4UJ9

Protein Kinase A in complex with an Inhibitor

Summary for 4UJ9

• Entry DOI: 10.2210/pdb4uj9/pdb
• Related: 4UJ1 4UJ2 4UJA 4UJB
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 7-[(3S,4R)-4-[4-(trifluoromethyl)phenyl]carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, ... (5 entities in total)
• Functional Keywords: transferase, pka
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 43658.68

Authors

Alam, K.A.,Engh, R.A. (deposition date: 2015-04-09, release date: 2016-04-13, Last modification date: 2024-01-31)

• Primary citation: Lauber, B.S.,Hardegger, L.A.,Asraful, A.K.,Lund, B.A.,Dumele, O.,Harder, M.,Kuhn, B.,Engh, R.A.,Diederich, F.; Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic.; Chemistry, 22:211-, 2016; PubMed: 26578105; DOI: 10.1002/CHEM.201503552

Experimental method

X-RAY DIFFRACTION (1.87 Å)