4JBV
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4IM3
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![BU of 4im3 by Molmil](/molmil-images/mine/4im3) | Structure of Tank-Binding Kinase 1 | Descriptor: | CHLORIDE ION, MERCURY (II) ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ... | Authors: | Tu, D, Eck, M.J. | Deposit date: | 2013-01-01 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.342 Å) | Cite: | Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013
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4IM2
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![BU of 4im2 by Molmil](/molmil-images/mine/4im2) | Structure of Tank-Binding Kinase 1 | Descriptor: | CHLORIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | Authors: | Tu, D, Eck, M.J. | Deposit date: | 2013-01-01 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5001 Å) | Cite: | Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013
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4IM0
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![BU of 4im0 by Molmil](/molmil-images/mine/4im0) | Structure of Tank-Binding Kinase 1 | Descriptor: | N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1 | Authors: | Tu, D, Eck, M.J. | Deposit date: | 2013-01-01 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4001 Å) | Cite: | Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013
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4JL9
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![BU of 4jl9 by Molmil](/molmil-images/mine/4jl9) | Crystal structure of mouse TBK1 bound to BX795 | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | Authors: | Li, P, Shu, C. | Deposit date: | 2013-03-12 | Release date: | 2013-06-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.0999 Å) | Cite: | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. Structure, 21, 2013
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4L44
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![BU of 4l44 by Molmil](/molmil-images/mine/4l44) | Crystal structures of human p70S6K1-T389A (form II) | Descriptor: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... | Authors: | Wang, J, Zhong, C, Ding, J. | Deposit date: | 2013-06-07 | Release date: | 2013-07-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L42
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![BU of 4l42 by Molmil](/molmil-images/mine/4l42) | Crystal structures of human p70S6K1-PIF | Descriptor: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... | Authors: | Wang, J, Zhong, C, Ding, J. | Deposit date: | 2013-06-07 | Release date: | 2013-07-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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7ACK
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![BU of 7ack by Molmil](/molmil-images/mine/7ack) | CDK2/cyclin A2 in complex with an imidazo[1,2-c]pyrimidin-5-one inhibitor | Descriptor: | 1,2-ETHANEDIOL, 8-cyclohexyl-6~{H}-imidazo[1,2-c]pyrimidin-5-one, Cyclin-A2, ... | Authors: | Skerlova, J, Pachl, P, Rezacova, P. | Deposit date: | 2020-09-11 | Release date: | 2021-03-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure. Eur.J.Med.Chem., 216, 2021
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4J7B
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![BU of 4j7b by Molmil](/molmil-images/mine/4j7b) | Crystal structure of polo-like kinase 1 | Descriptor: | 205 kDa microtubule-associated protein, Polo-like kinase | Authors: | Xu, J, Shen, C, Quan, J, Wang, T. | Deposit date: | 2013-02-13 | Release date: | 2013-07-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the inhibition of Polo-like kinase 1 Nat.Struct.Mol.Biol., 20, 2013
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4L46
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![BU of 4l46 by Molmil](/molmil-images/mine/4l46) | Crystal structures of human p70S6K1-WT | Descriptor: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... | Authors: | Wang, J, Zhong, C, Ding, J. | Deposit date: | 2013-06-07 | Release date: | 2013-07-24 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L45
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![BU of 4l45 by Molmil](/molmil-images/mine/4l45) | Crystal structures of human p70S6K1-T389E | Descriptor: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein | Authors: | Wang, J, Zhong, C, Ding, J. | Deposit date: | 2013-06-07 | Release date: | 2013-07-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L9I
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6Z45
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![BU of 6z45 by Molmil](/molmil-images/mine/6z45) | CDK9-Cyclin-T1 complex bound by compound 24 | Descriptor: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | Authors: | Ferguson, A, Collie, G.W. | Deposit date: | 2020-05-22 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.37 Å) | Cite: | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
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6Z4X
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![BU of 6z4x by Molmil](/molmil-images/mine/6z4x) | Structure of the CAK complex form Chaetomium thermophilum bound to ATP-gamma-S | Descriptor: | CHLORIDE ION, CYCLIN domain-containing protein, MAGNESIUM ION, ... | Authors: | Peissert, S, Kuper, J, Kisker, C. | Deposit date: | 2020-05-26 | Release date: | 2020-12-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural basis for CDK7 activation by MAT1 and Cyclin H. Proc.Natl.Acad.Sci.USA, 117, 2020
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4JLC
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![BU of 4jlc by Molmil](/molmil-images/mine/4jlc) | Crystal structure of mouse TBK1 bound to SU6668 | Descriptor: | 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, Serine/threonine-protein kinase TBK1 | Authors: | Li, P. | Deposit date: | 2013-03-12 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. Structure, 21, 2013
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4L43
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![BU of 4l43 by Molmil](/molmil-images/mine/4l43) | Crystal structures of human p70S6K1-T389A (form I) | Descriptor: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein | Authors: | Wang, J, Zhong, C, Ding, J. | Deposit date: | 2013-06-07 | Release date: | 2013-07-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L67
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![BU of 4l67 by Molmil](/molmil-images/mine/4l67) | Crystal Structure of Catalytic Domain of PAK4 | Descriptor: | Serine/threonine-protein kinase PAK 4 | Authors: | Wang, W, Song, J. | Deposit date: | 2013-06-12 | Release date: | 2013-08-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different for that of PAK1 Biochem.Biophys.Res.Commun., 438, 2013
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4LGD
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![BU of 4lgd by Molmil](/molmil-images/mine/4lgd) | Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ras association domain family member 5, ... | Authors: | Luo, X, Ni, L, Tomchick, D.R. | Deposit date: | 2013-06-27 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5. Structure, 21, 2013
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4KRC
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![BU of 4krc by Molmil](/molmil-images/mine/4krc) | Crystal Structure of Pho85-Pcl10-ATP-gamma-S Complex | Descriptor: | Cyclin-dependent protein kinase PHO85, MAGNESIUM ION, PHO85 cyclin-10, ... | Authors: | Quiocho, F.A, Zheng, F. | Deposit date: | 2013-05-16 | Release date: | 2013-09-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.597 Å) | Cite: | New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition. J.Biol.Chem., 288, 2013
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4IWP
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![BU of 4iwp by Molmil](/molmil-images/mine/4iwp) | Crystal structure and mechanism of activation of TBK1 | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | Authors: | Panne, D, Larabi, A. | Deposit date: | 2013-01-24 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.065 Å) | Cite: | Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3, 2013
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4IW0
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![BU of 4iw0 by Molmil](/molmil-images/mine/4iw0) | Crystal structure and mechanism of activation of TBK1 | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | Authors: | Larabi, A, Devos, J.M, Ng, S.-L, Nanao, M.H, Round, A, Maniatis, T, Panne, D. | Deposit date: | 2013-01-23 | Release date: | 2013-03-13 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3, 2013
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4IZ5
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![BU of 4iz5 by Molmil](/molmil-images/mine/4iz5) | Structure of the complex between ERK2 phosphomimetic mutant and PEA-15 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, ... | Authors: | Mace, P.D, Robinson, H, Riedl, S.J. | Deposit date: | 2013-01-29 | Release date: | 2013-04-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
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4M84
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![BU of 4m84 by Molmil](/molmil-images/mine/4m84) | |
4MD9
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4KIK
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![BU of 4kik by Molmil](/molmil-images/mine/4kik) | Human IkB kinase beta | Descriptor: | Inhibitor of nuclear factor kappa-B kinase subunit beta, K-252A | Authors: | Liu, S, Mosyak, L. | Deposit date: | 2013-05-02 | Release date: | 2013-06-26 | Last modified: | 2013-08-28 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Crystal Structure of a Human I kappa B Kinase beta Asymmetric Dimer. J.Biol.Chem., 288, 2013
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