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3D08	Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Suad, O, Rozenberg, H, Shimon, L.J.W, Frolow, F, Shakked, Z. Deposit date: 2008-05-01 Release date: 2009-01-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
3D09	Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Rozenberg, H, Suad, O, Shakked, Z. Deposit date: 2008-05-01 Release date: 2009-01-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
3D0A	Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA Descriptor: Cellular tumor antigen p53, DNA (5'-D(*DCP*DGP*DGP*DGP*DCP*DAP*DTP*DGP*DCP*DCP*DCP*DG)-3'), ZINC ION Authors: Suad, O, Rozenberg, H, Shakked, Z. Deposit date: 2008-05-01 Release date: 2009-01-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
3D06	Human p53 core domain with hot spot mutation R249S (I) Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Rozenberg, H, Suad, O, Shimon, L.J.W, Frolow, F, Shakked, Z. Deposit date: 2008-05-01 Release date: 2009-01-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
3D07	Human p53 core domain with hot spot mutation R249S (III) Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Suad, O, Rozenberg, H, Shakked, Z. Deposit date: 2008-05-01 Release date: 2009-01-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
3D05	Human p53 core domain with hot spot mutation R249S (II) Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Suad, O, Rozenberg, H, Shimon, L.J.W, Frolow, F, Shakked, Z. Deposit date: 2008-05-01 Release date: 2009-01-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
2RUK	Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain Descriptor: Cellular tumor antigen p53, General transcription factor IIH subunit 1 Authors: Okuda, M, Nishimura, Y. Deposit date: 2014-09-24 Release date: 2014-10-15 Last modified: 2022-08-24 Method: SOLUTION NMR Cite: Extended string binding mode of the phosphorylated transactivation domain of tumor suppressor p53. J.Am.Chem.Soc., 136, 2014
4RP7	Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258) Descriptor: TIITLE hexapeptide segment from p53, ZINC ION Authors: Soriaga, A.B, Soragni, A, Eisenberg, D. Deposit date: 2014-10-29 Release date: 2016-01-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.576 Å) Cite: A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell, 29, 2016
4RP6	Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258) Descriptor: LTIITLE heptapeptide segment from p53 Authors: Soriaga, A.B, Soragni, A, Eisenberg, D. Deposit date: 2014-10-29 Release date: 2016-01-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.703 Å) Cite: A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell, 29, 2016
4IRV	Structure of the Helicobacter pylori CagA Oncogene Bound to the Human Tumor Suppressor Apoptosis-stimulating Protein of p53-2 Descriptor: Apoptosis-stimulating of p53 protein 2, Cytotoxicity-associated immunodominant antigen Authors: Stebbins, C.E, Nesic, D. Deposit date: 2013-01-15 Release date: 2014-01-15 Last modified: 2015-02-25 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2. Proc.Natl.Acad.Sci.USA, 111, 2014
3TS8	Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element Descriptor: CDKN1A(p21) anti-sense strand, CDKN1A(p21) sense strand, Cellular tumor antigen p53, ... Authors: Halazonetis, T.D, Emamzadah, S. Deposit date: 2011-09-12 Release date: 2011-11-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element. Mol Cancer Res, 9, 2011
2MZD	Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex Descriptor: Cellular tumor antigen p53, Histone acetyltransferase p300 Authors: Miller Jenkins, L.M, Feng, H, Durell, S.R, Tagad, H.D, Mazur, S.J, Tropea, J.E, Bai, Y, Appella, E. Deposit date: 2015-02-11 Release date: 2015-03-25 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex. Biochemistry, 54, 2015
4MZI	Crystal structure of a human mutant p53 Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Emamzadah, S, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D. Deposit date: 2013-09-30 Release date: 2014-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. J.Mol.Biol., 426, 2014
4MZR	Crystal structure of a polypeptide p53 mutant bound to DNA Descriptor: Cellular tumor antigen p53, ZINC ION, consensus DNA anti-sense strand, ... Authors: Emamzadah, S.T, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D. Deposit date: 2013-09-30 Release date: 2014-01-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. J.Mol.Biol., 426, 2014
6FF9	Mutant R280K of human P53 Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Trovao, F.G, Gomes, A.S, Pinheiro, B, Carvalho, A.L, Romao, M.J. Deposit date: 2018-01-04 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding. Int J Mol Sci, 19, 2018
5O1D	p53 cancer mutant Y220C in complex with compound MB481 Descriptor: 3-iodanyl-2-oxidanyl-5-propoxy-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... Authors: Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1C	p53 cancer mutant Y220C in complex with compound MB184 Descriptor: 5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, ZINC ION Authors: Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1I	p53 cancer mutant Y220C in complex with compound MB710 Descriptor: 1,2-ETHANEDIOL, 2-(diethylamino)-6-iodanyl-5-oxidanyl-7-pyrrol-1-yl-1,3-benzothiazole-4-carboxylic acid, Cellular tumor antigen p53, ... Authors: Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1F	p53 cancer mutant Y220C in complex with compound MB582 Descriptor: 5-butoxy-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, ZINC ION Authors: Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1E	p53 cancer mutant Y220C im complex with compound MB577 Descriptor: 3-iodanyl-2-oxidanyl-5-prop-2-enoxy-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... Authors: Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1A	p53 cancer mutant Y220C in complex with compound MB240 Descriptor: Cellular tumor antigen p53, GLYCEROL, ZINC ION, ... Authors: Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1H	p53 cancer mutant Y220C in complex with compound MB539 Descriptor: 3-iodanyl-2-oxidanyl-5-propylsulfanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... Authors: Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1G	p53 cancer mutant Y220C in complex with compound MB487 Descriptor: 3-iodanyl-2-oxidanyl-5-(2-phenylethoxy)-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... Authors: Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
5O1B	p53 cancer mutant Y220C in complex with compound MB84 Descriptor: 6-(hydroxymethyl)-2,4-bis(iodanyl)-3-pyrrol-1-yl-phenol, Cellular tumor antigen p53, GLYCEROL, ... Authors: Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. Deposit date: 2017-05-18 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
1HS5	NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER Descriptor: CELLULAR TUMOR ANTIGEN P53 Authors: Davison, T.S, Nie, X, Ma, W, Li, Y, Kay, C, Benchimol, S, Arrowsmith, C.H. Deposit date: 2000-12-22 Release date: 2001-01-10 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure and functionality of a designed p53 dimer. J.Mol.Biol., 307, 2001

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