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8C8W
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BU of 8c8w by Molmil
Priestia megaterium mupirocin hyper-resistant HIGH motif mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue
Descriptor: D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ...
Authors:Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I.
Deposit date:2023-01-21
Release date:2023-08-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif.
Nat Commun, 14, 2023
8C9G
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BU of 8c9g by Molmil
Priestia megaterium mupirocin-sensitive isoleucyl-tRNA synthetase 1 complexed with mupirocin
Descriptor: CHLORIDE ION, GLYCEROL, Isoleucine--tRNA ligase, ...
Authors:Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I.
Deposit date:2023-01-22
Release date:2023-08-23
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif.
Nat Commun, 14, 2023
8C9E
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BU of 8c9e by Molmil
Priestia megaterium mupirocin-sensitive isoleucyl-tRNA synthetase 1 complexed with an isoleucyl-adenylate analogue
Descriptor: CHLORIDE ION, Isoleucine--tRNA ligase, LITHIUM ION, ...
Authors:Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I.
Deposit date:2023-01-21
Release date:2023-08-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif.
Nat Commun, 14, 2023
1QVG
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BU of 1qvg by Molmil
Structure of CCA oligonucleotide bound to the tRNA binding sites of the large ribosomal subunit of Haloarcula marismortui
Descriptor: 23S ribosomal rna, 50S RIBOSOMAL PROTEIN L10E, 50S ribosomal protein L13P, ...
Authors:Schmeing, T.M, Moore, P.B, Steitz, T.A.
Deposit date:2003-08-27
Release date:2003-11-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit
RNA, 9, 2003
1QVF
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BU of 1qvf by Molmil
Structure of a deacylated tRNA minihelix bound to the E site of the large ribosomal subunit of Haloarcula marismortui
Descriptor: 23S ribosomal rna, 50S RIBOSOMAL PROTEIN L10E, 50S ribosomal protein L13P, ...
Authors:Schmeing, T.M, Moore, P.B, Steitz, T.A.
Deposit date:2003-08-27
Release date:2003-11-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit
RNA, 9, 2003
6IA2
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BU of 6ia2 by Molmil
Crystal structure of a self-complementary RNA duplex recognized by Com
Descriptor: CHLORIDE ION, RNA (5'-R(*AP*GP*AP*GP*AP*AP*CP*CP*CP*GP*GP*AP*GP*UP*UP*CP*CP*CP*U)-3'), SULFATE ION
Authors:Nowacka, M, Fernandes, H, Kiliszek, A, Bernat, A, Lach, G, Bujnicki, J.M.
Deposit date:2018-11-26
Release date:2019-03-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Specific interaction of zinc finger protein Com with RNA and the crystal structure of a self-complementary RNA duplex recognized by Com.
Plos One, 14, 2019
6V4X
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BU of 6v4x by Molmil
Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom resolution
Descriptor: Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor subunit 3, Small nuclear ribonucleoprotein E, ...
Authors:Sun, Y, Zhang, Y, Walz, T, Tong, L.
Deposit date:2019-12-02
Release date:2020-02-19
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of an active human histone pre-mRNA 3'-end processing machinery.
Science, 367, 2020
6O76
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BU of 6o76 by Molmil
Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain
Descriptor: CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic
Authors:Kuhle, B, Yang, X.L.
Deposit date:2019-03-07
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.787 Å)
Cite:CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 116, 2019
7UZ0
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AntiT-tRNA flip UCCA
Descriptor: AntiT-tRNA flip UCCA, MAGNESIUM ION, STRONTIUM ION
Authors:Price, I.R, Grigg, J.C, Ke, A.
Deposit date:2022-05-07
Release date:2022-06-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:tRNA Fusion to Streamline RNA Structure Determination: Case Studies in Probing Aminoacyl-tRNA Sensing Mechanisms by the T-Box Riboswitch
Crystals, 12, 2022
9DRV
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BU of 9drv by Molmil
Crystal structure of M. tuberculosis PheRS-tRNA complex bound to inhibitor D-004
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ...
Authors:Gade, P, Chang, C, Forte, B, Wower, J, Gilbert, I.H, Baragana, B, Michalska, K, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2024-09-26
Release date:2025-02-12
Last modified:2025-02-19
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase.
Eur.J.Med.Chem., 287, 2025
5J61
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BU of 5j61 by Molmil
D-aminoacyl-tRNA deacylase (DTD) from Plasmodium falciparum in complex with glycyl-3'-aminoadenosine at 2.10 Angstrom resolution
Descriptor: 3'-deoxy-3'-(glycylamino)adenosine, D-tyrosyl-tRNA(Tyr) deacylase
Authors:Routh, S.B, Ahmad, S, Sankaranarayanan, R.
Deposit date:2016-04-04
Release date:2016-09-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase
Plos Biol., 14, 2016
5XIP
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BU of 5xip by Molmil
Crystal Structure of Eimeria tenella Prolyl-tRNA Synthetase (EtPRS) in complex with Halofuginone
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIK
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BU of 5xik by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with tetrahydro quinazolinone febrifugine
Descriptor: 3-[2-oxidanylidene-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]-5,6,7,8-tetrahydroquinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIJ
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BU of 5xij by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9
Descriptor: 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIH
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BU of 5xih by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 5
Descriptor: 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
8C9F
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BU of 8c9f by Molmil
Priestia megaterium inactive HIGH motif mutant of type1 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue.
Descriptor: CHLORIDE ION, Isoleucine--tRNA ligase, LITHIUM ION, ...
Authors:Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I.
Deposit date:2023-01-21
Release date:2023-08-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif.
Nat Commun, 14, 2023
6UGJ
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BU of 6ugj by Molmil
Crystal structure of a fragment of E. coli tRNA(Asp) consisting of its acceptor stem/T stem-loop. Short unit cell.
Descriptor: DIPHOSPHATE, SULFATE ION, URACIL, ...
Authors:Chan, C.W, Mondragon, A.
Deposit date:2019-09-26
Release date:2020-01-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs.
Rna, 26, 2020
6UGI
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BU of 6ugi by Molmil
Crystal structure of a fragment of E. coli tRNA(Asp) consisting of its acceptor stem/T stem-loop. Long unit cell.
Descriptor: SULFATE ION, tRNA(Asp) acceptor stem/T stem-loop
Authors:Chan, C.W, Mondragon, A.
Deposit date:2019-09-26
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs.
Rna, 26, 2020
8WND
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BU of 8wnd by Molmil
Crystal structure of Saccharomyces cerevisiae isoleucyl-tRNA synthetase in complex with tRNA(Ile) and isoleucine
Descriptor: 1,2-ETHANEDIOL, ISOLEUCINE, SULFATE ION, ...
Authors:Chen, B, Yi, F, Zhou, H.
Deposit date:2023-10-05
Release date:2024-10-09
Last modified:2025-01-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The mechanism of discriminative aminoacylation by isoleucyl-tRNA synthetase based on wobble nucleotide recognition.
Nat Commun, 15, 2024
7K16
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BU of 7k16 by Molmil
Tamana Bat Virus xrRNA1
Descriptor: MAGNESIUM ION, RNA (51-MER), SODIUM ION
Authors:Jones, R.A, Kieft, J.S.
Deposit date:2020-09-07
Release date:2020-10-14
Last modified:2025-05-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA.
Rna, 27, 2021
6U9X
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BU of 6u9x by Molmil
Structure of T. brucei MERS1-RNA complex
Descriptor: Mitochondrial edited mRNA stability factor 1, RNA (5'-R(*GP*AP*GP*AP*GP*GP*GP*GP*GP*UP*U)-3')
Authors:Schumacher, M.A.
Deposit date:2019-09-09
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei.
Rna, 26, 2020
6Y3G
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BU of 6y3g by Molmil
Crystal structure of phenylalanine tRNA from Escherichia coli
Descriptor: CALCIUM ION, GLYCEROL, GUANIDINE, ...
Authors:Bourgeois, G, Mechulam, Y, Schmitt, E.
Deposit date:2020-02-18
Release date:2020-12-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of the interaction between cyclodipeptide synthases and aminoacylated tRNA substrates.
Rna, 26, 2020
3A6P
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BU of 3a6p by Molmil
Crystal structure of Exportin-5:RanGTP:pre-miRNA complex
Descriptor: 13-mer peptide, Exportin-5, GTP-binding nuclear protein Ran, ...
Authors:Okada, C, Yamashita, E, Lee, S.J, Shibata, S, Katahira, J, Nakagawa, A, Yoneda, Y, Tsukihara, T.
Deposit date:2009-09-07
Release date:2009-12-08
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:A high-resolution structure of the pre-microRNA nuclear export machinery
Science, 326, 2009
1GTS
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BU of 1gts by Molmil
STRUCTURAL BASIS FOR TRANSFER RNA AMINOACEYLATION BY ESCHERICHIA COLI GLUTAMINYL-TRNA SYNTHETASE
Descriptor: ADENOSINE MONOPHOSPHATE, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE (E.C.6.1.1.18)), TRNAGLN
Authors:Perona, J.J, Steitz, T.A, Rould, M.A.
Deposit date:1993-09-15
Release date:1995-02-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.
Biochemistry, 32, 1993
5OMW
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BU of 5omw by Molmil
Mutant T252A of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the aminoacylation conformation
Descriptor: 5'-O-(L-leucylsulfamoyl)adenosine, L-leucyl-tRNA, Leucine--tRNA ligase, ...
Authors:Palencia, A, Cusack, S.
Deposit date:2017-08-02
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018

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