-09 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
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4UJ9
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![BU of 4uj9 by Molmil](/molmil-images/mine/4uj9) | Protein Kinase A in complex with an Inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-[4-(trifluoromethyl)phenyl]carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, cAMP-dependent protein kinase catalytic subunit alpha, ... | Authors: | Alam, K.A, Engh, R.A. | Deposit date: | 2015-04-09 | Release date: | 2016-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
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4UJ1
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![BU of 4uj1 by Molmil](/molmil-images/mine/4uj1) | Protein Kinase A in complex with an Inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... | Authors: | Alam, K.A, Engh, R.A. | Deposit date: | 2015-04-07 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.768 Å) | Cite: | Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
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4V6C
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![BU of 4v6c by Molmil](/molmil-images/mine/4v6c) | Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhang, W, Dunkle, J.A, Cate, J.H.D. | Deposit date: | 2009-06-27 | Release date: | 2014-07-09 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structures of the ribosome in intermediate States of ratcheting. Science, 325, 2009
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4V7V
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![BU of 4v7v by Molmil](/molmil-images/mine/4v7v) | Crystal structure of the E. coli ribosome bound to clindamycin. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D. | Deposit date: | 2010-08-16 | Release date: | 2014-07-09 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (3.2891 Å) | Cite: | Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc.Natl.Acad.Sci.USA, 107, 2010
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1WLN
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![BU of 1wln by Molmil](/molmil-images/mine/1wln) | |
4V9D
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![BU of 4v9d by Molmil](/molmil-images/mine/4v9d) | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Dunkle, J.A, Wang, L, Feldman, M.B, Pulk, A, Chen, V.B, Kapral, G.J, Noeske, J, Richardson, J.S, Blanchard, S.C, Cate, J.H.D. | Deposit date: | 2012-07-31 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science, 332, 2011
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4WBB
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![BU of 4wbb by Molmil](/molmil-images/mine/4wbb) | Single Turnover Autophosphorylation Cycle of the PKA RIIb Holoenzyme | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... | Authors: | Zhang, P, Knape, M.J, Ahuja, L.G, Keshwani, M.M, King, C.C, Sastri, M, Herberg, F.W, Taylor, S.S. | Deposit date: | 2014-09-02 | Release date: | 2015-05-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme. Plos Biol., 13, 2015
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1WXA
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![BU of 1wxa by Molmil](/molmil-images/mine/1wxa) | Solution Structure of Ras-binding Domain in Mouse AF-6 Protein | Descriptor: | Afadin | Authors: | Zhao, C, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-01-20 | Release date: | 2005-07-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of Ras-binding Domain in Mouse AF-6 Protein To be Published
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4WB7
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![BU of 4wb7 by Molmil](/molmil-images/mine/4wb7) | Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A (catalytic alpha subunit) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, PKI (5-24), ... | Authors: | Cheung, J, Ginter, C, Cassidy, M, Franklin, M.C, Rudolph, M.J, Hendrickson, W.A. | Deposit date: | 2014-09-02 | Release date: | 2015-01-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112, 2015
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2M8K
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![BU of 2m8k by Molmil](/molmil-images/mine/2m8k) | A pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo | Descriptor: | RNA (48-MER) | Authors: | Cash, D.D, Cohen, O, Kim, N, Shefer, K, Brown, Y, Ulyanov, N.B, Tzfati, Y, Feigon, J. | Deposit date: | 2013-05-22 | Release date: | 2013-06-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo. Proc.Natl.Acad.Sci.USA, 110, 2013
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4WB8
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![BU of 4wb8 by Molmil](/molmil-images/mine/4wb8) | Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit), exon 1 deletion | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Cheung, J, Ginter, C, Cassidy, M, Franklin, M.C, Rudolph, M.J, Hendrickson, W.A. | Deposit date: | 2014-09-02 | Release date: | 2015-01-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112, 2015
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4V6E
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![BU of 4v6e by Molmil](/molmil-images/mine/4v6e) | Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhang, W, Dunkle, J.A, Cate, J.H.D. | Deposit date: | 2009-06-28 | Release date: | 2014-07-09 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (3.712 Å) | Cite: | Structures of the ribosome in intermediate States of ratcheting. Science, 325, 2009
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4V7T
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![BU of 4v7t by Molmil](/molmil-images/mine/4v7t) | Crystal structure of the E. coli ribosome bound to chloramphenicol. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D. | Deposit date: | 2010-08-14 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1942 Å) | Cite: | Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WMO
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![BU of 2wmo by Molmil](/molmil-images/mine/2wmo) | Structure of the complex between DOCK9 and Cdc42. | Descriptor: | CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Yang, J, Roe, S.M, Barford, D. | Deposit date: | 2009-07-02 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor. Science, 325, 2009
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2MD6
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![BU of 2md6 by Molmil](/molmil-images/mine/2md6) | NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis | Descriptor: | ALPHA CONOTOXIN LO1A | Authors: | Maiti, M, Lescrinier, E, Herdewijn, P, Lebbe, E.K.M, Peigneur, S, D'Souza, L, Tytgat, J. | Deposit date: | 2013-09-01 | Release date: | 2014-03-05 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure-Function Elucidation of a New alpha-Conotoxin, Lo1a, from Conus longurionis. J.Biol.Chem., 289, 2014
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6I14
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![BU of 6i14 by Molmil](/molmil-images/mine/6i14) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 9 | Descriptor: | 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide, ACETATE ION, Fascin | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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8DR7
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![BU of 8dr7 by Molmil](/molmil-images/mine/8dr7) | Open state of RFC:PCNA bound to a nicked dsDNA | Descriptor: | DNA (26-MER), DNA (5'-D(P*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... | Authors: | Schrecker, M, Hite, R.K. | Deposit date: | 2022-07-20 | Release date: | 2022-08-17 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
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6WBG
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![BU of 6wbg by Molmil](/molmil-images/mine/6wbg) | Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7 | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Lu, W, Du, J, Ruan, Z. | Deposit date: | 2020-03-26 | Release date: | 2020-06-03 | Last modified: | 2021-06-30 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature, 584, 2020
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6WBI
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![BU of 6wbi by Molmil](/molmil-images/mine/6wbi) | |
6WBF
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![BU of 6wbf by Molmil](/molmil-images/mine/6wbf) | Cryo-EM structure of wild type human Pannexin 1 channel | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Lu, W, Du, J, Ruan, Z. | Deposit date: | 2020-03-26 | Release date: | 2020-06-03 | Last modified: | 2021-06-30 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature, 584, 2020
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3JZ7
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![BU of 3jz7 by Molmil](/molmil-images/mine/3jz7) | |
2WMN
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![BU of 2wmn by Molmil](/molmil-images/mine/2wmn) | Structure of the complex between DOCK9 and Cdc42-GDP. | Descriptor: | CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-DIPHOSPHATE | Authors: | Yang, J, Roe, S.M, Barford, D. | Deposit date: | 2009-07-02 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.391 Å) | Cite: | Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor. Science, 325, 2009
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6I15
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![BU of 6i15 by Molmil](/molmil-images/mine/6i15) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 11 | Descriptor: | 1,2-ETHANEDIOL, 1-[[2,2-bis(fluoranyl)-1,3-benzodioxol-5-yl]methyl]-~{N}-methyl-2-oxidanylidene-pyridine-3-carboxamide, ACETATE ION, ... | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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