4HHJ
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![BU of 4hhj by Molmil](/molmil-images/mine/4hhj) | Dengue serotype 3 RNA-dependent RNA polymerase | Descriptor: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ... | Authors: | Noble, C.G, Lescar, J. | Deposit date: | 2012-10-10 | Release date: | 2013-02-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013
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2HFZ
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![BU of 2hfz by Molmil](/molmil-images/mine/2hfz) | |
4HDG
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![BU of 4hdg by Molmil](/molmil-images/mine/4hdg) | Crystal Structure of viral RdRp in complex with GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION | Authors: | Surana, P, Nair, D.T. | Deposit date: | 2012-10-02 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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5IQ6
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![BU of 5iq6 by Molmil](/molmil-images/mine/5iq6) | Crystal structure of Dengue virus serotype 3 RNA dependent RNA polymerase bound to HeE1-2Tyr, a new pyridobenzothizole inhibitor | Descriptor: | N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine, RNA dependent RNA polymerase, ZINC ION | Authors: | Tarantino, D, Mastrangelo, E, Milani, M. | Deposit date: | 2016-03-10 | Release date: | 2016-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res., 134, 2016
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5U04
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![BU of 5u04 by Molmil](/molmil-images/mine/5u04) | Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase | Descriptor: | PHOSPHATE ION, ZINC ION, Zika Virus NS5 RdRp | Authors: | Godoy, A.S, Lima, G.M.A, Oliveira, K.I.Z, Torres, N.U, Maluf, F.V, Guido, R.V.C, Oliva, G. | Deposit date: | 2016-11-22 | Release date: | 2017-02-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase. Nat Commun, 8, 2017
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5K5M
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![BU of 5k5m by Molmil](/molmil-images/mine/5k5m) | |
5JJS
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![BU of 5jjs by Molmil](/molmil-images/mine/5jjs) | Dengue 3 NS5 protein with compound 27 | Descriptor: | 1,2-ETHANEDIOL, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-{[(1R,3R)-3-methoxycyclohexyl]sulfonyl}benzamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lescar, J, El Sahili, A. | Deposit date: | 2016-04-25 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
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5I3Q
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![BU of 5i3q by Molmil](/molmil-images/mine/5i3q) | DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29 | Descriptor: | 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide, Genome polyprotein, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2016-02-10 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
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5TFR
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![BU of 5tfr by Molmil](/molmil-images/mine/5tfr) | Crystal structure of Zika Virus NS5 protein | Descriptor: | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Longenecker, K.L, Upadhyay, A.K. | Deposit date: | 2016-09-26 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5. Acta Crystallogr F Struct Biol Commun, 73, 2017
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5JJR
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![BU of 5jjr by Molmil](/molmil-images/mine/5jjr) | Dengue 3 NS5 protein with compound 29 | Descriptor: | 1,2-ETHANEDIOL, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lescar, J, El Sahili, A. | Deposit date: | 2016-04-25 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
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5TMH
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![BU of 5tmh by Molmil](/molmil-images/mine/5tmh) | Structure of Zika virus NS5 | Descriptor: | GLYCEROL, Polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Wang, B, Tan, X, Song, J. | Deposit date: | 2016-10-12 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.278 Å) | Cite: | The structure of Zika virus NS5 reveals a conserved domain conformation. Nat Commun, 8, 2017
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5U0C
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![BU of 5u0c by Molmil](/molmil-images/mine/5u0c) | |
5U0B
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![BU of 5u0b by Molmil](/molmil-images/mine/5u0b) | Structure of full-length Zika virus NS5 | Descriptor: | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Zhao, B, Du, F. | Deposit date: | 2016-11-23 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure and function of the Zika virus full-length NS5 protein. Nat Commun, 8, 2017
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8WIL
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![BU of 8wil by Molmil](/molmil-images/mine/8wil) | Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D55 construct) | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... | Authors: | Wang, X, Jing, X, Deng, F, Gong, P. | Deposit date: | 2023-09-24 | Release date: | 2024-01-17 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
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8WIM
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![BU of 8wim by Molmil](/molmil-images/mine/8wim) | Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D307 construct) | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... | Authors: | Wang, X, Jing, X, Deng, F, Gong, P. | Deposit date: | 2023-09-24 | Release date: | 2024-01-17 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
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8WU2
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![BU of 8wu2 by Molmil](/molmil-images/mine/8wu2) | Crystal structure of RNA-dependent RNA polymerases from Jingmen tick virus | Descriptor: | RNA polymerase, SELENIUM ATOM | Authors: | Liu, Z, Han, P, Peng, Q, Qi, J. | Deposit date: | 2023-10-20 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus HLIFE, 2, 2024
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8WU3
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![BU of 8wu3 by Molmil](/molmil-images/mine/8wu3) | |
6H80
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![BU of 6h80 by Molmil](/molmil-images/mine/6h80) | Dengue-RdRp3-inhibitor complex co-crystallisation | Descriptor: | 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2018-07-31 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
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6KR2
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![BU of 6kr2 by Molmil](/molmil-images/mine/6kr2) | Crystal structure of Dengue virus nonstructural protein NS5 (form 1) | Descriptor: | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Wu, J, Lu, G, Ye, H.Q, Gong, P. | Deposit date: | 2019-08-20 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathog., 16, 2020
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6KR3
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![BU of 6kr3 by Molmil](/molmil-images/mine/6kr3) | Crystal structure of Dengue virus nonstructural protein NS5 (form 2) | Descriptor: | GLYCEROL, Genome polyprotein, IODIDE ION, ... | Authors: | Wu, J, Lu, G, Ye, H.Q, Gong, P. | Deposit date: | 2019-08-20 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.931 Å) | Cite: | A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathog., 16, 2020
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6LD2
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![BU of 6ld2 by Molmil](/molmil-images/mine/6ld2) | Zika NS5 polymerase domain | Descriptor: | (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid, RNA-directed RNA polymerase NS5, ZINC ION | Authors: | El Sahili, A, Lescar, J. | Deposit date: | 2019-11-20 | Release date: | 2020-08-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6I7P
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![BU of 6i7p by Molmil](/molmil-images/mine/6i7p) | Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033) | Descriptor: | NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N. | Deposit date: | 2018-11-16 | Release date: | 2019-04-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.975 Å) | Cite: | Supramolecular arrangement of the full-length Zika virus NS5. Plos Pathog., 15, 2019
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6LD1
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![BU of 6ld1 by Molmil](/molmil-images/mine/6ld1) | Zika NS5 polymerase domain | Descriptor: | 1,2-ETHANEDIOL, RNA-directed RNA polymerase NS5, ZINC ION | Authors: | El Sahili, A, Lescar, J. | Deposit date: | 2019-11-20 | Release date: | 2020-08-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6LD5
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![BU of 6ld5 by Molmil](/molmil-images/mine/6ld5) | Zika NS5 polymerase domain | Descriptor: | 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... | Authors: | El Sahili, A, Lescar, J. | Deposit date: | 2019-11-20 | Release date: | 2020-08-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6LD3
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![BU of 6ld3 by Molmil](/molmil-images/mine/6ld3) | Zika NS5 polymerase domain | Descriptor: | 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... | Authors: | El Sahili, A, Lescar, J. | Deposit date: | 2019-11-20 | Release date: | 2020-08-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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