Summary for 5U04
| Entry DOI | 10.2210/pdb5u04/pdb |
| Descriptor | Zika Virus NS5 RdRp, ZINC ION, PHOSPHATE ION, ... (4 entities in total) |
| Functional Keywords | ns5, zika, virus, rna, polymerase, drug, viral protein |
| Biological source | Zika virus (strain Mr 766) (ZIKV) |
| Total number of polymer chains | 1 |
| Total formula weight | 69245.41 |
| Authors | Godoy, A.S.,Lima, G.M.A.,Oliveira, K.I.Z.,Torres, N.U.,Maluf, F.V.,Guido, R.V.C.,Oliva, G. (deposition date: 2016-11-22, release date: 2017-02-22, Last modification date: 2023-10-04) |
| Primary citation | Godoy, A.S.,Lima, G.M.,Oliveira, K.I.,Torres, N.U.,Maluf, F.V.,Guido, R.V.,Oliva, G. Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase. Nat Commun, 8:14764-14764, 2017 Cited by PubMed Abstract: The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug discovery. Here we describe the crystal structure of the recombinant ZIKV NS5 RdRp domain at 1.9 Å resolution as a platform for structure-based drug design strategy. The overall structure is similar to other flaviviral homologues. However, the priming loop target site, which is suitable for non-nucleoside polymerase inhibitor design, shows significant differences in comparison with the dengue virus structures, including a tighter pocket and a modified local charge distribution. PubMed: 28345596DOI: 10.1038/ncomms14764 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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