4RP6

Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258)

Summary for 4RP6

Related4RP7
DescriptorLTIITLE heptapeptide segment from p53 (2 entities in total)
Functional Keywordsp53, amyloid, fibril, amyloid-like protofibril, p53 aggregates, polymer, transcription factor, oncogene, cancer, p53 mutant, protein fibril
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Total number of polymer chains1
Total molecular weight801.97
Authors
Soriaga, A.B.,Soragni, A.,Eisenberg, D. (deposition date: 2014-10-29, release date: 2016-01-13, Last modification date: 2016-01-27)
Primary citation
Soragni, A.,Janzen, D.M.,Johnson, L.M.,Lindgren, A.G.,Thai-Quynh Nguyen, A.,Tiourin, E.,Soriaga, A.B.,Lu, J.,Jiang, L.,Faull, K.F.,Pellegrini, M.,Memarzadeh, S.,Eisenberg, D.S.
A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Cancer Cell, 29:90-103, 2016
PubMed: 26748848 (PDB entries with the same primary citation)
DOI: 10.1016/j.ccell.2015.12.002
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.703 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2030000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4rp6
no rotation
Molmil generated image of 4rp6
rotated about x axis by 90°
Molmil generated image of 4rp6
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 4rp6
no rotation
Molmil generated image of 4rp6
rotated about x axis by 90°
Molmil generated image of 4rp6
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4rp6.pdb1.gz [5.83 KB])