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6W8R	Crystal structure of metacaspase 4 C139A from Arabidopsis Descriptor: Metacaspase-4, SULFATE ION Authors: Zhu, P, Yu, X.H, Wang, C, Zhang, Q, Liu, W, McSweeney, S, Shanklin, J, Lam, E, Liu, Q. Deposit date: 2020-03-21 Release date: 2020-05-20 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.801 Å) Cite: Structural basis for Ca2+-dependent activation of a plant metacaspase. Nat Commun, 11, 2020
7USQ	Crystal Structure of Caspase-3 with Peptide Inhibitor AcDVPD-CHO Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, Peptide Inhibitor AcDVPD-CHO Authors: Fuller, J.L, Finzel, B.C. Deposit date: 2022-04-25 Release date: 2022-06-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis. Arch Pharm, 355, 2022
7USO	Crystal Structure of Caspase-3 with Peptide Inhibitor AcITVKD-CHO Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, Peptide Inhibitor AcITVKD-CHO Authors: Fuller, J.L, Finzel, B.C. Deposit date: 2022-04-25 Release date: 2022-06-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis. Arch Pharm, 355, 2022
7USP	Crystal Structure of Caspase-3 with Peptide Inhibitor AcITV(Orn)D-CHO Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, Peptide Inhibitor AcITV(Orn)D-CHO Authors: Fuller, J.L, Finzel, B.C. Deposit date: 2022-04-25 Release date: 2022-06-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis. Arch Pharm, 355, 2022
6KN1	P20/P12 of caspase-11 mutant C254A Descriptor: Caspase-4 Authors: Ding, J, Sun, Q. Deposit date: 2019-08-02 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
6KMT	P32 of caspase-11 mutant C254A Descriptor: Caspase-4 Authors: Ding, J, Sun, Q. Deposit date: 2019-08-01 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
6KMU	P22/P10 complex of caspase-11 mutant C254A Descriptor: Caspase-4 Authors: Ding, J, Sun, Q. Deposit date: 2019-08-01 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
6NS7	Crystal structure of murine caspase-11 Descriptor: Caspase-11, SULFATE ION Authors: Yang, J, Liu, Z, Xiao, T.S. Deposit date: 2019-01-24 Release date: 2020-07-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of murine caspase-11 To Be Published
6NRY	Crystal structure of human caspase-4 Descriptor: Caspase-4, GLYCEROL Authors: Yang, J, Liu, Z, Shi, W, Xiao, T.S. Deposit date: 2019-01-24 Release date: 2020-07-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.184 Å) Cite: Crystal structure of human caspase-4 To Be Published
1RE1	CRYSTAL STRUCTURE OF CASPASE-3 WITH A NICOTINIC ACID ALDEHYDE INHIBITOR Descriptor: (3S)-3-{[(5-BROMOPYRIDIN-3-YL)CARBONYL]AMINO}-4-OXOBUTANOIC ACID, Caspase-3 Authors: Becker, J.W, Rotonda, J, Soisson, S.M. Deposit date: 2003-11-06 Release date: 2004-05-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis J.Med.Chem., 47, 2004
1RHM	CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A NICOTINIC ACID ALDEHYDE INHIBITOR Descriptor: 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID, CASP-3 Authors: Becker, J.W, Rotonda, J, Soisson, S.M. Deposit date: 2003-11-14 Release date: 2004-05-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis. J.Med.Chem., 47, 2004
1RHK	Crystal structure of the complex of caspase-3 with a phenyl-propyl-ketone inhibitor Descriptor: Caspase-3, acetyl-asp-glu-val-fpr Authors: Becker, J.W, Rotonda, J, Soisson, S.M. Deposit date: 2003-11-14 Release date: 2004-05-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis. J.Med.Chem., 47, 2004
1RWK	Crystal structure of human caspase-1 in complex with 3-(2-mercapto-acetylamino)-4-oxo-pentanoic acid Descriptor: 3-(2-MERCAPTO-ACETYLAMINO)-4-OXO-PENTANOIC ACID, Interleukin-1 beta convertase Authors: Romanowski, M.J, Lam, J.W, Fahr, B.T, O'Brien, T. Deposit date: 2003-12-16 Release date: 2004-12-28 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr.,Sect.F, 61, 2005
1RHR	CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A CINNAMIC ACID METHYL ESTER INHIBITOR Descriptor: (3S)-5-[(2-CHLORO-6-FLUOROBENZYL)SULFANYL]-3-{[N-({2-ETHOXY-5-[(1E)-3-METHOXY-3-OXOPROP-1-ENYL]PHENYL}ACETYL)-D-VALYL]AMINO}-4-OXOPENTANOIC ACID, Caspase-3 Authors: Becker, J.W, Rotonda, J, Soisson, S.M. Deposit date: 2003-11-14 Release date: 2004-05-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis. J.Med.Chem., 47, 2004
1RHJ	CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A PRYAZINONE INHIBITOR Descriptor: 3-(2-{5-TERT-BUTYL-3-[(4-METHYL-FURAZAN-3-YLMETHYL)-AMINO]-2-OXO-2H-PYRAZIN-1-YL}-BUTYRYLAMINO)-5-(HEXYL-METHYL-AMINO)-4-OXO-PENTANOIC ACID ANION, Caspase-3 Authors: Becker, J.W, Rotonda, J, Soisson, S.M. Deposit date: 2003-11-14 Release date: 2004-05-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis. J.Med.Chem., 47, 2004
4ZVR	Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to DEVD inhibitor. Descriptor: Caspase-7, Peptide ACE-ASP-GLU-VAL-ASJ Authors: Hill, M.E, MacPherson, D.J, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVT	Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to VEID inhibitor. Descriptor: Caspase-7, VEID inhibitor Authors: Hardy, J.A, MacPherson, D.J, Hill, M.E. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVP	Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to DEVD inhibitor. Descriptor: Caspase-7, Peptide ACE-ASP-GLU-VAL-ASA Authors: Hill, M.E, MacPherson, D.J, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVS	Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to DEVD inhibitor. Descriptor: Caspase-7, DEVD inhibitor Authors: MacPherson, D.J, Hill, M.E, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVO	Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to VEID inhibitor. Descriptor: Caspase-7, Peptide ACE-VAL-GLU-ILE-ASJ Authors: Hill, M.E, MacPherson, D.J, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
6X8H	Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct Descriptor: Ac-DW3-KE, Caspase-8 Authors: Solania, A, Xu, J.H, Wolan, D.W. Deposit date: 2020-06-01 Release date: 2021-06-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct To Be Published
6X8J	Caspase-7 in complex with ketomethylene inhibitor reveals tetrahedral adduct Descriptor: Caspase-7, ketomethylene inhibitor Authors: Solania, A, Xu, J.H, Wolan, D.W. Deposit date: 2020-06-01 Release date: 2021-06-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.604 Å) Cite: Caspase-7 in complex with ketomethylene inhibitor reveals tetrahedral adduct To Be Published
6X8L	Caspase-7 in complex with elongated ketomethylene inhibitor Descriptor: Caspase-7, ketomethylene inhibitor Authors: Solania, A, Xu, J.H, Wolan, D.W. Deposit date: 2020-06-01 Release date: 2021-06-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Caspase-7 in complex with elongated ketomethylene inhibitor To Be Published
6X8I	Caspase-3 in complex with ketomethylene inhibitor reveals tetrahedral adduct Descriptor: Caspase-3, ketomethylene inhibitor Authors: Solania, A, Xu, J.H, Wolan, D.W. Deposit date: 2020-06-01 Release date: 2021-06-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Caspase-3 in complex with ketomethylene inhibitor reveals tetrahedral adduct To Be Published
6X8K	Caspase-3 in complex with elongated ketomethylene inhibitor Descriptor: Caspase-3, ketomethylene inhibitor Authors: Solania, A, Xu, J.H, Wolan, D.W. Deposit date: 2020-06-01 Release date: 2021-06-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Caspase-3 in complex with elongated ketomethylene inhibitor To Be Published

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