5U04

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

Replaces:  5TIT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS714
A	CYS730
A	CYS849
A	HOH1113

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	GLU439
A	HIS443
A	CYS448
A	CYS451

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PO4 A 1003

Chain	Residue
A	ARG739
A	THR796
A	TRP797
A	HOH1356
A	ARG731

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"30848123","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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