9C7A
Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant
Summary for 9C7A
Entry DOI | 10.2210/pdb9c7a/pdb |
Descriptor | Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ... (5 entities in total) |
Functional Keywords | protein-rna complex, rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna complex, rna binding protein-splicing complex, rna binding protein, rna binding protein-rna-dna complex, rna binding protein/rna/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 24853.72 |
Authors | |
Primary citation | Maji, D.,Jenkins, J.L.,Boutz, P.L.,Kielkopf, C.L. Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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