5O1C

p53 cancer mutant Y220C in complex with compound MB184

Summary for 5O1C

DescriptorCellular tumor antigen p53, ZINC ION, 5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, ... (4 entities in total)
Functional Keywordsp53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, dna binding protein, molecular chaperones
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Total number of polymer chains2
Total molecular weight50038.79
Authors
Joerger, A.C.,Baud, M.G.J.,Bauer, M.R.,Fersht, A.R. (deposition date: 2017-05-18, release date: 2018-05-09)
Primary citation
Baud, M.G.J.,Bauer, M.R.,Verduci, L.,Dingler, F.A.,Patel, K.J.,Horil Roy, D.,Joerger, A.C.,Fersht, A.R.
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152:101-114, 2018
PubMed: 29702446 (PDB entries with the same primary citation)
DOI: 10.1016/j.ejmech.2018.04.035
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.32 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.153200.6%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-07-29