PDB: 934 resultsInfo pagesStatus searchChemie searchBIRD

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9F7H	UP1 in complex with Z45617795 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-(2-phenylethyl)methanesulfonamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-05-03 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
8WQ5	Crystal structure of the C-terminal RRM domain of an RBP in complex with ssDNA Descriptor: DNA (5'-D(*GP*AP*CP*GP*CP*AP*G)-3'), GLYCEROL, RNA-binding protein 45 Authors: Chen, X, Yang, Z, Chen, X, Wei, Q, Guo, S, Jiang, M, Wang, M. Deposit date: 2023-10-11 Release date: 2024-08-21 Last modified: 2024-09-18 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural basis for RNA recognition by the C-terminal RRM domain of human RBM45. J.Biol.Chem., 300, 2024
9F4M	UP1 in complex with Z1401276297 Descriptor: (5~{R})-7-pyrazin-2-yl-2-oxa-7-azaspiro[4.4]nonane, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F7F	UP1 in complex with Z1491353358 Descriptor: (3S)-1-(phenylsulfonyl)pyrrolidin-3-amine, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-05-03 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9C7A	Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, SODIUM ION, ... Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2024-06-10 Release date: 2024-10-02 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published
9C7B	Crystal structure of R150H neurodevelopmental disease-associated U2AF2 variant Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2024-06-10 Release date: 2024-10-02 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published
9GEA	Structure of UP1 S4DS6D phosphomimetic mutant Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-08-07 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structure of UP1 S4DS6D phosphomimetic mutant To Be Published
2KRR	Solution structure of the RBD1,2 domains from human nucleolin Descriptor: Nucleolin Authors: Arumugam, N, Miller, C, Maliekal, J, Bates, P.J, Trent, J.O, Lane, A.N. Deposit date: 2009-12-22 Release date: 2010-05-05 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: Solution structure of the RBD1,2 domains from human nucleolin. J.Biomol.Nmr, 47, 2010
2KH9	Solution structure of yeast Prp24-RRM2 bound to a fragment of U6 RNA Descriptor: 5'-R(*AP*GP*AP*GP*AP*U)-3', U4/U6 snRNA-associated-splicing factor PRP24 Authors: Martin-Tumasz, S.A, Butcher, S.E. Deposit date: 2009-03-27 Release date: 2010-03-09 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24. Rna, 16, 2010
2HGM	NMR structure of the second qRRM domain of human hnRNP F Descriptor: Heterogeneous nuclear ribonucleoprotein F Authors: Dominguez, C, Allain, F.H.-T. Deposit date: 2006-06-27 Release date: 2006-07-11 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition. Nucleic Acids Res., 34, 2006
2KVI	Structure of Nab3 RRM Descriptor: Nuclear polyadenylated RNA-binding protein 3 Authors: Pergoli, R, Kubicek, K, Hobor, F, Pasulka, J, Stefl, R. Deposit date: 2010-03-15 Release date: 2010-11-17 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structure and RNA-binding study of RNA-recognition motif of Nab3 J.Biol.Chem., 2010
2KXH	Solution structure of the first two RRM domains of FIR in the complex with FBP Nbox peptide Descriptor: Poly(U)-binding-splicing factor PUF60, peptide of Far upstream element-binding protein 1 Authors: Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G. Deposit date: 2010-05-05 Release date: 2010-08-18 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Molecular basis of FIR-mediated c-myc transcriptional control. Nat.Struct.Mol.Biol., 17, 2010
2KXF	Solution structure of the first two RRM domains of FBP-interacting repressor (FIR) Descriptor: Poly(U)-binding-splicing factor PUF60 Authors: Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G. Deposit date: 2010-05-04 Release date: 2010-08-18 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Molecular basis of FIR-mediated c-myc transcriptional control. Nat.Struct.Mol.Biol., 17, 2010
2J76	Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B Descriptor: EUKARYOTIC TRANSLATION INITIATION FACTOR 4B Authors: Fleming, K, Ghuman, J, Yuan, X.M, Simpson, P, Szendroi, A, Matthews, S, Curry, S. Deposit date: 2006-10-06 Release date: 2008-10-28 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution Structure and RNA Interactions of the RNA Recognition Motif from Eukaryotic Translation Initiation Factor 4B. Biochemistry, 42, 2003
2JX2	Solution conformation of RNA-bound NELF-E RRM Descriptor: Negative elongation factor E Authors: Jampani, N, Schweimer, K, Wenzel, S, Woehrl, B.M, Roesch, P. Deposit date: 2007-11-02 Release date: 2008-04-08 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: NELF-E RRM Undergoes Major Structural Changes in Flexible Protein Regions on Target RNA Binding Biochemistry, 47, 2008
2KXN	NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA Descriptor: 5'-R(*AP*AP*GP*AP*AP*C)-3', Transformer-2 protein homolog beta Authors: Clery, A, Jayne, S, Benderska, N, Dominguez, C, Stamm, S, Allain, F.H.-T. Deposit date: 2010-05-10 Release date: 2011-03-16 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-beta1 Nat.Struct.Mol.Biol., 18, 2011
2KM8	Interdomain RRM packing contributes to RNA recognition in the rna15, hrp1, anchor RNA 3' processing ternary complex Descriptor: 5'-R(P*UP*AP*UP*AP*UP*AP*UP*AP*AP*UP*AP*AP*U)-3', Nuclear polyadenylated RNA-binding protein 4, mRNA 3'-end-processing protein RNA15 Authors: Leeper, T.C, Varani, G. Deposit date: 2009-07-24 Release date: 2010-07-28 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: Novel Protein-Protein Contacts Facilitate mRNA 3'-Processing Signal Recognition by Rna15 and Hrp1. J.Mol.Biol., 401, 2010
2I38	Solution structure of the RRM of SRp20 Descriptor: Fusion protein consists of immunoglobulin G-Binding Protein G and Splicing factor, arginine/serine-rich 3 Authors: Hargous, Y.F, Allain, F.H.T. Deposit date: 2006-08-17 Release date: 2006-12-12 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. Embo J., 25, 2006
2LEB	Solution structure of human SRSF2 (SC35) RRM in complex with 5'-UCCAGU-3' Descriptor: RNA (5'-R(*UP*CP*CP*AP*GP*U)-3'), Serine/arginine-rich splicing factor 2 Authors: Daubner, G.M, Clery, A, Jayne, S, Stevenin, J, Allain, F.H.-T. Deposit date: 2011-06-15 Release date: 2011-11-23 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well. Embo J., 31, 2012
2LEA	Solution structure of human SRSF2 (SC35) RRM Descriptor: Serine/arginine-rich splicing factor 2 Authors: Daubner, G.M, Clery, A, Jayne, S, Stevenin, J, Allain, F.H.-T. Deposit date: 2011-06-15 Release date: 2011-11-23 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well. Embo J., 31, 2012
2HVZ	Solution structure of the RRM domain of SR rich factor 9G8 Descriptor: Splicing factor, arginine/serine-rich 7 Authors: Tintaru, A.M, Hautbergue, G.M, Golovanov, A.P, Lian, L.Y, Wilson, S.A. Deposit date: 2006-07-31 Release date: 2006-11-21 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. Embo J., 25, 2006
2HZC	Crystal structure of the N-terminal RRM of the U2AF large subunit Descriptor: HEXAETHYLENE GLYCOL, Splicing factor U2AF 65 kDa subunit, ZINC ION Authors: Thickman, K.R, Sickmier, E.A, Kielkopf, C.L. Deposit date: 2006-08-08 Release date: 2006-08-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF(65) RNA Recognition Motif. J.Mol.Biol., 366, 2007
2L41	Nab3 RRM - UCUU complex Descriptor: RNA (5'-R(P*UP*CP*UP*U)-3'), RRM domain from Nuclear polyadenylated RNA-binding protein 3 Authors: Stefl, R, Pergoli, R, Hobor, F, Kubicek, K, Zimmermann, M, Pasulka, J, Hofr, C. Deposit date: 2010-09-28 Release date: 2010-11-17 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (NAB) 3 protein J.Biol.Chem., 286, 2011
2K3K	Solution structure of Drosophila melanogaster SNF RBD1 Descriptor: U1 small nuclear ribonucleoprotein A Authors: Liu, C, Cui, G, Hu, J, Jin, C, Xia, B. Deposit date: 2008-05-12 Release date: 2008-06-03 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structural and Functional Studies of RNA Splicing Factor Sans-Fille by Multidimentional NMR Spectroscopy To be Published
2LKZ	Solution structure of the second RRM domain of RBM5 Descriptor: RNA-binding protein 5 Authors: Song, Z, Wu, P, Zhang, J, Wu, J, Shi, Y. Deposit date: 2011-10-23 Release date: 2012-08-08 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets Biochemistry, 2012

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