8C9F

Priestia megaterium inactive HIGH motif mutant of type1 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue.

Summary for 8C9F

Entry DOI	10.2210/pdb8c9f/pdb
Descriptor	Isoleucine--tRNA ligase, ZINC ION, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ... (7 entities in total)
Functional Keywords	antibiotic, mupirocin-sensitive, ilers1, rna binding protein
Biological source	Priestia megaterium
Total number of polymer chains	1
Total formula weight	106993.21
Authors	Brkic, A.,Leibundgut, M.,Jablonska, J.,Zanki, V.,Car, Z.,Petrovic Perokovic, V.,Ban, N.,Gruic-Sovulj, I. (deposition date: 2023-01-21, release date: 2023-08-16, Last modification date: 2024-03-27)
Primary citation	Brkic, A.,Leibundgut, M.,Jablonska, J.,Zanki, V.,Car, Z.,Petrovic Perokovic, V.,Marsavelski, A.,Ban, N.,Gruic-Sovulj, I. Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14:5498-5498, 2023 Cited by PubMed: 37679387 DOI: 10.1038/s41467-023-41244-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation